A novel panel of short mononucleotide repeats linked to informative polymorphisms enabling effective high volume low cost discrimination between mismatch repair deficient and proficient tumours.

Autor: Lisa Redford, Ghanim Alhilal, Stephanie Needham, Ottie O'Brien, Julie Coaker, John Tyson, Leonardo Maldaner Amorim, Iona Middleton, Osagi Izuogu, Mark Arends, Anca Oniscu, Ángel Miguel Alonso, Sira Moreno Laguna, Richard Gallon, Harsh Sheth, Mauro Santibanez-Koref, Michael S Jackson, John Burn

Publikováno v: PLoS ONE, Vol 13, Iss 8, p e0203052 (2018)

Somatic mutations in mononucleotide repeats are commonly used to assess the mismatch repair status of tumours. Current tests focus on repeats with a length above 15bp, which tend to be somatically more unstable than shorter ones. These longer repeats

Externí odkaz: https://doaj.org/article/3e880ba13c9140f9962856f4f8dc8fd2

A novel panel of short mononucleotide repeats linked to informative polymorphisms enabling effective high volume low cost discrimination between mismatch repair deficient and proficient tumours

Autor: Richard Gallon, Osagi Izuogu, Leonardo Maldaner Amorim, Mauro Santibanez-Koref, Mark J. Arends, John Burn, Julie Coaker, Lisa Redford, Michael S. Jackson, Ottie O’Brien, Harsh Sheth, Sira Moreno Laguna, John R. Tyson, Anca Oniscu, Stephanie Needham, Ghanim Alhilal, Angel Alonso, Iona Middleton

Publikováno v: PLoS ONE, Vol 13, Iss 8, p e0203052 (2018)
Redford, L, Alhilal, G, Needham, S, O’Brien, O, Coaker, J, Tyson, J J, Maldaner Amorim, L, Middleton, I, Izuogu, O, Arends, M, Oniscu, A, Miguel Alonso, Á, Moreno Laguna, S, Gallon, R, Sheth, H, Santibanez-Koref, M, Jackson, M S & Burn, J 2018, ' A novel panel of short mononucleotide repeats linked to informative polymorphisms enabling effective high volume low cost discrimination between mismatch repair deficient and proficient tumours ', PLoS ONE . https://doi.org/10.1371/journal.pone.0203052

Somatic mutations in mononucleotide repeats are commonly used to assess the mismatch repair status of tumours. Current tests focus on repeats with a length above 15bp, which tend to be somatically more unstable than shorter ones. These longer repeats

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8080997be3d9ce533f72fb3d276a8b4
http://europepmc.org/articles/PMC6114912?pdf=render

MONONUCLEAR PHAGOCYTE POPULATIONS IN THE TRANSPLANTED HUMAN LUNG1

Autor: Julie Coaker, Lisbet Sviland, A D Gascoigne, Debra S. Milne, Paul A. Corris, Thomas Ashcroft, Archie J. Malcolm

Publikováno v: Transplantation. 66:671-673

Background. Dendritic cells (DC) are essential for the development of alloreactivity, however, little has been published regarding the distribution and phenotype of these and related mononuclear cells in human lung transplantation. Methods. Lung froz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9cafe217fa015534a9f0df5012458bb7
https://doi.org/10.1097/00007890-199809150-00024

Intestinal tumorigenesis in the Apc1638N mouse treated with aspirin and resistant starch for up to 5 months

Autor: Riccardo Fodde, Slh Williamson, Kooshkghazi, John C. Mathers, John Burn, Alex Kartheuser, Julie Coaker

Publikováno v: Scopus-Elsevier

The Apc1638N mouse model, which carries a targeted mutant allele within the adenomatous polyposis (Apc) gene and develops intestinal tumours spontaneously, predominantly in the small bowel, was used to investigate the effects of two potential chemopr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1d2b22f4e9d1821cb27688478d16668
http://www.scopus.com/inward/record.url?eid=2-s2.0-0032903863&partnerID=MN8TOARS

Resistant starch supplementation increases crypt cell proliferative state in the rectal mucosa of older healthy participants.

Autor: Malcomson, Fiona C., Willis, Naomi D., McCallum, Iain, Xie, Long, Ouwehand, Arthur C., Stowell, Julian D., Kelly, Seamus, Bradburn, D. Michael, Belshaw, Nigel J., Johnson, Ian T., Mathers, John C.

Publikováno v: British Journal of Nutrition; 8/28/2020, Vol. 124 Issue 4, p374-385, 12p