Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Julie A. Wilder"'
Autor:
Bobby R. Scott, Steven A. Belinsky, Shuguang Leng, Yong Lin, Julie A. Wilder, Leah A. Damiani
Publikováno v:
Dose-Response, Vol 7 (2009)
Humans are continuously exposed to low-level ionizing radiation from natural sources. However, harsher radiation environments persisted during our planet's early years and mammals survived via an evolutionary gift - a system of radiation-induced natu
Externí odkaz:
https://doaj.org/article/f62376e3167546aeadc9e8a76aa27d8c
Autor:
Gensheng Wang, Christopher H Evans, Janet M Benson, Julie A Hutt, JeanClare Seagrave, Julie A Wilder, Joshua C Grieger, R Jude Samulski, Pramod S Terse
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
Interleukin-1 (IL-1) plays an important role in the pathophysiology of osteoarthritis (OA), and gene transfer of IL-1 receptor antagonist (IL-1Ra) holds promise for OA treatment. A preclinical safety and biodistribution study evaluated a self-complem
Externí odkaz:
https://doaj.org/article/6c9baaef7b4e465f9ba978ec9d3129c7
Autor:
Yohannes Tesfaigzi, Caroline A. Owen, Xiaoyun Wang, Joselyn Rojas-Quintero, Duo Zhang, Julie A. Wilder
Publikováno v:
J Immunol
Matrix metalloproteinase (MMP)–8 and –9 released by degranulating polymorphonuclear cells (PMNs) promote pericellular proteolysis by binding to PMN surfaces in a catalytically active tissue inhibitor of metalloproteinases (TIMP)-resistant forms.
Autor:
Julie A. Wilder, Mark A. Perrella, Ivan O. Rosas, Xiaoli Liu, Jacob D. McDonald, Melanie Doyle-Eisele, Nasly G Patino-Jaramillo, Konstantin Tsoyi, Sarah G. Chu, Souheil El-Chemaly, Julian A. Villalba
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 58:208-215
Radiation-induced pulmonary fibrosis is a severe complication of patients treated with thoracic irradiation. We have previously shown that syndecan-2 reduces fibrosis by exerting alveolar epithelial cytoprotective effects. Here, we investigate whethe
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 54:25-33
Lipoxins (LX) are proresolving mediators that augment host defense against bacterial infection. Here, we investigated roles for LX in lung clearance of the fungal pathogen Cryptococcus neoformans (Cne). After intranasal inoculation of 5,000 CFU Cne,
Autor:
Caroline A. Owen, Christopher Royer, Maria E. Laucho-Contreras, Yohannes Tesfaigzi, Francesca Polverino, Melanie Doyle-Eisele, Jacob D. McDonald, Victor Pinto-Plata, Bartolome R. Celli, Joe L. Mauderly, Miguel Divo, Emer Kelly, Julie A. Wilder
Publikováno v:
The American Journal of Pathology. 185:741-755
Small animal models of chronic obstructive pulmonary disease (COPD) have several limitations for identifying new therapeutic targets and biomarkers for human COPD. These include a pulmonary anatomy that differs from humans, the limited airway patholo
Autor:
Eduarda Nilo de Magaldi, Sarah G. Chu, Souheil El-Chemaly, Ivan O. Rosas, Julie A. Wilder, Andrew P. Gigliotti, Cecilia Rietz, Hao Wang, Xiaomeng Tang, Jacob D. McDonald, Yuanyuan Shi, Melanie Doyle-Eisele, Gautam George, Raymond A. Guilmette, Ye Cui
Publikováno v:
Lymphatic Research and Biology. 12:238-250
The lymphatic vasculature has been shown to play important roles in lung injury and repair, particularly in lung fibrosis. The effects of ionizing radiation on lung lymphatic vasculature have not been previously reported.C57Bl/6 mice were immobilized
Autor:
Karen C. Goehring, Rachael Buck, Jeffery S. Oliver, Barbara J. Marriage, Edward G. Barrett, Julie A. Wilder
Publikováno v:
The Journal of nutrition. 146(12)
Background Evidence suggests that human milk oligosaccharides (HMOs) provide multiple benefits to infants, including prebiotic effects, gut maturation, antimicrobial activities, and immune modulation. Clinical intervention studies with HMOs are requi
Autor:
Janet M. Benson, Pramod S. Terse, Julie A. Wilder, Julie A. Hutt, Joshua C Grieger, Gensheng Wang, R. Jude Samulski, Christopher H. Evans, JeanClare Seagrave
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Interleukin-1 (IL-1) plays an important role in the pathophysiology of osteoarthritis (OA), and gene transfer of IL-1 receptor antagonist (IL-1Ra) holds promise for OA treatment. A preclinical safety and biodistribution study evaluated a self-complem
Autor:
Takwi Nkyimbeng, Julie A. Wilder, Joshua R. Sonett, Yuxia Jia, Divya Mehra, David I. Sternberg, Stephen M. Canfield, Jeanine D'Armiento, Vincent Lemaître
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 298:L189-L196
Matrix metalloproteinase-9 (MMP-9) is hypothesized to facilitate leukocyte extravasation and extracellular remodeling in asthmatic airways. Careful descriptive studies have shown that MMP-9 levels are higher in the sputum of asthmatics; however, the