Leptospirosis: toward a better understanding of the environmental lifestyle of Leptospira

Autor: Grégoire Davignon, Julie Cagliero, Linda Guentas, Emilie Bierque, Pierre Genthon, Peggy Gunkel-Grillon, Farid Juillot, Malia Kainiu, Christine Laporte-Magoni, Mathieu Picardeau, Nazha Selmaoui-Folcher, Marie-Estelle Soupé-Gilbert, Caroline Tramier, Jessica Vilanova, Kavya Wijesuriya, Roman Thibeaux, Cyrille Goarant

Publikováno v: Frontiers in Water, Vol 5 (2023)

Leptospira is a complex bacterial genus which biodiversity has long been overlooked. In the recent years however, environmental studies have contributed to shed light on its original and current environmental habitat. Although very fragile bacteria i

Externí odkaz: https://doaj.org/article/faba0acba3af4342ae41bf26f8ee0281

Pathogenic Leptospires Limit Dendritic Cell Activation Through Avoidance of TLR4 and TRIF Signaling

Autor: Julie Cagliero, Frédérique Vernel-Pauillac, Gerald Murray, Ben Adler, Mariko Matsui, Catherine Werts

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Leptospira interrogans is a bacterial species responsible for leptospirosis, a neglected worldwide zoonosis. Mice and rats are resistant and can become asymptomatic carriers, whereas humans and some other mammals may develop severe forms of leptospir

Externí odkaz: https://doaj.org/article/7c6fb01d9eeb4efd845bcd248f32213b

Leptospirosis Pathophysiology: Into the Storm of Cytokines

Autor: Julie Cagliero, Sharon Y. A. M. Villanueva, Mariko Matsui

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)

Leptospirosis is a neglected tropical zoonosis caused by pathogenic spirochetes of the genus Leptospira. Infected reservoir animals, typically mice and rats, are asymptomatic, carry the pathogen in their renal tubules, and shed pathogenic spirochetes

Externí odkaz: https://doaj.org/article/d4173e0446c349b798fb08b78dd7bda3

Use of Golden Syrian Hamster as an Animal Model to Study Leptospirosis-Associated Immune Responses

Autor: Julie Cagliero, Karl Huet, Mariko Matsui

Publikováno v: Leptospira spp.
Nabuo Koizumi; Mathieu Picardeau. Leptospira spp., 2134, Springer Science+Business Media, pp.243-255, 2020, Methods in Molecular Biology, 978-1-0716-0458-8. ⟨10.1007/978-1-0716-0459-5_22⟩
Methods in Molecular Biology ISBN: 9781071604588

International audience; Experimental infections greatly contribute to further deepen our knowledge of infectious diseases. In the case of leptospirosis, hamsters as well as gerbils and guinea pigs have been used as animal models of acute leptospirosi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96801254a091b950344866215a4ea2f2
https://hal-riip.archives-ouvertes.fr/pasteur-02932846

Escape of TLR5 Recognition by Leptospira spp: A Rationale for Atypical Endoflagella

Autor: Mariko Matsui, Albert I. Ko, I. Gomberts Boneca, Julie Cagliero, M. Holzapfel, S. Bortolussi, Frédérique Vernel-Pauillac, Mathieu Picardeau, Laurence Fiette, Catherine Werts, Delphine Bonhomme, Dirk Werling, Elsio A. Wunder, M. Fanton d'Andon, Cyrille Goarant

Leptospira interrogans are invasive bacteria responsible for leptospirosis, a worldwide zoonosis. They possess two periplasmic endoflagella that allow their motility. L. interrogans are stealth pathogens that escape the innate immune responses of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::51d2f9aa555cc4af14829abec845ddcf
https://doi.org/10.1101/2020.05.30.121202