Zobrazeno 1 - 10
of 253
pro vyhledávání: '"Julie D. Forman Kay"'
Publikováno v:
Entropy, Vol 21, Iss 7, p 662 (2019)
Bioinformatics and biophysical studies of intrinsically disordered proteins and regions (IDRs) note the high entropy at individual sequence positions and in conformations sampled in solution. This prevents application of the canonical sequence-struct
Externí odkaz:
https://doaj.org/article/0c33bbf4540c4c78991b08e2ddcbad8d
Autor:
Alyssa Pastic, Michael L. Nosella, Annahat Kochhar, Zi Hao Liu, Julie D. Forman-Kay, Damien D’Amours
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114419- (2024)
Summary: The compaction of chromatin into mitotic chromosomes is essential for faithful transmission of the genome during cell division. In eukaryotes, chromosome morphogenesis is regulated by the condensin complex, though the exact mechanism used to
Externí odkaz:
https://doaj.org/article/dbfc8f88d5674f159a36f7d4dc387b8c
Autor:
Yu-Xi Xiao, Seon Yong Lee, Magali Aguilera-Uribe, Reuben Samson, Aaron Au, Yukti Khanna, Zetao Liu, Ran Cheng, Kamaldeep Aulakh, Jiarun Wei, Adrian Granda Farias, Taylor Reilly, Saba Birkadze, Andrea Habsid, Kevin R. Brown, Katherine Chan, Patricia Mero, Jie Qi Huang, Maximilian Billmann, Mahfuzur Rahman, Chad Myers, Brenda J. Andrews, Ji-Young Youn, Christopher M. Yip, Daniela Rotin, W. Brent Derry, Julie D. Forman-Kay, Alan M. Moses, Iva Pritišanac, Anne-Claude Gingras, Jason Moffat
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114417- (2024)
Summary: The ability to sense and respond to osmotic fluctuations is critical for the maintenance of cellular integrity. We used gene co-essentiality analysis to identify an unappreciated relationship between TSC22D2, WNK1, and NRBP1 in regulating ce
Externí odkaz:
https://doaj.org/article/6cfa9d4fad5f4dfe962cefa4d0b2f79f
Autor:
Livia O. Loureiro, Jennifer L. Howe, Miriam S. Reuter, Alana Iaboni, Kristina Calli, Delnaz Roshandel, Iva Pritišanac, Alan Moses, Julie D. Forman-Kay, Brett Trost, Mehdi Zarrei, Olivia Rennie, Lynette Y. S. Lau, Christian R. Marshall, Siddharth Srivastava, Brianna Godlewski, Elizabeth D. Buttermore, Mustafa Sahin, Dean Hartley, Thomas Frazier, Jacob Vorstman, Stelios Georgiades, Suzanne M. E. Lewis, Peter Szatmari, Clarrisa A. (Lisa) Bradley, Anne-Claude Tabet, Marjolaine Willems, Serge Lumbroso, Amélie Piton, James Lespinasse, Richard Delorme, Thomas Bourgeron, Evdokia Anagnostou, Stephen W. Scherer
Publikováno v:
npj Genomic Medicine, Vol 6, Iss 1, Pp 1-12 (2021)
Abstract Autism Spectrum Disorder (ASD) is genetically complex with ~100 copy number variants and genes involved. To try to establish more definitive genotype and phenotype correlations in ASD, we searched genome sequence data, and the literature, fo
Externí odkaz:
https://doaj.org/article/54f8fe923ab549de9877b0baef9d1c16
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 6, p e1010238 (2022)
A major challenge to the characterization of intrinsically disordered regions (IDRs), which are widespread in the proteome, but relatively poorly understood, is the identification of molecular features that mediate functions of these regions, such as
Externí odkaz:
https://doaj.org/article/cb97a63ed41d4fd2a040177bf0b5297a
Autor:
Jennifer E. Dawson, Alaji Bah, Zhenfu Zhang, Robert M. Vernon, Hong Lin, P. Andrew Chong, Manasvi Vanama, Nahum Sonenberg, Claudiu C. Gradinaru, Julie D. Forman-Kay
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Phosphorylation of eIF4E binding proteins (4E-BPs) controls their folding and regulates cap-dependent translation. Here, the authors show that phosphorylation of the C-terminal disordered region stabilizes the non-cooperatively folded 4E-BP domain to
Externí odkaz:
https://doaj.org/article/57e3644d3e9b45b39d26e1a240848dcf
Autor:
Geraldine Seydoux, Mingjie Zhang, Julie D. Forman-Kay, Brian McStay, Kathy Fange Liu, Pilong Li
Publikováno v:
Molecular Cell. 83:1016-1021
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a1ebdad48bbdba3cf0df8dd57efdb8a
https://doi.org/10.1016/j.molcel.2023.03.014
https://doi.org/10.1016/j.molcel.2023.03.014
Autor:
Rashik Ahmed, Julie D. Forman-Kay
Publikováno v:
Essays in Biochemistry. 66:863-873
The spatial and temporal organization of interactions between proteins underlie the regulation of most cellular processes. The requirement for such interactions to be specific predisposes a view that protein–protein interactions are relatively stat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::704e25ab726545728843812ded142e14
https://doi.org/10.1042/ebc20220056
https://doi.org/10.1042/ebc20220056
Autor:
David P. Scanlon, Alaji Bah, Mickaël Krzeminski, Wenbo Zhang, Heather L. Leduc-Pessah, Yi Na Dong, Julie D. Forman-Kay, Michael W. Salter
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
N-methyl D-aspartate receptor (NMDAR) activity is modulated by Src tyrosine kinase via the mitochondrial protein NADH dehydrogenase subunit 2 (ND2). Here the authors show that ND2 interacts with the transmembrane region of NMDAR GluN1 subunit, a proc
Externí odkaz:
https://doaj.org/article/50c00c45052a4a68a4e123d4c54090df
Autor:
Anatoly Malevanets, P. Andrew Chong, D. Flemming Hansen, Paul Rizk, Yulong Sun, Hong Lin, Ranjith Muhandiram, Avi Chakrabartty, Lewis E. Kay, Julie D. Forman-Kay, Shoshana J. Wodak
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Misofolding of mammalian prion proteins (PrP) is believed to be the cause of a group of rare and fatal neurodegenerative diseases. Despite intense scrutiny however, the mechanism of the misfolding reaction remains unclear. We perform nuclear
Externí odkaz:
https://doaj.org/article/2cc9aa29f07a4e49a4b2965ad45484b5