Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Julie DeWever"'
Publikováno v:
The Journal of Immunology. 178:1505-1511
Tumors may evade immune responses at multiple levels, including through a defect in the lymphocyte-vessel wall interactions. The angiogenic nature of endothelial cells (EC) lining tumor blood vessels may account for such anergy. In this study, we exa
Autor:
Philippe Martinive, Olivier Feron, Bernard Gallez, Bénédicte F. Jordan, Réginald Ansiaux, Nathalie Crokart, Christine Baudelet, Vincent Grégoire, Julie DeWever
Publikováno v:
Cancer Research, Vol. 66, no. 19, p. 9698-9704 (2006)
Emerging preclinical studies support the concept of a transient “normalization” of tumor vasculature during the early stage of antiangiogenic treatment, with possible beneficial effects on associated radiotherapy or chemotherapy. One key issue in
Autor:
Suzan Batova, Olivier Feron, Chantal Dessy, Jean-Luc Balligand, Theophile Godfraind, Julie DeWever
Publikováno v:
Cardiovascular Research. 71:478-485
OBJECTIVES: Amlodipine is a calcium channel blocker (CCB) known to stimulate nitric oxide production from endothelial cells. Whether this ancillary property can be related to the capacity of amlodipine to concentrate and alter the structure of choles
Autor:
Nathalie Crokart, Julie DeWever, Greg O. Cron, Réginald Ansiaux, Bernard Gallez, Olivier Feron, Christine Baudelet
Publikováno v:
NMR in Biomedicine. 19:69-76
Acute hypoxia (transient cycles of hypoxia-reoxygenation) is known to occur in solid tumors and is generally believed to be caused by tumor blood flow instabilities. It was recently demonstrated that T2*-weighted (T2*w) gradient echo (GRE) MRI is a p
Autor:
Olivier Feron, Pierre Sonveaux, Michel Pelat, Philippe Ghisdal, Julie DeWever, Chantal Dessy, Jean-Luc Balligand, Philippe Martinive, Vincent Grégoire, Zuzana Batova, Géraldine Daneau
Publikováno v:
Circulation Research. 95:154-161
Nitric oxide (NO) is a powerful angiogenic mediator acting downstream of vascular endothelial growth factor (VEGF). Both the endothelial NO synthase (eNOS) and the VEGFR-2 receptor colocalize in caveolae. Because the structural protein of these signa
Autor:
Olivier Feron, Bernard Gallez, Vincent Grégoire, Bénédicte F. Jordan, Réginald Ansiaux, Julie DeWever
Publikováno v:
Radiation research. 172(5)
We investigated the early effects of vandetanib (ZACTIMA; ZD6474), an inhibitor of VEGFR-dependent angiogenesis, on tumor oxygenation and on the possible consequences of combining vandetanib with radiotherapy. Tumor oxygenation, perfusion, cellular c
Autor:
Bernard Gallez, Jean-François Baurain, Olivier Feron, Mustapha Dinguizli, Julie DeWever, Emilia Sabina Vanea, Nicolas Charlier
Publikováno v:
NMR in biomedicine. 21(3)
The incidence of malignant melanoma is increasing at an alarming rate. As the clinical outcome of the disease strongly depends on the localization of the lesion, early detection at the initial stages of development is critical. Here, we suggest spati
Autor:
Caroline Bouzin, Olivier Feron, Christine Baudelet, Françoise Frérart, Chantal Dessy, Pierre Sonveaux, Réginald Ansiaux, Bernard Gallez, Julie DeWever
Publikováno v:
The American journal of pathology. 171(5)
In the normal microvasculature, caveolin-1, the structural protein of caveolae, modulates transcytosis and paracellular permeability. Here, we used caveolin-1-deficient mice (Cav(-/-)) to track the potential active roles of caveolin-1 down-modulation
Autor:
Caroline Bouzin, Françoise Frérart, Pierre Sonveaux, Bernard Gallez, Agnès Brouet, Julie DeWever, Olivier Feron, Bénédicte F. Jordan
Publikováno v:
International journal of radiation oncology, biology, physics. 67(4)
PURPOSE: To determine whether radiation-induced increases in nitric oxide (NO) production can influence tumor blood flow and improve delivery of Akt-targeting therapeutic DNA lipocomplexes to the tumor. METHODS AND MATERIALS: The contribution of NO t
Autor:
Agnès Brouet, Pierre Sonveaux, Xavier Havaux, Philippe Martinive, Julie DeWever, Olivier Feron, Caroline Bouzin
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 19(6)
In tumors, caveolin-1, the structural protein of caveolae, constitutes a key switch through its function as a tumor suppressor and a promoter of metastases. In endothelial cells (EC), caveolin is also known to directly interact with the endothelial n