Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Julie D, Atkin"'
Autor:
Audrey M. G. Ragagnin, Vinod Sundaramoorthy, Fabiha Farzana, Shashi Gautam, Sayanthooran Saravanabavan, Zeinab Takalloo, Prachi Mehta, Dzung Do-Ha, Sonam Parakh, Sina Shadfar, Julie Hunter, Marta Vidal, Cyril J. Jagaraj, Mariana Brocardo, Anna Konopka, Shu Yang, Stephanie L. Rayner, Kelly L. Williams, Ian P. Blair, Roger S. Chung, Albert Lee, Lezanne Ooi, Julie D. Atkin
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-20 (2023)
Abstract Amyotrophic lateral sclerosis (ALS) is a severely debilitating neurodegenerative condition that is part of the same disease spectrum as frontotemporal dementia (FTD). Mutations in the CCNF gene, encoding cyclin F, are present in both sporadi
Externí odkaz:
https://doaj.org/article/1f9777d0e41944dcbe2282cfb312d1fe
Publikováno v:
Translational Neurodegeneration, Vol 12, Iss 1, Pp 1-34 (2023)
Abstract Redox homeostasis refers to the balance between the production of reactive oxygen species (ROS) as well as reactive nitrogen species (RNS), and their elimination by antioxidants. It is linked to all important cellular activities and oxidativ
Externí odkaz:
https://doaj.org/article/7eeb52fef2d74fe6b530ebb98ff4eb0a
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Externí odkaz:
https://doaj.org/article/e81fb6ac569e40e89efc3bb1ac666617
Autor:
Anna Konopka, Julie D. Atkin
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Damage to DNA is generally considered to be a harmful process associated with aging and aging-related disorders such as neurodegenerative diseases that involve the selective death of specific groups of neurons. However, recent studies have provided e
Externí odkaz:
https://doaj.org/article/dba49bb12d32416fa180cd445259a849
Autor:
Stephanie L. Rayner, Shu Yang, Natalie E. Farrawell, Cyril J. Jagaraj, Flora Cheng, Jennilee M. Davidson, Luan Luu, Alberto G. Redondo, Alberto Rábano, Daniel Borrego-Hernández, Julie D. Atkin, Marco Morsch, Ian P. Blair, Justin J. Yerbury, Roger Chung, Albert Lee
Publikováno v:
Neurobiology of Disease, Vol 167, Iss , Pp 105673- (2022)
Background: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterised by the loss of upper and lower motor neurons in the brain and spinal cord. ALS and frontotemporal dementia (FTD) are overlapping diseases with shared p
Externí odkaz:
https://doaj.org/article/8b0375252ae3453588b0ea1234e98d29
Autor:
Anna Konopka, Julie D. Atkin
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
DNA is under constant attack from both endogenous and exogenous sources, and when damaged, specific cellular signalling pathways respond, collectively termed the “DNA damage response.” Efficient DNA repair processes are essential for cellular via
Externí odkaz:
https://doaj.org/article/0465b214c748456c95cb48a87f231346
Autor:
Anna Konopka, Donna R. Whelan, Md Shafi Jamali, Emma Perri, Hamideh Shahheydari, Reka P. Toth, Sonam Parakh, Tina Robinson, Alison Cheong, Prachi Mehta, Marta Vidal, Audrey M. G. Ragagnin, Ivan Khizhnyak, Cyril J. Jagaraj, Jasmin Galper, Natalie Grima, Anand Deva, Sina Shadfar, Garth A. Nicholson, Shu Yang, Suzanne M. Cutts, Zuzana Horejsi, Toby D. M. Bell, Adam K. Walker, Ian P. Blair, Julie D. Atkin
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-28 (2020)
Abstract Background Pathological forms of TAR DNA-binding protein 43 (TDP-43) are present in motor neurons of almost all amyotrophic lateral sclerosis (ALS) patients, and mutations in TDP-43 are also present in ALS. Loss and gain of TDP-43 functions
Externí odkaz:
https://doaj.org/article/3003b649896947f29c746f302d459637
Autor:
Julie D. Atkin, Manal A. Farg, Adam K. Walker, Catriona McLean, Doris Tomas, Malcolm K. Horne
Publikováno v:
Neurobiology of Disease, Vol 150, Iss , Pp 105232- (2021)
Externí odkaz:
https://doaj.org/article/4d52aef6de9a451ca613e4f13427285e
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2021)
The cellular redox state, or balance between cellular oxidation and reduction reactions, serves as a vital antioxidant defence system that is linked to all important cellular activities. Redox regulation is therefore a fundamental cellular process fo
Externí odkaz:
https://doaj.org/article/130faa342e4642b189c1870fb6584092
Autor:
Sonam Parakh, Sina Shadfar, Emma R. Perri, Audrey M.G. Ragagnin, Claudia V. Piattoni, Mariela B. Fogolín, Kristy C. Yuan, Hamideh Shahheydari, Emily K. Don, Collen J. Thomas, Yuning Hong, Marcelo A. Comini, Angela S. Laird, Damian M. Spencer, Julie D. Atkin
Publikováno v:
iScience, Vol 23, Iss 5, Pp - (2020)
Summary: Pathological forms of TAR DNA-binding protein 43 (TDP-43) are present in almost all cases of amyotrophic lateral sclerosis (ALS), and 20% of familial ALS cases are due to mutations in superoxide dismutase 1 (SOD1). Redox regulation is critic
Externí odkaz:
https://doaj.org/article/5d7c8645d1a843979d2e77a8fb26be55