Výsledky vyhledávání - "Julie A. Pittman"

Analysis of clonotypic switch junctions reveals multiple myeloma originates from a single class switch event with ongoing mutation in the isotype-switched progeny

Autor: Jitra Kriangkum, Michael J. Mant, Andrew Belch, Linda M. Pilarski, Brian J. Taylor, Tony Reiman, Julie A. Pittman

Publikováno v: Blood. 112:1894-1903

Multiple myeloma (MM) is a cancer of plasma cells (PCs) expressing immunoglobulin heavy chain (IgH) postswitch isotypes. The discovery of earlier stage cells related to postswitch PCs, called preswitch clonotypic IgM (cIgM) cells led to the hypothesi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35b47a384db7be593cb0c3b281447368
https://doi.org/10.1182/blood-2008-01-129221

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SSX cancer testis antigens are expressed in most multiple myeloma patients: co-expression of SSX1, 2, 4, and 5 correlates with adverse prognosis and high frequencies of SSX-positive PCs

Autor: Jonathan J Keats, Tony Reiman, Julie A. Pittman, Andrew R. Belch, Brian J. Taylor, Linda M. Pilarski, Diederik R.H. de Bruijn, Michael J. Mant

Publikováno v: Journal of Immunotherapy (1997), 28, 6, pp. 564-75
Journal of Immunotherapy (1997), 28, 564-75

Contains fulltext : 48545.pdf (Publisher’s version ) (Closed access) Cancer testis antigens (CTAs) are tumor-specific antigens that may be useful targets for cancer vaccines. Here, CTA expression was examined in multiple myeloma (MM), a B-cell canc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb8113529d021d65b6ca7d5eb279e598
https://hdl.handle.net/2066/48545

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VDJ-Switch Region Analysis in Multiple Myeloma Patients Reveals Homogeneity and Long-Term Stability of Switch Junctions, and Ongoing Mutation Upstream of Switch Mu

Autor: Linda M. Pilarski, Andrew R. Belch, Julie A. Pittman, Brian J. Taylor

Publikováno v: Blood. 104:1414-1414

During class switch recombination (CSR) B cells change their immunoglobulin heavy chain (IgH) constant region genes by a deletional recombination mechanism involving well characterized switch (S) regions several Kb downstream of IgH variable region (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4f0acd051e5e3242926a8d157d3a5644
https://doi.org/10.1182/blood.v104.11.1414.1414

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