Zobrazeno 1 - 10
of 255
pro vyhledávání: '"Julie D. Forman-Kay"'
Autor:
Alyssa Pastic, Michael L. Nosella, Annahat Kochhar, Zi Hao Liu, Julie D. Forman-Kay, Damien D’Amours
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114419- (2024)
Summary: The compaction of chromatin into mitotic chromosomes is essential for faithful transmission of the genome during cell division. In eukaryotes, chromosome morphogenesis is regulated by the condensin complex, though the exact mechanism used to
Externí odkaz:
https://doaj.org/article/dbfc8f88d5674f159a36f7d4dc387b8c
Autor:
Yu-Xi Xiao, Seon Yong Lee, Magali Aguilera-Uribe, Reuben Samson, Aaron Au, Yukti Khanna, Zetao Liu, Ran Cheng, Kamaldeep Aulakh, Jiarun Wei, Adrian Granda Farias, Taylor Reilly, Saba Birkadze, Andrea Habsid, Kevin R. Brown, Katherine Chan, Patricia Mero, Jie Qi Huang, Maximilian Billmann, Mahfuzur Rahman, Chad Myers, Brenda J. Andrews, Ji-Young Youn, Christopher M. Yip, Daniela Rotin, W. Brent Derry, Julie D. Forman-Kay, Alan M. Moses, Iva Pritišanac, Anne-Claude Gingras, Jason Moffat
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114417- (2024)
Summary: The ability to sense and respond to osmotic fluctuations is critical for the maintenance of cellular integrity. We used gene co-essentiality analysis to identify an unappreciated relationship between TSC22D2, WNK1, and NRBP1 in regulating ce
Externí odkaz:
https://doaj.org/article/6cfa9d4fad5f4dfe962cefa4d0b2f79f
Autor:
Livia O. Loureiro, Jennifer L. Howe, Miriam S. Reuter, Alana Iaboni, Kristina Calli, Delnaz Roshandel, Iva Pritišanac, Alan Moses, Julie D. Forman-Kay, Brett Trost, Mehdi Zarrei, Olivia Rennie, Lynette Y. S. Lau, Christian R. Marshall, Siddharth Srivastava, Brianna Godlewski, Elizabeth D. Buttermore, Mustafa Sahin, Dean Hartley, Thomas Frazier, Jacob Vorstman, Stelios Georgiades, Suzanne M. E. Lewis, Peter Szatmari, Clarrisa A. (Lisa) Bradley, Anne-Claude Tabet, Marjolaine Willems, Serge Lumbroso, Amélie Piton, James Lespinasse, Richard Delorme, Thomas Bourgeron, Evdokia Anagnostou, Stephen W. Scherer
Publikováno v:
npj Genomic Medicine, Vol 6, Iss 1, Pp 1-12 (2021)
Abstract Autism Spectrum Disorder (ASD) is genetically complex with ~100 copy number variants and genes involved. To try to establish more definitive genotype and phenotype correlations in ASD, we searched genome sequence data, and the literature, fo
Externí odkaz:
https://doaj.org/article/54f8fe923ab549de9877b0baef9d1c16
Autor:
Jennifer E. Dawson, Alaji Bah, Zhenfu Zhang, Robert M. Vernon, Hong Lin, P. Andrew Chong, Manasvi Vanama, Nahum Sonenberg, Claudiu C. Gradinaru, Julie D. Forman-Kay
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Phosphorylation of eIF4E binding proteins (4E-BPs) controls their folding and regulates cap-dependent translation. Here, the authors show that phosphorylation of the C-terminal disordered region stabilizes the non-cooperatively folded 4E-BP domain to
Externí odkaz:
https://doaj.org/article/57e3644d3e9b45b39d26e1a240848dcf
Publikováno v:
Biomolecules, Vol 12, Iss 8, p 1131 (2022)
Protein phase separation is increasingly understood to be an important mechanism of biological organization and biomaterial formation. Intrinsically disordered protein regions (IDRs) are often significant drivers of protein phase separation. A number
Externí odkaz:
https://doaj.org/article/2a824a7e044a4604a225289120d2eca6
Autor:
Meili Liu, Akshaya K. Das, James Lincoff, Sukanya Sasmal, Sara Y. Cheng, Robert M. Vernon, Julie D. Forman-Kay, Teresa Head-Gordon
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 7, p 3420 (2021)
Many pairwise additive force fields are in active use for intrinsically disordered proteins (IDPs) and regions (IDRs), some of which modify energetic terms to improve the description of IDPs/IDRs but are largely in disagreement with solution experime
Externí odkaz:
https://doaj.org/article/ee596aef2fec4f0c97a2f915f5b4c213
Autor:
David P. Scanlon, Alaji Bah, Mickaël Krzeminski, Wenbo Zhang, Heather L. Leduc-Pessah, Yi Na Dong, Julie D. Forman-Kay, Michael W. Salter
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
N-methyl D-aspartate receptor (NMDAR) activity is modulated by Src tyrosine kinase via the mitochondrial protein NADH dehydrogenase subunit 2 (ND2). Here the authors show that ND2 interacts with the transmembrane region of NMDAR GluN1 subunit, a proc
Externí odkaz:
https://doaj.org/article/50c00c45052a4a68a4e123d4c54090df
Autor:
Anatoly Malevanets, P. Andrew Chong, D. Flemming Hansen, Paul Rizk, Yulong Sun, Hong Lin, Ranjith Muhandiram, Avi Chakrabartty, Lewis E. Kay, Julie D. Forman-Kay, Shoshana J. Wodak
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Misofolding of mammalian prion proteins (PrP) is believed to be the cause of a group of rare and fatal neurodegenerative diseases. Despite intense scrutiny however, the mechanism of the misfolding reaction remains unclear. We perform nuclear
Externí odkaz:
https://doaj.org/article/2cc9aa29f07a4e49a4b2965ad45484b5
Autor:
Saumel Ahmadi, Zoltan Bozoky, Michelle Di Paola, Sunny Xia, Canhui Li, Amy P. Wong, Leigh Wellhauser, Steven V. Molinski, Wan Ip, Hong Ouyang, Julie Avolio, Julie D. Forman-Kay, Felix Ratjen, Jeremy A. Hirota, Johanna Rommens, Janet Rossant, Tanja Gonska, Theo J. Moraes, Christine E. Bear
Publikováno v:
npj Genomic Medicine, Vol 2, Iss 1, Pp 1-10 (2017)
Cystic fibrosis: toward personalized therapies A new method for evaluating drug responses in patient-derived respiratory tissue promises to help determine the best treatment for each patient with cystic fibrosis (CF). CF patients are highly susceptib
Externí odkaz:
https://doaj.org/article/7ad6ed4d84964bd982f178ae435366d1
Autor:
Veronika Csizmok, Stephen Orlicky, Jing Cheng, Jianhui Song, Alaji Bah, Neda Delgoshaie, Hong Lin, Tanja Mittag, Frank Sicheri, Hue Sun Chan, Mike Tyers, Julie D. Forman-Kay
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
The WD40 domain of the SCFCdc4ubiquitin ligase targets substrates via multiple phosphorylated degron motifs. The authors define a second degron-binding WD40 pocket that imparts a negative allosteric effect on binding to the primary pocket, and thereb
Externí odkaz:
https://doaj.org/article/3ceb544c2e084e38929cafb11be01401