Výsledky vyhledávání - "Julie Desbarats"

Akademický článek

Wengen, the sole tumour necrosis factor receptor in Drosophila, collaborates with moesin to control photoreceptor axon targeting during development.

Autor: Wenjing Ruan, Nicolas Unsain, Julie Desbarats, Edward A Fon, Philip A Barker

Publikováno v: PLoS ONE, Vol 8, Iss 3, p e60091 (2013)

Photoreceptor neurons (R cells) in the Drosophila eye define a map of visual space by connecting to targets in distinct layers of the optic lobe, with R1-6 cells connecting to the lamina (the first optic ganglion) and R7 and R8 cells connecting to th

Externí odkaz: https://doaj.org/article/ff5dd81bc1ee45e293d2d0f91a730859

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Pyridoxal 5'-phosphate to mitigate immune dysregulation and coagulopathy in COVID-19

Autor: Julie Desbarats

Although most cases of COVID-19 are paucisymptomatic, severe disease is characterized by immune dysregulation, with a decreased type I interferon response, increased inflammatory indicators, surging IL-6, IL-10 and TNFα suggestive of cytokine storm,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2189077acd8713dfbb089efe92555894
https://doi.org/10.20944/preprints202005.0144.v1

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Fas expression promotes proteasomal activity in toxin-induced parkinsonism

Autor: Rosmarie Siegrist-Johnstone, Julie Desbarats, Anne M. Landau

Publikováno v: Landau, A M, Siegrist-Johnstone, R & Desbarats, J 2011, ' Fas expression promotes proteasomal activity in toxin-induced parkinsonism ', Acta Neuropsychiatrica . https://doi.org/10.1111/j.1601-5215.2011.00615.x

Objective: Fas (CD95), commonly categorised as a death receptor due to its well-defined role in apoptosis, can paradoxically also promote neuroprotection. We have previously found that defects in Fas signalling render mice highly susceptible to neura

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf932ada7b5c682c6eaab506f99d9d3e
https://doi.org/10.1111/j.1601-5215.2011.00615.x

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Fas ligand acts as a counter-receptor in Schwann cells and induces the secretion of bioactive nerve growth factor

Autor: Guillermina Almazan, Manuelle Mimouni-Rongy, Julie Desbarats, John H. White, David E. Weinstein

Publikováno v: Journal of Neuroimmunology. 230:17-25

Fas ligand (FasL) is best known for its role in apoptosis. Membrane-bound FasL can signal in FasL-bearing cells, a process known as reverse signalling. The biological and functional consequences of FasL reverse signalling in Schwann cells were studie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca6a0110c729bc7042dff0a9a996a633
https://doi.org/10.1016/j.jneuroim.2010.08.010

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FasL Expression in Activated T Lymphocytes Involves HuR-mediated Stabilization

Autor: Sergio Di Marco, Julie Desbarats, Imed-Eddine Gallouzi, Virginie Dormoy-Raclet, Gillian L. Drury

Publikováno v: Journal of Biological Chemistry. 285:31130-31138

A prolonged activation of the immune system is one of the main causes of hyperproliferation of lymphocytes leading to defects in immune tolerance and autoimmune diseases. Fas ligand (FasL), a member of the TNF superfamily, plays a crucial role in con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72a57d82568d6d706294fdd8c183d529
https://doi.org/10.1074/jbc.m110.137919

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Dendritic Cell Differentiation Signals Induce Anti-Inflammatory Properties in Human Adult Microglia

Autor: André Olivier, Nathalie Arbour, Jeffery A. Hall, Jack P. Antel, Caroline Lambert, Amit Bar-Or, Julie Desbarats

Publikováno v: The Journal of Immunology. 181:8288-8297

Microglia are resident cells of the CNS that belong to the myeloid cell lineage. In experimental models of neuroinflammation, they have limited capacity to function as APCs when compared with dendritic cells (DCs). Human peripheral blood monocytes ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3ce6d981d6b0b569cb03154ba8f2590
https://doi.org/10.4049/jimmunol.181.12.8288

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The adaptor protein Grb2 regulates cell surface Fas ligand in Schwann cells

Autor: Peter B. Thornhill, Julie Desbarats, William L. Stanford, Jason B. Cohn

Publikováno v: Biochemical and Biophysical Research Communications. 376:341-346

Fas Ligand (FasL, CD178) is a cytokine that may be secreted or expressed as a transmembrane ligand at the cell surface, and induces apoptosis by binding to the "death receptor" Fas (CD95). Here, we show that Grb2, an SH3 domain-containing adaptor pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70db681fec750031bcb2a739e031f2e4
https://doi.org/10.1016/j.bbrc.2008.08.164

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A proteomic screen reveals novel Fas ligand interacting proteins within nervous system Schwann cells

Autor: Gillian L. Drury, Julie Desbarats, William L. Stanford, Alan Bernstein, Peter B. Thornhill, Jason B. Cohn

Publikováno v: FEBS Letters. 581:4455-4462

Fas ligand (FasL) binds Fas (CD95) to induce apoptosis or activate other signaling pathways. In addition, FasL transduces bidirectional or ‘reverse signals’. The intracellular domain of FasL contains consensus sequences for phosphorylation and an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b3f30c89c4680ee405b2d971b1b541
https://doi.org/10.1016/j.febslet.2007.08.025

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Convergence of vitamin D and retinoic acid signalling at a common hormone response element

Autor: Mario Ramirez-Calderon, Luz E. Tavera-Mendoza, Rui Zhang, Benjamin Lallemant, Véronique Bourdeau, Sylvie Mader, Julie Desbarats, John H. White, Yoshihiko Nagai, Tian-Tian Wang

Publikováno v: EMBO reports. 7:180-185

Although 1,25-dihydroxyvitamin D3 (1,25D3) and retinoic acid (RA) have distinct developmental and physiological roles, both regulate the cell cycle. We provide molecular and genomic evidence that their cognate nuclear receptors regulate common genes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fc72563e72ad9b7b53c5ea1696caf09
https://doi.org/10.1038/sj.embor.7400594

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Defective Fas expression exacerbates neurotoxicity in a model of Parkinson's disease

Autor: Rosmarie Siegrist-Johnstone, Vladimir V. Rymar, Yoon Kow Young, Alain Dagher, Edouard Kouassi, Michelle-Lee Jones, Abbas F. Sadikot, Anne M. Landau, Kelvin C. Luk, Julie Desbarats

Publikováno v: Landau, A, Luk, K C, Jones, M-L, Siegrist-Johnstone, R, Young, Y K, Kouassi, E, Rymar, V V, Dagher, A, Sadikot, A F & Desbarats, J 2005, ' Defective Fas expression exacerbates neurotoxicity in a model of Parkinson's disease ', Journal of Experimental Medicine, vol. 202, no. 5, pp. 575-81 . https://doi.org/10.1084/jem.20050163
The Journal of Experimental Medicine

Fas (CD95), a member of the tumor necrosis factor-receptor superfamily, has been studied extensively as a death-inducing receptor in the immune system. However, Fas is also widely expressed in a number of other tissues, including in neurons. Here, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e90a00ad19101f991d9e63bd0e276554
https://doi.org/10.1084/jem.20050163

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