Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Julie Di Paolo"'
Autor:
Emma Rousseau, Roy Bannister, Kevin S. Currie, Jiyun Kim, Astrid S. Clarke, Kelly Wang, Julie Di Paolo, Franziska Matzkies, Bernard P. Murray
Publikováno v:
Thrombosis Research. 170:109-118
Introduction Spleen tyrosine kinase (SYK) mediates signal transduction in multiple hematopoietic cells, including platelets. SYK signals downstream of immunoreceptors and SYK inhibition may ameliorate disease pathology in multiple autoimmune disorder
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c447b0f31135a56402781f947c1baad9
https://doi.org/10.1016/j.thromres.2018.08.012
https://doi.org/10.1016/j.thromres.2018.08.012
Autor:
Eric B. Lansdon, Helen Yu, Kropf Jeffrey E, Peter A. Blomgren, Jennifer R. Lo, Guoju Geng, Kevin S. Currie, Aaron C. Schmitt, Jayaraman Chandrasekhar, Chris Pohlmeyer, Scott A. Mitchell, Seung H. Lee, Wanchi Fung, Sarah Wise, Jin-Ming Xiong, Zhongdong Zhao, Randall Mark Jones, Kimberly Suekawa-Pirrone, Julie Di Paolo, Bernard P. Murray, Carmen Ip, Jianjun Xu
Publikováno v:
ACS Med Chem Lett
[Image: see text] Spleen tyrosine kinase (SYK) is a critical regulator of signaling in a variety of immune cell types such as B-cells, monocytes, and macrophages. Accordingly, there have been numerous efforts to identify compounds that selectively in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83a219ff1dd97e346313a9eebe517807
https://pubmed.ncbi.nlm.nih.gov/32292557
https://pubmed.ncbi.nlm.nih.gov/32292557
Publikováno v:
Poster Presentations.
Background Inhibition of the Janus kinase-signal transducers and activators of transcription (JAK-STAT) pathway has demonstrated efficacy in immune-mediated diseases and has been identified as a therapeutic target for the treatment of rheumatoid arth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44bff10c4b5b0e72e8c57748a1125296
https://doi.org/10.1136/annrheumdis-2019-eular.3361
https://doi.org/10.1136/annrheumdis-2019-eular.3361
Publikováno v:
Poster Presentations.
Background: Despite improved therapy, rheumatoid arthritis (RA) remains an area of unmet medical need. Current therapies have improved disease control by targeting inflammatory pathways. However, treatments rarely induce remission, highlighting the n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8974affc8bad3c7734c66413d1dbef9c
https://doi.org/10.1136/annrheumdis-2019-eular.2145
https://doi.org/10.1136/annrheumdis-2019-eular.2145
Autor:
Jiyun Kim, Alan Kivitz, Sean Hsueh, Lin Liu, John S. Sundy, Franziska Matzkies, Neelufar Mozaffarian, Daksha Mehta, Afsaneh Mozaffarian, Wendy Jiang, Mark C. Genovese, Julie Di Paolo, Rebecca Kunder
Publikováno v:
Poster Presentations.
Background Spleen tyrosine kinase (SYK) mediates immunoreceptor signaling and is essential in activation of cells including B lymphocytes, monocytes, macrophages, dendritic cells, and osteoclasts. SYK may play an important role in the initiation and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de58232fd8f15135a53da64fe76f6948
https://doi.org/10.1136/annrheumdis-2019-eular.2144
https://doi.org/10.1136/annrheumdis-2019-eular.2144
Autor:
James J. Crawford, Joseph W. Lubach, Peter Blomgren, Pat Maciejewski, Steve Gallion, Jen Macaluso, Julie Di Paolo, Donna Dambach, Adam R. Johnson, Christine Yu, Xiaojing Wang, James Barbosa, Jin-Ming Xiong, Karin Reif, Zhongdong Zhao, Harvey Wong, Aaron C. Schmitt, Kevin S. Currie, Wendy B. Young, Kropf Jeffrey E, Scott A. Mitchell, Heleen Scheerens, Seung H. Lee, Charles Eigenbrot, Meire Bremer, Daniel F. Ortwine, Jianjun Xu, Lichuan Liu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:575-579
BTK inhibitor GDC-0834 (1) was found to be rapidly metabolized in human studies, resulting in a suspension of clinical trials. The primary route of metabolism was through cleavage of the acyclic amide bond connecting the terminal tetrahydrobenzothiop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cf6fb1bae7e3532455b3d6860ca9fdb
https://doi.org/10.1016/j.bmcl.2015.11.076
https://doi.org/10.1016/j.bmcl.2015.11.076
Publikováno v:
Gastroenterology. 158:S-1212
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47997d0a3a9304188d2c2aa72f78df40
https://doi.org/10.1016/s0016-5085(20)33690-8
https://doi.org/10.1016/s0016-5085(20)33690-8
Autor:
Aaron C. Schmitt, Donna Dambach, Jen Macaluso, Kevin S. Currie, Xiaojing Wang, James Barbosa, Sarah G. Hymowitz, Kropf Jeffrey E, Steve Gallion, Peter Blomgren, Lichuan Liu, Scott A. Mitchell, Julie Di Paolo, Jin-Ming Xiong, Joseph W. Lubach, Pat Maciejewski, C. Gregory Sowell, Heleen Scheerens, Seung H. Lee, Karin Reif, Zhongdong Zhao, Wendy B. Young, Jianjun Xu, Harvey Wong, Brigitte Maurer, Daniel F. Ortwine, James J. Crawford, Meire Bremer
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25(6):1333-1337
SAR studies focused on improving the pharmacokinetic (PK) properties of the previously reported potent and selective Btk inhibitor CGI-1746 (1) resulted in the clinical candidate GDC-0834 (2), which retained the potency and selectivity of CGI-1746, b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c496f050f083aefc72670970299af579
Autor:
Yingjie Han, Julie Di Paolo, Frank Y. Ma, John Kanellis, Greg H. Tesch, Sharmila Ramessur Chandran, William R. Mulley, David J. Nikolic-Paterson
Publikováno v:
Transplantation. 101(8)
Background Organ transplantation into sensitized patients with preexisting donor-specific antibodies (DSA) is very challenging. Spleen tyrosine kinase (Syk) promotes leukocyte recruitment and activation via signaling through various cell surface rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43688a070d8b830b6b6f9c2e5c639f43
https://pubmed.ncbi.nlm.nih.gov/28594748
https://pubmed.ncbi.nlm.nih.gov/28594748
Autor:
J. Andrew Whitney, Kevin S. Currie, Deborah Maclin, James Barbosa, Kropf Jeffrey E, Ann Marie Rossi, Eric B. Lansdon, Jennifer Macaluso, Scott A. Mitchell, Hong Rong, Tony Lee, Jianjun Xu, Steve Gallion, Patricia Maciejewski, Julie Di Paolo, Peter A. Blomgren, Zhongdong Zhao
Publikováno v:
Journal of Medicinal Chemistry. 57:3856-3873
Spleen tyrosine kinase (Syk) is an attractive drug target in autoimmune, inflammatory, and oncology disease indications. The most advanced Syk inhibitor, R406, 1 (or its prodrug form fostamatinib, 2), has shown efficacy in multiple therapeutic indica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2b4e26bd97c65595d3ff3afda0fbb23
https://doi.org/10.1021/jm500228a
https://doi.org/10.1021/jm500228a