Výsledky vyhledávání - "Julie A. McCarron"

Synthesis and initial evaluation of [C-11](R)-RWAY in monkey - a new, simply labeled antagonist radioligand for imaging brain 5-HT1A receptors with PET

Autor: Victor W. Pike, Julie A. McCarron, H. Umesha Shetty, Masanori Ichise, Christer Halldin, Håkan Wikström, Sami S. Zoghbi, Fumihiko Yasuno, E. S. Vermeulen, Robert B. Innis

Publikováno v: European Journal of Nuclear Medicine and Molecular Imaging, 34(10), 1670-1682. SPRINGER

Purpose We aimed to fulfill a need for a radioligand that may be simply labeled with carbon-11 for effective positron emission tomography (PET) imaging of brain 5-HT1A receptors.Methods Racemic RWAY (2,3,4,5,6,7-hexahydro-1-[4-[1-[4-(2-methoxyphenyl)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10ba54f5c043d7cb1b3293a7c56db22c
https://doi.org/10.1007/s00259-007-0460-z

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Effect of a P-glycoprotein inhibitor, cyclosporin A, on the disposition in rodent brain and blood of the 5-HT1A receptor radioligand, [11C](R)-(––)-RWAY

Autor: Julie A. McCarron, Robert B. Innis, Jeih-San Liow, John L. Musachio, Jinsoo Hong, Sami S. Zoghbi, Victor W. Pike, Shuiyu Lu

Publikováno v: Synapse. 61:96-105

Limited brain uptake of radioligands with otherwise optimal properties for imaging brain receptors can be improved by blocking the effect of P-glycoprotein (P-gp), an efflux pump at the blood-brain barrier. Using small animal positron emission tomogr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d3926d8745e057344de5070397ebc7e
https://doi.org/10.1002/syn.20348

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EfficientO- andN-(β-fluoroethylation)s with NCA[18F]β-fluoroethyl tosylate under microwave-enhanced conditions

Autor: Shuiyu Lu, Victor W. Pike, Julie A. McCarron, Frederick T. Chin

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 47:289-297

Reactions of no-carrier-added (NCA) [18F]β-fluoroethyl tosylate with amine, phenol or carboxylic acid to form the corresponding [18F]N-(β-fluoroethyl)amine, [18F]β-fluoroethyl ether or [18F]β-fluoroethyl ester, were found to be rapid (2–10 min)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::784ee1dc3b0190491947e532811f8ab1
https://doi.org/10.1002/jlcr.818

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Synthesis of no-carrier-added [11C]methanesulfonyl chloride as a new labeling agent for PET radiopharmaceutical development

Autor: Julie A. McCarron, Victor W. Pike

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 46:1127-1140

Three methods are described for labeling methanesulfonyl (mesyl) chloride with no-carrier-added (NCA) carbon-11 (t1/2=20.4 min; β+=99.8%) to provide a new labeling agent of potential value in radiopharmaceutical development for positron emission tom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b4f17a529f9c31b98f21be6fbdd6899b
https://doi.org/10.1002/jlcr.745

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Radioligands for the study of brain 5-HT1A receptors in vivo–development of some new analogues of way

Autor: S Marchais, Julie A. McCarron, Lars Farde, Håkan Wikström, Susan P. Hume, Maria Constantinou, Safiye Osman, Victor W. Pike, Bengt Andrée, Bartek Nowicki, Carl-Gunnar Swahn, Christer Halldin, Johan Sandell

Publikováno v: Nuclear Medicine and Biology. 27:449-455

ABSTRACT. [ Carbonyl - 11 C]WAY-100635 (WAY) has proved to be a very useful radioligand for the imaging of brain 5-HT 1A receptors in human brain in vivo with positron emission tomography (PET). WAY is now being applied widely for clinical research a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a2a1f9f686300e3360f8ff2f0b8fffe
https://doi.org/10.1016/s0969-8051(00)00110-4

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PET-characterization of [ carbonyl - 11 C]WAY-100635 binding to 5-HT 1A receptors in the primate brain

Autor: Nathalie Ginovart, Hiroshi Ito, Christer Halldin, Julie A. McCarron, Lars Farde, Victor W. Pike, Camilla Lundkvist

Publikováno v: Psychopharmacology. 133:196-202

[carbonyl-11C]WAY-100635 is a new radioligand which can be used with positron emission tomography (PET) to provide high contrast delineation of human brain regions that are rich in 5-HT1A receptors. In the present PET study, the binding of [carbonyl-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f182b74dafdeb54933e4a6739ec0a1c0
https://doi.org/10.1007/s002130050391

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Remotely-controlled production of the 5-HT1A receptor radioligand, [carbonyl-11C]WAY-100635, via 11C-carboxylation of an immobilized Grignard reagent

Autor: Julie A. McCarron, David R. Turton, Keith G. Poole, Victor W. Pike

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 38:941-953

WAY-100635 [N-(2-(1-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl))-N-(2-pyridyl)-cyclohexanecarboxamide], when labelled in its carbonyl position with carbon-11 (t 1/2 = 20.4 min), is an effective radioligand for the study of 5-HT 1A receptors in human br

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d45dc9e3c5222548ce945918ce586050
https://doi.org/10.1002/(sici)1099-1344(199610)38:10<941::aid-jlcr906>3.0.co

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Quantification of serotonin 5-HT1A receptors in humans with [11C](R)-(-)-RWAY: radiometabolite(s) likely confound brain measurements

Autor: Victor W. Pike, Sami S. Zoghbi, Fumihiko Yasuno, Jeih-San Liow, Julie A. McCarron, Xiang-Yang Zhang, Robert B. Innis, Jinsoo Hong

Publikováno v: Synapse (New York, N.Y.). 61(7)

C)(R)-(� )-RWAY has been shown to be a promising radioligand for imaging brain 5-HT1A receptors with positron emission tomography in rodents and nonhuman primates. We now report the first use of ( 11 C)(R)-(� )-RWAY in six healthy human subjects,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b69e2bedf02f73add9f5d6c40f27519d
https://pubmed.ncbi.nlm.nih.gov/17415792

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