Výsledky vyhledávání - "Julie A. Lekstrom-Himes"

Safety, Pharmacokinetics and Immune Effects in Normal Volunteers of CPG 10101 (ACTILON™), an Investigational Synthetic Toll-like Receptor 9 Agonist

Autor: Mary Louise Morris, Julie A. Lekstrom-Himes, Arthur M. Krieg, Heather L. Davis, Philip Leese, Chantal Laframboise, Alain Vicari, Mohammed J Al-Adhami, Susan M. Efler, Tess Schmalbach

Publikováno v: Antiviral Therapy. 12:741-751

CPG 10101 (ACTILON™) is a novel potent and selective unmethylated cytidine-phosphate-guanosine (CpG)-containing oligodeoxynucleotide agonist of Toll-like receptor 9 (TLR9) being developed for the treatment of chronic infections such as HCV.Objectiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::361bf1720f203cb76d0327921c25bbf7
https://doi.org/10.1177/135965350701200501

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Human neutrophil collagenase expression is C/EBP-dependent during myeloid development

Autor: Vincent Idone, Theresa Zibello, Arati Khanna-Gupta, Julie A. Lekstrom-Himes, Hong Sun, Nancy Berliner

Publikováno v: Experimental Hematology. 33:42-52

Objective Human neutrophil collagenase (HNC) is one of several secondary granule proteins (SGP) expressed late in the myeloid maturation pathway. SGPs are encoded by unlinked and functionally diverse genes that are hypothesized to be coordinately reg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e0d2aa05c2ac99549ee918f4b99c82f
https://doi.org/10.1016/j.exphem.2004.09.009

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Enhancement of Hematopoietic Stem Cell Repopulating Capacity and Self-Renewal in the Absence of the Transcription Factor C/EBPα

Autor: Pu Zhang, Koichi Akashi, Hirokazu Shigematsu, Elena Levantini, Julie A. Lekstrom-Himes, Hiromi Iwasaki, Daniel G. Tenen, Junko Iwasaki-Arai, Bronwyn M. Owens, Tajhal Dayaram, Maris Fenyus, Claudia S. Huettner

Publikováno v: Immunity. 21:853-863

The transcription factor C/EBP alpha is required for granulopoiesis and frequently disrupted in human acute myeloid leukemia (AML). Here, we show disruption of C/EBP alpha blocks the transition from the common myeloid to the granulocyte/monocyte prog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d27a1b5812b02c3bcee740becfbf725f
https://doi.org/10.1016/j.immuni.2004.11.006

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Novel Combinatorial Interactions of GATA-1, PU.1, and C/EBPε Isoforms Regulate Transcription of the Gene Encoding Eosinophil Granule Major Basic Protein

Autor: Monika J. Stankiewicz, Qing Xi, Jonathan E. Schmitz, Yang Liu, Julie A. Lekstrom-Himes, Steven J. Ackerman, Jian Du

Publikováno v: Journal of Biological Chemistry. 277:43481-43494

GATA-1 and the ets factor PU.1 have been reported to functionally antagonize one another in the regulation of erythroid versus myeloid gene transcription and development. The CCAAT enhancer binding protein epsilon (C/EBPepsilon) is expressed as multi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd5d677759fb5a2ebcbe5fc86d4c0dbd
https://doi.org/10.1074/jbc.m204777200

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Molecular analysis of the mouse S100A9 gene and evidence that the myeloid specific transcription factor C/EBPepsilon is not required for the regulation of the S100A9/A8 gene expression in neutrophils

Autor: Wolfgang Nacken, Julie A. Lekstrom-Himes, Marie Pierre Manitz, Clemens Sorg

Publikováno v: Journal of Cellular Biochemistry. 80:606-616

The genomic locus of the mouse S100A9 (MRP14) gene, a myeloid expressed gene belonging to the S100 family, is split in three exons and two introns. Insertions of B1 like and LINE elements as well as several sequence repeat structures are scattered ov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d5203d75c5820ae9e0bbcffdd0f9af09
https://doi.org/10.1002/1097-4644(20010315)80:4<606::aid-jcb1015>3.0.co

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Gamma Interferon Impedes the Establishment of Herpes Simplex Virus Type 1 Latent Infection but Has No Impact on Its Maintenance or Reactivation in Mice

Autor: Julie A. Lekstrom-Himes, Matthew Godleski, Lesley Pesnicak, Sharon E. Straus, Rona A. LeBlanc

Publikováno v: Journal of Virology. 74:6680-6683

Murine models of gamma interferon (IFN-γ) deficiency demonstrate the role of this cytokine in attenuating acute herpes simplex virus (HSV) disease; however, the effect of IFN-γ on the establishment and maintenance of neuronal latency and viral reac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcc92c2cdbd9d09dd7681796096dd13f
https://doi.org/10.1128/jvi.74.14.6680-6683.2000

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Inherited Neutrophil Disorders

Autor: David C. Dale, Mary C. Dinauer, Julie A. Lekstrom-Himes

Publikováno v: Hematology. 2000:303-318

Recent advances in our understanding of the molecular basis of inherited neutrophil disorders and complementary studies in transgenic mouse models have provided new insights into the normal mechanisms regulating myelopoiesis and the functional respon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ad23da56442c27c275342b5af4992cc
https://doi.org/10.1182/asheducation.v2000.1.303.20000303

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Inherited Neutrophil Disorders: Molecular Basis and New Therapies

Autor: David C. Dale, Julie A. Lekstrom-Himes, Mary C. Dinauer

Publikováno v: Hematology. 2000:303-318

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcba5fb09233138d31c58f88a10d439a
https://doi.org/10.1182/asheducation-2000.1.303

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Neutrophil-specific Granule Deficiency Results from a Novel Mutation with Loss of Function of the Transcription Factor CCAAT/Enhancer Binding Protein ε

Autor: Piroska Kopar, Steven M. Holland, John I. Gallin, Julie A. Lekstrom-Himes, Susan E. Dorman

Publikováno v: The Journal of Experimental Medicine

Neutrophil-specific granule deficiency (SGD) is a rare disorder characterized by recurrent pyogenic infections, defective neutrophil chemotaxis and bactericidal activity, and lack of neutrophil secondary granule proteins. CCAAT/enhancer binding prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df940bf73aea76ed3dabd7a6d1f8a96b
https://doi.org/10.1084/jem.189.11.1847

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