Zobrazeno 1 - 10
of 9 789
pro vyhledávání: '"Julie D"'
Autor:
Samira Merali, David H. Salinger, Maria Palmisano, Amy J. Sehnert, Neelima Thanneer, Hyunmoon Back, Julie D. Seroogy, Daniel D. Gretler, Amit Roy, Vidya Perera
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 9, Pp 1448-1461 (2024)
Abstract Mavacamten is the first cardiac myosin inhibitor approved by the US Food and Drug Administration for the treatment of adults with symptomatic obstructive hypertrophic cardiomyopathy (HCM). The phase III EXPLORER‐HCM (NCT03470545) study use
Externí odkaz:
https://doaj.org/article/2d97afb3b2c44e46bccc7c6593bb0036
Autor:
Peter Chang, Vidya Perera, David H. Salinger, Samira Merali, Neelima Thanneer, Hyunmoon Back, Julie D. Seroogy, Daniel D. Gretler, Amy J. Sehnert, Maria Palmisano, Amit Roy
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 9, Pp 1462-1475 (2024)
Abstract Mavacamten is a selective, allosteric, reversible cardiac myosin inhibitor that has been developed for the treatment of adults with symptomatic obstructive hypertrophic cardiomyopathy (HCM). A population pharmacokinetic (PopPK) model was dev
Externí odkaz:
https://doaj.org/article/eaceb752f6ca46f980e5f1d94592e26c
Autor:
Nancy Keller, Julian Midgley, Ehtesham Khalid, Harry Lesmana, Georgie Mathew, Christine Mincham, Norbert Teig, Zubair Khan, Indu Khosla, Sam Mehr, Tulay Guran, Kathrin Buder, Hong Xu, Khalid Alhasan, Gonul Buyukyilmaz, Nicole Weaver, Julie D. Saba
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 19, Iss 1, Pp 1-17 (2024)
Abstract Background Sphingosine-1-phosphate lyase insufficiency syndrome (SPLIS) is a recently recognized inborn error of metabolism associated with steroid-resistant nephrotic syndrome as well as adrenal insufficiency and immunological, neurological
Externí odkaz:
https://doaj.org/article/001681b6efb54f18aee01a6b8c1590c9
Publikováno v:
Additive Manufacturing Letters, Vol 11, Iss , Pp 100254- (2024)
Functionally graded materials are an emergent method for designing components with programmable site-specific material properties. These materials are typically fabricated using metal additive manufacturing tools by simultaneously feeding multiple wi
Externí odkaz:
https://doaj.org/article/175c2d07f53e450987f879393ef928c6
Publikováno v:
BMJ Neurology Open, Vol 6, Iss Suppl 1 (2024)
Externí odkaz:
https://doaj.org/article/328f314aa8044521b6c4f7d529822ab6
Autor:
Yadi Tang, Mariola Majewska, Britta Leß, Ilir Mehmeti, Philipp Wollnitzke, Nina Semleit, Bodo Levkau, Julie D. Saba, Gerhild van Echten-Deckert, Ewa Gurgul-Convey
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 8, Pp 100587- (2024)
Lipotoxicity has been considered the main cause of pancreatic beta-cell failure during type 2 diabetes development. Lipid droplets (LD) are believed to regulate the beta-cell sensitivity to free fatty acids (FFA), but the underlying molecular mechani
Externí odkaz:
https://doaj.org/article/f3e16ef9cddd4886b684f4887a91e450
Publikováno v:
BMC Plant Biology, Vol 24, Iss 1, Pp 1-20 (2024)
Abstract Background Many parasitic plants of the genera Striga and Cuscuta inflict huge agricultural damage worldwide. To form and maintain a connection with a host plant, parasitic plants deploy virulence factors (VFs) that interact with host biolog
Externí odkaz:
https://doaj.org/article/f5a71adc412940499c625c5aa3da54d4
Autor:
Brian J. Andonian, Leanna M. Ross, Alyssa M. Sudnick, Johanna L. Johnson, Carl F. Pieper, Kelsey B. Belski, Julie D. Counts, Alyssa P. King, Jessica T. Wallis, William C. Bennett, Jillian C. Gillespie, Kaileigh M. Moertl, Dylan Richard, Janet L. Huebner, Margery A. Connelly, Ilene C. Siegler, William E. Kraus, Connie W. Bales, Kathryn N. Porter Starr, Kim M. Huffman
Publikováno v:
ACR Open Rheumatology, Vol 6, Iss 3, Pp 124-136 (2024)
Objective To compare a remotely supervised weight loss and exercise intervention to lifestyle counseling for effects on cardiovascular disease risk, disease activity, and patient‐reported outcomes in older patients with rheumatoid arthritis (RA) an
Externí odkaz:
https://doaj.org/article/4770f336bd3245e0ac26400c4ef39cfd
Autor:
Alyssa Pastic, Michael L. Nosella, Annahat Kochhar, Zi Hao Liu, Julie D. Forman-Kay, Damien D’Amours
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114419- (2024)
Summary: The compaction of chromatin into mitotic chromosomes is essential for faithful transmission of the genome during cell division. In eukaryotes, chromosome morphogenesis is regulated by the condensin complex, though the exact mechanism used to
Externí odkaz:
https://doaj.org/article/dbfc8f88d5674f159a36f7d4dc387b8c
Autor:
Yu-Xi Xiao, Seon Yong Lee, Magali Aguilera-Uribe, Reuben Samson, Aaron Au, Yukti Khanna, Zetao Liu, Ran Cheng, Kamaldeep Aulakh, Jiarun Wei, Adrian Granda Farias, Taylor Reilly, Saba Birkadze, Andrea Habsid, Kevin R. Brown, Katherine Chan, Patricia Mero, Jie Qi Huang, Maximilian Billmann, Mahfuzur Rahman, Chad Myers, Brenda J. Andrews, Ji-Young Youn, Christopher M. Yip, Daniela Rotin, W. Brent Derry, Julie D. Forman-Kay, Alan M. Moses, Iva Pritišanac, Anne-Claude Gingras, Jason Moffat
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114417- (2024)
Summary: The ability to sense and respond to osmotic fluctuations is critical for the maintenance of cellular integrity. We used gene co-essentiality analysis to identify an unappreciated relationship between TSC22D2, WNK1, and NRBP1 in regulating ce
Externí odkaz:
https://doaj.org/article/6cfa9d4fad5f4dfe962cefa4d0b2f79f