Distinct structural features of G protein-coupled receptor kinase 5 (GRK5) regulate its nuclear localization and DNA-binding ability.

Autor: Laura R Johnson, James D Robinson, Katrina N Lester, Julie A Pitcher

Publikováno v: PLoS ONE, Vol 8, Iss 5, p e62508 (2013)

G protein-coupled receptor kinases (GRKs) act to desensitize G protein-coupled receptors (GPCRs). In addition to this role at the plasma membrane, a nuclear function for GRK5, a member of the GRK4 subfamily of GRKs, has been reported. GRK5 phosphoryl

Externí odkaz: https://doaj.org/article/945a853b8ff84e6c91fb0b6cdb8e6860

Cooperative Regulation of Extracellular Signal-Regulated Kinase Activation and Cell Shape Change by Filamin A and β-Arrestins

Autor: Alain Thuret, Olivier Muntaner, Mark G.H. Scott, Vincenzo Pierotti, Julie A. Pitcher, Stephano Marullo, Hélène Storez, Catherine Labbé-Jullié, Erika Lindberg

Publikováno v: Molecular and Cellular Biology
Molecular and Cellular Biology, American Society for Microbiology, 2006, 26, pp.3432-45. 〈10.1128/MCB.26.9.3432-3445.2006〉

14 pages; beta-Arrestins (betaarr) are multifunctional adaptor proteins that can act as scaffolds for G protein-coupled receptor activation of mitogen-activated protein kinases (MAPK). Here, we identify the actin-binding and scaffolding protein filam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::677aec621a24a5a0fc301a20e8f7b51a
https://doi.org/10.1128/mcb.26.9.3432-3445.2006

Purification, crystallization and preliminary X-ray diffraction studies of a complex between G protein-coupled receptor kinase 2 and Gβ1γ2

Autor: Jennifer F. Barnhill, Julie A. Pitcher, David T. Lodowski, W. Darrell Capel, Robert J. Lefkowitz, John J.G. Tesmer

Publikováno v: Acta Crystallographica Section D Biological Crystallography. 59:936-939

G protein-coupled receptor kinase 2 (GRK2) phosphorylates activated G protein-coupled receptors (GPCRs), which ultimately leads to their desensitization and/or downregulation. The enzyme is recruited to the plasma membrane via the interaction of its

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecb26afa5a3496700c7b4f7ead714960
https://doi.org/10.1107/s0907444903002622

The diverse roles of G protein-coupled receptor kinase 2 (GRK2): a focus on regulation of receptor tyrosine kinases (RTKs)

Autor: James D. Robinson, Julie A. Pitcher

Publikováno v: Receptors & Clinical Investigation.

The G protein-coupled receptor (GPCR) kinases (GRKs) are a family of seven serine/threonine kinases that are recruited to and activated by almost all agonist-occupied GPCRs. Upon recruitment and activation, GRK2 inhibits G protein-dependent signaling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1a2ab3e72dbd37576d468638195ba058
https://doi.org/10.14800/rci.166

Identification of NSF as a β-Arrestin1-binding Protein

Autor: Robert J. Lefkowitz, Fang-Tsyr Lin, Nicole L. Cote, Richard T. Premont, Julie A. Pitcher, Patricia McDonald

Publikováno v: Journal of Biological Chemistry. 274:10677-10680

Previous studies have demonstrated that beta-arrestin1 serves to target G protein-coupled receptors for internalization via clathrin-coated pits and that its endocytic function is regulated by dephosphorylation at the plasma membrane. Using the yeast

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0ac45d7e0f7b4248df12c80dec757462
https://doi.org/10.1074/jbc.274.16.10677