Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Julie A. Moreno"'
Autor:
Devin Wahl, Sydney J. Risen, Shelby C. Osburn, Tobias Emge, Sadhana Sharma, Vincenzo S. Gilberto, Anushree Chatterjee, Prashant Nagpal, Julie A. Moreno, Thomas J. LaRocca
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-18 (2024)
Abstract Neuroinflammation contributes to impaired cognitive function in brain aging and neurodegenerative disorders like Alzheimer’s disease, which is characterized by the aggregation of pathological tau. One major driver of both age- and tau-asso
Externí odkaz:
https://doaj.org/article/5605af35a84d4c0f8db032124aca9f4d
Publikováno v:
Frontiers in Aging, Vol 4 (2023)
Neuroinflammation is a universal characteristic of brain aging and neurological disorders, irrespective of the disease state. Glial inflammation mediates this signaling, through astrocyte and microglial polarization from neuroprotective to neurotoxic
Externí odkaz:
https://doaj.org/article/008469a5056f4a7c8be1e3b96ec7765a
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Prion diseases are characterized by the cellular prion protein, PrPC, misfolding and aggregating into the infectious prion protein, PrPSc, which leads to neurodegeneration and death. An early sign of disease is inflammation in the brain and
Externí odkaz:
https://doaj.org/article/40b3cccd4fea4e9b9beffef7ea13dac9
Autor:
Amanda S. Latham, Charlize E. Geer, David F. Ackart, Isla K. Anderson, Kaley M. Vittoria, Brendan K. Podell, Randall J. Basaraba, Julie A. Moreno
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Tuberculosis, caused by Mycobacterium tuberculosis infection, is an ongoing epidemic with an estimated ten million active cases of the disease worldwide. Pulmonary tuberculosis is associated with cognitive and memory deficits, and patients with this
Externí odkaz:
https://doaj.org/article/0dc3cb2aa699433f855868582cd2883e
Autor:
Arielle J. D. Hay, Amanda S. Latham, Genova Mumford, Amelia D. Hines, Sydney Risen, Elizabeth Gordon, Connor Siebenaler, Vincenzo S. Gilberto, Mark D. Zabel, Julie A. Moreno
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Mesenchymal stromal cells (MSCs) are an intriguing avenue for the treatment of neurological disorders due to their ability to migrate to sites of neuroinflammation and respond to paracrine signaling in those sites by secreting cytokines, growth facto
Externí odkaz:
https://doaj.org/article/dc6fcc63d1044053ab6439989e38bd95
Autor:
Luke W. Desmond, Evan M. Holbrook, Caelan T. O. Wright, Cristian A. Zambrano, Christopher E. Stamper, Adam D. Bohr, Matthew G. Frank, Brendan K. Podell, Julie A. Moreno, Andrew S. MacDonald, Stefan O. Reber, Rogelio Hernández-Pando, Christopher A. Lowry
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 1, p 474 (2023)
Previous studies have shown that the in vivo administration of soil-derived bacteria with anti-inflammatory and immunoregulatory properties, such as Mycobacterium vaccae NCTC 11659, can prevent a stress-induced shift toward an inflammatory M1 microgl
Externí odkaz:
https://doaj.org/article/abb6d4b1e77f49f48cc78f58e0ffac8e
Autor:
Amelia D. Hines, Stephanie McGrath, Amanda S. Latham, Breonna Kusick, Lisa Mulligan, McKenzie L. Richards, Julie A. Moreno
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
Canine cognitive dysfunction (CCD) syndrome is a well-recognized naturally occurring disease in aged dogs, with a remarkably similar disease course, both in its clinical presentation and neuropathological changes, as humans with Alzheimer’s disease
Externí odkaz:
https://doaj.org/article/665191882b2a453aa6a11713bea4adea
Publikováno v:
Frontiers in Veterinary Science, Vol 9 (2022)
ObjectivesThe aim of this study was to investigate the potential risk factors involved in the development of presumptive advanced canine cognitive dysfunction (pACCD).Materials and methodsA questionnaire was developed to identify dogs with presumptiv
Externí odkaz:
https://doaj.org/article/0e7bc78066df43e59a299e32aa0d3d35
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
Alzheimer’s disease (AD) is the leading cause of dementia and one of the most common causes of death worldwide. As an age-dependent multifactorial disease, the causative triggers of AD are rooted in spontaneous declines in cellular function and met
Externí odkaz:
https://doaj.org/article/3cc2ed1eee3244478905563c69f3d296
Autor:
Devin Wahl, Julie A Moreno, Kelly S Santangelo, Qian Zhang, Maryam F Afzali, Maureen A Walsh, Robert V Musci, Alyssa N Cavalier, Karyn L Hamilton, Thomas J LaRocca
Publikováno v:
J Gerontol A Biol Sci Med Sci
Older age is the primary risk factor for most chronic diseases, including Alzheimer’s disease (AD). Current preclinical models to study brain aging and AD are mainly transgenic and harbor mutations intended to mirror brain pathologies associated wi