Výsledky vyhledávání - "Julie A. Losman"

Akademický článek

Secondary IDH1 resistance mutations and oncogenic IDH2 mutations cause acquired resistance to ivosidenib in cholangiocarcinoma

Autor: James M. Cleary, Betty Rouaisnel, Antoine Daina, Srivatsan Raghavan, Lauren A. Roller, Brandon M. Huffman, Harshabad Singh, Patrick Y. Wen, Nabeel Bardeesy, Vincent Zoete, Brian M. Wolpin, Julie-Aurore Losman

Publikováno v: npj Precision Oncology, Vol 6, Iss 1, Pp 1-8 (2022)

Abstract The mutant IDH1 inhibitor ivosidenib improves outcomes for patients with IDH1-mutated cholangiocarcinoma, but resistance inevitably develops. Mechanisms of resistance and strategies to overcome resistance are poorly understood. Here we descr

Externí odkaz: https://doaj.org/article/962a66f0229c419b9c0baf617a38cea3

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Akademický článek

Regulation of neuroendocrine plasticity by the RNA-binding protein ZFP36L1

Autor: Hsiao-Yun Chen, Yavuz T. Durmaz, Yixiang Li, Amin H. Sabet, Amir Vajdi, Thomas Denize, Emily Walton, Yasmin Nabil Laimon, John G. Doench, Navin R. Mahadevan, Julie-Aurore Losman, David A. Barbie, Michael Y. Tolstorukov, Charles M. Rudin, Triparna Sen, Sabina Signoretti, Matthew G. Oser

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)

LSD1 inhibition blocks the neuroendocrine phenotype of some small cell lung cancers (SCLCs). Here, a genome-wide CRISPR/Cas9 LSD1 inhibitor resistance screen identifies the mRNA-binding protein ZFP36L1 as a gene repressed by LSD1 that when restored i

Externí odkaz: https://doaj.org/article/7672bb9231c144b3a01d9383ed50542c

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