Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Julie A. Tucker"'
Publikováno v:
Platelets, Vol 32, Iss 6, Pp 770-778 (2021)
Thrombopoietin (TPO) and its receptor, MPL, are the primary regulators of platelet production and critical for hematopoietic stem cell (HSC) maintenance. Since TPO was first cloned in 1994, the physiological and pathological roles of TPO and MPL have
Externí odkaz:
https://doaj.org/article/8a3d80fe6cdf48ee8e383d79b524fbb5
Autor:
Pamela A. Lochhead, Julie A. Tucker, Natalie J. Tatum, Jinhua Wang, David Oxley, Andrew M. Kidger, Victoria P. Johnson, Megan A. Cassidy, Nathanael S. Gray, Martin E. M. Noble, Simon J. Cook
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Selective ERK5 inhibitors target ERK5 kinase activity, but they do not phenocopy the effects of ERK5 genetic depletion. Here, the authors demonstrate that the direct interaction of these inhibitors to ERK5 kinase domain induces conformational changes
Externí odkaz:
https://doaj.org/article/74f91df61c624308a4815d6adcffb1f9
Autor:
Duncan C. Miller, Tristan Reuillon, Lauren Molyneux, Timothy Blackburn, Simon J. Cook, Noel Edwards, Jane A. Endicott, Bernard T. Golding, Roger J. Griffin, Ian Hardcastle, Suzannah J. Harnor, Amy Heptinstall, Pamela Lochhead, Mathew P. Martin, Nick C. Martin, Stephanie Myers, David R. Newell, Richard A. Noble, Nicole Phillips, Laurent Rigoreau, Huw Thomas, Julie A. Tucker, Lan-Zhen Wang, Michael J. Waring, Ai-Ching Wong, Stephen R. Wedge, Martin E. M. Noble, Celine Cano
Publikováno v:
Journal of Medicinal Chemistry. 65:6513-6540
The nonclassical extracellular signal-related kinase 5 (ERK5) mitogen-activated protein kinase pathway has been implicated in increased cellular proliferation, migration, survival, and angiogenesis; hence, ERK5 inhibition may be an attractive approac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88a06ab562a276985938cc66414c34c2
https://doi.org/10.1021/acs.jmedchem.1c01756
https://doi.org/10.1021/acs.jmedchem.1c01756
Autor:
Lan Z. Wang, Miller Duncan Charles, Bernard T. Golding, Ian Hickson, Martin E.M. Noble, Celine Cano, Suzannah J. Harnor, Michael J. Waring, Harry J Shrives, Shaimaa Khalifa, Jane Totobenazara, Stephen J. Hobson, Elaine Willmore, Hannah L Stewart, Mathew P. Martin, Susan J. Tudhope, Huw D. Thomas, Islam Al-Khawaldeh, Claire E. Jennings, João V de Souza, Max J. Temple, Jane A. Endicott, Cinzia Bordoni, Honorine Lebraud, Agnieszka K. Bronowska, Ian R. Hardcastle, Amy B. Heptinstall, Stephen R. Wedge, Christine Basmadjian, Gregory G Aldred, Julie A. Tucker, Mohammed J Al Yasiri
Publikováno v:
Journal of Medicinal Chemistry. 64:10001-10018
NF-κB-inducing kinase (NIK) is a key enzyme in the noncanonical NF-κB pathway, of interest in the treatment of a variety of diseases including cancer. Validation of NIK as a drug target requires potent and selective inhibitors. The protein contains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56300566066f33b5e78d20a96b537040
https://doi.org/10.1021/acs.jmedchem.0c01249
https://doi.org/10.1021/acs.jmedchem.0c01249
Autor:
Julie D. Tucker, John P. Baltrus, Ömer N. Doğan, Reyixiati Repukaiti, Douglas R. Kauffman, Richard P. Oleksak, Margaret Ziomek-Moroz, Lucas Teeter, Randal B. Thomas
Publikováno v:
Corrosion. 77:313-322
To understand the corrosion mechanisms of structural materials in low-temperature components of direct supercritical CO2 power cycles, immersion experiments were performed in aqueous environments expected at these conditions. A ferritic-martensitic s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1a1d6b56f2c6d2b4972486ceb40328f
https://doi.org/10.5006/3603
https://doi.org/10.5006/3603
Autor:
Pratik Murkute, Kofi Oware Sarfo, Isak McGieson, Melissa K. Santala, Yongfeng Zhang, Liney Árnadóttir, Julie D. Tucker, O. Burkan Isgor
Publikováno v:
SN Applied Sciences. 4
Despite their exceptional mechanical and corrosion properties, duplex stainless steels (DSS) have not found widespread use in high-temperature applications due to concerns over thermal aging and embrittlement at elevated operational temperatures (> 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76b69768683dde058d734aaacca798c3
https://doi.org/10.1007/s42452-022-04978-1
https://doi.org/10.1007/s42452-022-04978-1
Publikováno v:
Biochemical Society Transactions
ERK5 is a protein kinase that also contains a nuclear localisation signal and a transcriptional transactivation domain. Inhibition of ERK5 has therapeutic potential in cancer and inflammation and this has prompted the development of ERK5 kinase inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cbec5a58dc1d1c58b3e925901d94ea9
http://europepmc.org/articles/PMC7609025
http://europepmc.org/articles/PMC7609025
Autor:
Natalie J. Tatum, Megan A Cassidy, Pamela A. Lochhead, David Oxley, Julie A. Tucker, Victoria P Johnson, Andrew M. Kidger, Simon J. Cook, Martin E.M. Noble, Nathanael S. Gray, Jinhua Wang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Nature Communications
The dual protein kinase-transcription factor, ERK5, is an emerging drug target in cancer and inflammation, and small-molecule ERK5 kinase inhibitors have been developed. However, selective ERK5 kinase inhibitors fail to recapitulate ERK5 genetic abla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8580ed52562132fb3cdff6c6b5715a6
http://link.springer.com/article/10.1038/s41467-020-15031-3
http://link.springer.com/article/10.1038/s41467-020-15031-3
Autor:
Laurent Capolungo, Fei Teng, B.P. Eftink, Matthew M. Schneider, Stuart A. Maloy, Peter Hosemann, H.T. Vo, Julie D. Tucker, Khanh Dang
Publikováno v:
Materials & Design, Vol 207, Iss, Pp 109820-(2021)
Nickel-based alloys are extensively used in a wide range of extreme environments because of their exceptional mechanical properties. The excellent strength of these alloys is derived from the addition of long-range ordered precipitates, introduced by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34b6282ce875438b871dd823050a2432
http://www.sciencedirect.com/science/article/pii/S0264127521003737
http://www.sciencedirect.com/science/article/pii/S0264127521003737
Autor:
Jia-Hong Ke, Julie D. Tucker
Publikováno v:
Computational Materials Science. 214:111768
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d28f34e1ec579013fe5ce1b466270f7
https://doi.org/10.1016/j.commatsci.2022.111768
https://doi.org/10.1016/j.commatsci.2022.111768