Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Julie Ann Spicer"'
Autor:
William A. Denny, Stephen M. F. Jamieson, Christian K. Miller, Kate H. Gartlan, Julie Ann Spicer, Jiney Jose, Karshing Chang, Matthew Bull, Hedieh Akhlaghi, Joseph A. Trapani, Jagdish K. Jaiswal, Geoff R. Hill, Patrick D. O'Connor, Anna C. Giddens
Publikováno v:
Journal of Medicinal Chemistry. 63:2229-2239
Perforin is a key effector protein in the vertebrate immune system and is secreted by cytotoxic T lymphocytes and natural killer cells to help eliminate virus-infected and transformed target cells. The ability to modulate perforin activity in vivo co
Autor:
James M. J. Dickson, Swarna A. Gamage, Julie Ann Spicer, Kit Yee Tsang, Woo-Jeong Lee, Gordon W. Rewcastle, William A. Denny, Patrick D. O'Connor, Peter R. Shepherd, Jack U. Flanagan
Publikováno v:
Chemistry – An Asian Journal. 14:1249-1261
Using a scaffold-hopping approach, imidazo[1,2-a]pyridine analogues of the ZSTK474 (benzimidazole) class of phosphatidylinositol 3-kinase (PI3K) inhibitors have been synthesized for biological evaluation. Compounds were prepared using a heteroaryl He
Autor:
Jonel Trebicka, Zeinab Abdullah, Sarah Eickhoff, Dietmar Zehn, K Manske, Meike Welz, Hedieh Akhlaghi, Percy A. Knolle, Anthony J. Demetris, Martina Anton, Joseph A. Trapani, Julie Ann Spicer, Kate H. Gartlan, Christian Kurts, Bernhard Nieswandt, Dirk Wohlleber, Wolfgang Kastenmüller
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications
Nature Communications
CD8 T cells protect the liver against viral infection, but can also cause severe liver damage that may even lead to organ failure. Given the lack of mechanistic insights and specific treatment options in patients with acute fulminant hepatitis, we de
Autor:
Joseph A. Trapani, Christian K. Miller, Jagdish K. Jaiswal, Kristiina M. Huttunen, Patrick D. O'Connor, Jiney Jose, William A. Denny, Hedieh Akhlaghi, Julie Ann Spicer, Kylie A. Browne
Publikováno v:
European Journal of Medicinal Chemistry
The structure-activity relationships for a series of arylsulphonamide-based inhibitors of the pore-forming protein perforin have been explored. Perforin is a key component of the human immune response, however inappropriate activity has also been imp
Autor:
William A. Denny, Patrick D. O'Connor, Christian K. Miller, Jagdish K. Jaiswal, Kristiina M. Huttunen, Joseph A. Trapani, Julie Ann Spicer, Kylie A. Browne, Hedieh Akhlaghi, Jiney Jose
Publikováno v:
Bioorganic & Medicinal Chemistry Letters
The pore-forming protein perforin is a key component of mammalian cell-mediated immunity and essential to the pathway that allows elimination of virus-infected and transformed cells. Perforin activity has also been implicated in certain auto-immune c
Autor:
Patricia J. Harvey, Gonzales Andrea, Shannon Leigh Black, Jeff B. Smaill, Ken Hook, Florence O. McCarthy, Stephen Fakhoury, Adrian Blaser, Haile Tecle, Freddy Rivault, Tong Zhu, Brian D. Palmer, Kevin Matthew Schlosser, Jessica Elizabeth Reed, Karen Elaine Sexton, William A. Denny, Irene W. Althaus, R. Thomas Winters, Teresa Ellis, Helen Tsenwhei Lee, Andrew M. Thompson, Erin Trachet, Alexander James Bridges, Julie Ann Spicer, Paul A. Ellis
Publikováno v:
Journal of Medicinal Chemistry. 59:8103-8124
Structure-activity relationships for inhibition of erbB1, erbB2, and erbB4 were determined for a series of quinazoline- and pyrido[3,4-d]pyrimidine-based analogues of the irreversible pan-erbB inhibitor, canertinib. Cyclic amine bearing crotonamides
Autor:
Julie Ann Spicer, William A. Denny, Kristiina M. Huttunen, Darryl S. Pickering, Mikko Gynther
Publikováno v:
Molecular Pharmaceutics. 13:2484-2491
We have recently reported that by converting a perforin inhibitor into an l-type amino acid transporter 1 (LAT1)-utilizing prodrug its cellular uptake can be greatly increased. The aim of the present study was to determine the in vivo and brain pharm
Autor:
Kristiina M. Huttunen, Elena Puris, William A. Denny, Julie Ann Spicer, Johanna Huttunen, Mikko Gynther
Publikováno v:
Journal of Medicinal Chemistry. 59:5740-5751
The l-type amino acid transporter 1 (LAT1) is a transmembrane protein carrying bulky and neutral amino acids into cells. LAT1 is overexpressed in several types of tumors, and its inhibition can result in reduced cancer cell growth. However, known LAT
Autor:
William A. Denny, Mikko Gynther, Kristiina M. Huttunen, Imke Aufderhaar, Johanna Huttunen, Julie Ann Spicer
Publikováno v:
International Journal of Pharmaceutics. 498:205-216
Perforin is a cytolytic pore-forming glycoprotein secreted by cytotoxic effector cells. It is a key component of the immune response against virus-infected and transformed cells and has been implicated in a number of human diseases. Perforin activity
Autor:
Joseph A. Trapani, Christian K. Miller, Jagdish K. Jaiswal, Kristiina M. Huttunen, Annette Ciccone, Kylie A. Browne, Julie Ann Spicer, William A. Denny
Publikováno v:
Bioorganic & Medicinal Chemistry Letters
Graphical abstract
Evolution from a furan-containing high-throughput screen (HTS) hit (1) resulted in isobenzofuran-1(3H)-one (2) as a potent inhibitor of the function of both isolated perforin protein and perforin delivered in situ by intact KH
Evolution from a furan-containing high-throughput screen (HTS) hit (1) resulted in isobenzofuran-1(3H)-one (2) as a potent inhibitor of the function of both isolated perforin protein and perforin delivered in situ by intact KH