Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Julie Coote"'
Autor:
Henry Danahay, Angelica D. Pessotti, Julie Coote, Brooke E. Montgomery, Donghui Xia, Aaron Wilson, Haidi Yang, Zhao Wang, Luke Bevan, Chris Thomas, Stephanie Petit, Anne London, Peter LeMotte, Arno Doelemeyer, Germán L. Vélez-Reyes, Paula Bernasconi, Christy J. Fryer, Matt Edwards, Paola Capodieci, Amy Chen, Marc Hild, Aron B. Jaffe
Publikováno v:
Cell Reports, Vol 10, Iss 2, Pp 239-252 (2015)
The balance and distribution of epithelial cell types is required to maintain tissue homeostasis. A hallmark of airway diseases is epithelial remodeling, leading to increased goblet cell numbers and an overproduction of mucus. In the conducting airwa
Externí odkaz:
https://doaj.org/article/cfa1ebaef5e743b4be4aa0de575db29f
Autor:
Mesias Pedroza, Daniel J Schneider, Harry Karmouty-Quintana, Julie Coote, Stevan Shaw, Rebecca Corrigan, Jose G Molina, Joseph L Alcorn, David Galas, Richard Gelinas, Michael R Blackburn
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22667 (2011)
BackgroundChronic lung diseases are the third leading cause of death in the United States due in part to an incomplete understanding of pathways that govern the progressive tissue remodeling that occurs in these disorders. Adenosine is elevated in th
Externí odkaz:
https://doaj.org/article/55b1329ceccf4e169ad2b50505e6c82d
Autor:
Colin Chinn, Clemence Tessier, Matthew Spendiff, Ajay Lal, Marguerite Bracher, Elisabeth Rosner, Gregory Hollingworth, Paul Nicklin, Andrew James Culshaw, Matthew Thomas, Stephen Marshall, Benjamin R. Bellenie, Edward Charles Hall, Ian N. Bruce, Kuno Wuersch, Ameet Vijay Ambarkhane, Julie Coote, Gillian Wallis, James Neef, Eva Cullen, Sarah McDonald
Publikováno v:
Journal of Medicinal Chemistry. 64:12304-12321
Using a novel physiologically relevant in vitro human whole blood neutrophil shape change assay, an aminopyrazine series of selective PI3Kγ inhibitors was identified and prioritized for further optimization. Severe solubility limitations associated
Autor:
Rachel Dockry, Kimberley Holt, S Khalid, Jaclyn A. Smith, Maria G. Belvisi, Julie Coote, Angela Kelsall, Mark A. Birrell, Sara J. Bonvini, Ashley Woodcock, Michael Wortley, Eric Dubuis, Sarah A. Maher
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 193:1364-1372
Most airway diseases, including chronic obstructive pulmonary disease (COPD), are associated with excessive coughing. The extent to which this may be a consequence of increased activation of vagal afferents by pathology in the airways (e.g., inflamma
Autor:
Michael R. Blackburn, Daniel J. Schneider, David J. Galas, Richard Gelinas, Julie Coote, Harry Karmouty-Quintana, Joseph L. Alcorn, Rebecca Corrigan, Mesias Pedroza, Jose G. Molina, Stevan Shaw
Publikováno v:
PLoS ONE
PLoS ONE, Vol 6, Iss 7, p e22667 (2011)
PLoS ONE, Vol 6, Iss 7, p e22667 (2011)
BackgroundChronic lung diseases are the third leading cause of death in the United States due in part to an incomplete understanding of pathways that govern the progressive tissue remodeling that occurs in these disorders. Adenosine is elevated in th
Publikováno v:
Journal of Inflammation (London, England)
Asthma is associated with chronic airway inflammation and airway hyperreactivity (AHR). Approximately 5-10% of the asthmatic patient population suffers from severe disease which remains uncontrolled by current therapies. An acute murine model that re