Pressure overload induced right ventricular remodeling is not attenuated by the anti-fibrotic agent pirfenidone

Autor: Stine Andersen, Julie Birkmose Axelsen, Steffen Ringgaard, Jens Randel Nyengaard, Signe Holm Nielsen, Federica Genovese, Morten Asser Karsdal, Janus Adler Hyldebrandt, Charlotte Brandt Sørensen, Frances S. de Man, Harm Jan Bogaard, Jens Erik Nielsen-Kudsk, Asger Andersen

Publikováno v: Pulmonary Circulation, Vol 9 (2019)

Cardiac fibrosis contributes to the development of heart failure in pulmonary hypertension. We aimed to assess the development of fibrosis and the effects of treatment with the anti-fibrotic agent pirfenidone in pressure overload induced right ventri

Externí odkaz: https://doaj.org/article/541b2e6ef80b47b688facc0c50e3c594

Sex-Dependent Changes in Right Ventricular Gene Expression in Response to Pressure Overload in a Rat Model of Pulmonary Trunk Banding

Autor: Hicham Labazi, Julie Birkmose Axelsen, Dianne Hillyard, Margaret Nilsen, Asger Andersen, Margaret R. MacLean

Publikováno v: Biomedicines, Vol 8, Iss 10, p 430 (2020)

Right ventricular hypertrophy (RVH) and subsequent failure are consequences of pulmonary arterial hypertension (PAH). While females are four times more likely to develop PAH, male patients have poorer survival even with treatment, suggesting a sex-de

Externí odkaz: https://doaj.org/article/6313fc8e6072443795423e6217b085e6

Effects of combined angiotensin II receptor antagonism and neprilysin inhibition in experimental pulmonary hypertension and right ventricular failure

Autor: Jens Erik Nielsen-Kudsk, Harm Jan Bogaard, Jens R. Nyengaard, Frances S. de Man, Julie Birkmose Axelsen, Asger Andersen, Steffen Ringgaard, Stine Andersen, Janus Adler Hyldebrandt

Publikováno v: International Journal of Cardiology, 293, 203-210. Elsevier Ireland Ltd
Andersen, S, Axelsen, J B, Ringgaard, S, Nyengaard, J R, Hyldebrandt, J A, Bogaard, H J, de Man, F S, Nielsen-Kudsk, J E & Andersen, A 2019, ' Effects of combined angiotensin II receptor antagonism and neprilysin inhibition in experimental pulmonary hypertension and right ventricular failure ', International Journal of Cardiology, vol. 293, pp. 203-210 . https://doi.org/10.1016/j.ijcard.2019.06.065

BACKGROUND: Combined angiotensin II receptor antagonism and neprilysin inhibition by LCZ696 reduces morbidity and mortality in heart failure patients and works by reducing RAAS activity and increasing cGMP levels. This study aims to evaluate the effe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2baac9c89d9ae1cace6097d74fbb45a5
http://www.scopus.com/inward/record.url?scp=85068748353&partnerID=8YFLogxK

Inhibition of monoamine oxidase A in pulmonary artery banding-induced right ventricular failure

Autor: Stine Andersen, Asger Andersen, Julie Birkmose Axelsen, Anton Vonk Noordegraaf, Ingrid Schalij, Frances Handoko de Man, Xiao-Qing Sun, Harm Jan Bogaard, Eva L Peters, Willem J. van der Laarse

Publikováno v: Journal of Molecular and Cellular Cardiology, 140, 25-25. Academic Press Inc.
Peters, E, Sun, X, Andersen, S, Axelsen, J B, Schalij, I, van der Laarse, W, Andersen, A, Bogaard, H J, Handoko-de Man, F & Noordegraaf, A V 2020, ' Inhibition of monoamine oxidase A in pulmonary artery banding-induced right ventricular failure ', Journal of Molecular and Cellular Cardiology, vol. 140, pp. 25-25 . https://doi.org/10.1016/j.yjmcc.2019.11.057

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::315794fc17adef0e75d37d229a43d494
https://research.vumc.nl/en/publications/177b9821-32ac-4999-b797-e554b62ebac2

Pressure overload induced right ventricular remodeling is not attenuated by the anti-fibrotic agent pirfenidone

Autor: Janus Adler Hyldebrandt, Jens Erik Nielsen-Kudsk, Signe Holm Nielsen, Asger Andersen, Harm Jan Bogaard, Jens R. Nyengaard, Morten A. Karsdal, Frances S. de Man, Julie Birkmose Axelsen, Stine Andersen, Steffen Ringgaard, Federica Genovese, Charlotte Brandt Sørensen

Publikováno v: Pulmonary Circulation
Andersen, S, Axelsen, J B, Ringgaard, S, Nyengaard, J R, Nielsen, S H, Genovese, F, Karsdal, M A, Hyldebrandt, J A, Sørensen, C B, deMan, F, Bogaard, H J, Nielsen-Kudsk, J E & Andersen, A 2019, ' Pressure overload induced right ventricular remodeling is not attenuated by the anti-fibrotic agent pirfenidone ', Pulmonary Circulation, vol. 9, no. 2, pp. 1-13 . https://doi.org/10.1177/2045894019848659
Andersen, S, Axelsen, J B, Ringgaard, S, Nyengaard, J R, Nielsen, S H, Genovese, F, Karsdal, M A, Hyldebrandt, J A, Sørensen, C B, de Man, F S, Bogaard, H J, Nielsen-Kudsk, J E & Andersen, A 2019, ' Pressure overload induced right ventricular remodeling is not attenuated by the anti-fibrotic agent pirfenidone ', Pulmonary Circulation, vol. 9, no. 2, pp. 1-13 . https://doi.org/10.1177/2045894019848659
Pulmonary Circulation, Vol 9 (2019)
Andersen, S, Birkmose Axelsen, J, Ringgaard, S, Randel Nyengaard, J, Holm Nielsen, S, Genovese, F, Asser Karsdal, M, Adler Hyldebrandt, J, Brandt Sørensen, C, de Man, F S, Jan Bogaard, H, Erik Nielsen-Kudsk, J & Andersen, A 2019, ' Pressure overload induced right ventricular remodeling is not attenuated by the anti-fibrotic agent pirfenidone ', Pulmonary Circulation, vol. 9, no. 2, pp. 204589401984865 . https://doi.org/10.1177/2045894019848659
Pulmonary Circulation, 9(2). University of Chicago Press

Cardiac fibrosis contributes to the development of heart failure in pulmonary hypertension. We aimed to assess the development of fibrosis and the effects of treatment with the anti-fibrotic agent pirfenidone in pressure overload induced right ventri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d8759e65d185cac56f3477d9807c9a2
http://europepmc.org/articles/PMC6540527