Výsledky vyhledávání - "Julie A. Merriman"

Akademický článek

Loss of GGN leads to pre-implantation embryonic lethality and compromised male meiotic DNA double strand break repair in the mouse.

Autor: Duangporn Jamsai, Anne E O'Connor, Kathleen D Deboer, Brett J Clark, Stephanie J Smith, Catherine M Browne, Jonathan G Bensley, Julie A Merriman, Wai Shan Yuen, Peter Koopman, Keith T Jones, Moira K O'Bryan

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e56955 (2013)

The integrity of male germ cell genome is critical for the correct progression of spermatogenesis, successful fertilization, and proper development of the offspring. Several DNA repair pathways exist in male germ cells. However, unlike somatic cells,

Externí odkaz: https://doaj.org/article/d7a0f0a865394e3486e2c03857a7f8d2

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Akademický článek

DNA double strand breaks but not interstrand crosslinks prevent progress through meiosis in fully grown mouse oocytes.

Autor: Wai Shan Yuen, Julie A Merriman, Moira K O'Bryan, Keith T Jones

Publikováno v: PLoS ONE, Vol 7, Iss 8, p e43875 (2012)

There is some interest in how mammalian oocytes respond to different types of DNA damage because of the increasing expectation of fertility preservation in women undergoing chemotherapy. Double strand breaks (DSBs) induced by ionizing radiation and a

Externí odkaz: https://doaj.org/article/3111bf98757e4f12b0474ea4fe5d8f61

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FACS-sorted putative oogonial stem cells from the ovary are neither DDX4-positive nor germ cells

Autor: Julie A. Merriman, Keith T. Jones, Simon I. R. Lane, Larissa Zarate-Garcia

Publikováno v: Scientific Reports

Whether the adult mammalian ovary contains oogonial stem cells (OSCs) is controversial. They have been isolated by a live-cell sorting method using the germ cell marker DDX4, which has previously been assumed to be cytoplasmic, not surface-bound. Fur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cebfcc54a42659eac2af206e2b60a48

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DNA damage induces a meiotic arrest in mouse oocytes mediated by the spindle assembly checkpoint

Autor: Keith T. Jones, Simon I. R. Lane, Josie K. Collins, Julie A. Merriman

Publikováno v: Nature Communications

Extensive damage to maternal DNA during meiosis causes infertility, birth defects and abortions. However, it is unknown if fully grown oocytes have a mechanism to prevent the creation of DNA-damaged embryos. Here we show that DNA damage activates a p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96ffcdff09682017323bf69949f6ff9c
https://eprints.soton.ac.uk/383430/

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Reduced ability to recover from spindle disruption and loss of kinetochore spindle assembly checkpoint proteins in oocytes from aged mice

Autor: Keith T. Jones, Janet E. Holt, Simon I. R. Lane, Julie A. Merriman, Eileen A. McLaughlin, Yan Yun

Publikováno v: Cell cycle (Georgetown, Tex.). 13(12)

Currently, maternal aging in women, based on mouse models, is thought to raise oocyte aneuploidy rates, because chromosome cohesion deteriorates during prophase arrest, and Sgo2, a protector of centromeric cohesion, is lost. Here we show that the mos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86909187990a29569fd13b4578c375ff
https://pubmed.ncbi.nlm.nih.gov/24758999

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Reduced Chromosome Cohesion Measured by Interkinetochore Distance Is Associated with Aneuploidy Even in Oocytes from Young Mice1

Autor: Keith T. Jones, Irene García-Higuera, Sergio Moreno, Eileen A. McLaughlin, Julie A. Merriman, Janet E. Holt, Phoebe C. Jennings, Simon I. R. Lane

Publikováno v: Biology of Reproduction. 88

It is becoming clear that reduced chromosome cohesion is an important factor in the rise of maternal age-related aneuploidy. This reduction in cohesion has been observed both in human and mouse oocytes, and it can be measured directly by an increase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f0a642992ac284f218d869b7c47880e5
https://doi.org/10.1095/biolreprod.112.104786

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