Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Julie A. Irving"'
Autor:
Jayaram Vijayakrishnan, James Studd, Peter Broderick, Ben Kinnersley, Amy Holroyd, Philip J. Law, Rajiv Kumar, James M. Allan, Christine J. Harrison, Anthony V. Moorman, Ajay Vora, Eve Roman, Sivaramakrishna Rachakonda, Sally E. Kinsey, Eamonn Sheridan, Pamela D. Thompson, Julie A. Irving, Rolf Koehler, Per Hoffmann, Markus M. Nöthen, Stefanie Heilmann-Heimbach, Karl-Heinz Jöckel, Douglas F. Easton, Paul D. P. Pharaoh, Alison M. Dunning, Julian Peto, Frederico Canzian, Anthony Swerdlow, Rosalind A. Eeles, ZSofia Kote-Jarai, Kenneth Muir, Nora Pashayan, The PRACTICAL Consortium, Mel Greaves, Martin Zimmerman, Claus R. Bartram, Martin Schrappe, Martin Stanulla, Kari Hemminki, Richard S. Houlston
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
While GWAS have uncovered susceptibility loci for B-cell precursor acute lymphoblastic leukemia (BCP-ALL), much of the heritable risk remains undiscovered. Here, the authors perform a meta-analysis of two existing BCP-ALL GWAS together with an unpubl
Externí odkaz:
https://doaj.org/article/6a850276ab0d4ba1a6215db9280b774f
Autor:
Jayaram Vijayakrishnan, James Studd, Peter Broderick, Ben Kinnersley, Amy Holroyd, Philip J. Law, Rajiv Kumar, James M. Allan, Christine J. Harrison, Anthony V. Moorman, Ajay Vora, Eve Roman, Sivaramakrishna Rachakonda, Sally E. Kinsey, Eamonn Sheridan, Pamela D. Thompson, Julie A. Irving, Rolf Koehler, Per Hoffmann, Markus M. Nöthen, Stefanie Heilmann-Heimbach, Karl-Heinz Jöckel, Douglas F. Easton, Paul D. P. Pharaoh, Alison M. Dunning, Julian Peto, Frederico Canzian, Anthony Swerdlow, Rosalind A. Eeles, Zsofia Kote-Jarai, Kenneth Muir, Nora Pashayan, The PRACTICAL consortium, Mel Greaves, Martin Zimmerman, Claus R. Bartram, Martin Schrappe, Martin Stanulla, Kari Hemminki, Richard S. Houlston
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-3 (2019)
The original version of this Article contained an error in the spelling of a member of the PRACTICAL Consortium, Manuela Gago-Dominguez, which was incorrectly given as Manuela Gago Dominguez. This has now been corrected in both the PDF and HTML versi
Externí odkaz:
https://doaj.org/article/3b6f8efa9fc34ebcb4db4d75611e74bc
Autor:
Felix K.F. Kommoss, Sarah Chiang, Martin Köbel, Christian Koelsche, Kenneth Tou-En Chang, Julie A. Irving, Brendan Dickson, Sakinah Thiryayi, Marjan Rouzbahman, Golnar Rasty, Andreas von Deimling, Cheng-Han Lee, Gulisa Turashvili
Publikováno v:
American Journal of Surgical Pathology. 46:1142-1152
The distinction between low-grade and high-grade endometrial stromal sarcomas (LGESS, HGESS) is increasingly defined by genetics. Recently, variant genomic alterations involving BCOR or BCORL1 have been reported in endometrial stromal sarcoma (ESS),
Autor:
Elizabeth C. Matheson, Huw Thomas, Marian Case, Helen Blair, Rosanna K. Jackson, Dino Masic, Gareth Veal, Chris Halsey, David R. Newell, Josef Vormoor, Julie A.E. Irving
Publikováno v:
Haematologica, Vol 104, Iss 9 (2019)
New drugs are needed for the treatment of relapsed acute lymphoblastic leukemia and preclinical evaluation of the MEK inhibitor, selumetinib, has shown that this drug has excellent activity in those leukemias with RAS pathway mutations. The proapopto
Externí odkaz:
https://doaj.org/article/4c98742e670c4bd7b057204de6188653
Autor:
Julie A.E. Irving, Andrew G. Hall, Josef Vormoor, Simon Bailey, Nick Bown, Christine J. Harrison, Rosline Hassan, Lynne Minto, Elizabeth Matheson, Marian Case
Deregulation of the RAS-RAF-mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) kinase (MEK)-ERK signaling cascade is often caused by somatic mutations in genes encoding proteins which influence the activity of this pathway a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fee3ab4b4c8826af7c0cd1260b59b67
https://doi.org/10.1158/0008-5472.c.6496418
https://doi.org/10.1158/0008-5472.c.6496418
Autor:
Julie A.E. Irving, Andrew G. Hall, Josef Vormoor, Simon Bailey, Nick Bown, Christine J. Harrison, Rosline Hassan, Lynne Minto, Elizabeth Matheson, Marian Case
Supplementary Table 3 from Mutation of Genes Affecting the RAS Pathway Is Common in Childhood Acute Lymphoblastic Leukemia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b0aa6e342e03848258b0e226641a1f9
https://doi.org/10.1158/0008-5472.22370486
https://doi.org/10.1158/0008-5472.22370486
Glucocorticoids are pivotal in the treatment of children with acute lymphoblastic leukemia (ALL) and have significant antileukemic effects in the majority of children. However, clinical resistance is a significant problem. Although cell line models i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a907dd34942bf8cfa44c87bce7c4ecb0
https://doi.org/10.1158/0008-5472.c.6496070
https://doi.org/10.1158/0008-5472.c.6496070
Autor:
Julie A.E. Irving, Andrew G. Hall, Josef Vormoor, Simon Bailey, Nick Bown, Christine J. Harrison, Rosline Hassan, Lynne Minto, Elizabeth Matheson, Marian Case
Supplementary Table 2 from Mutation of Genes Affecting the RAS Pathway Is Common in Childhood Acute Lymphoblastic Leukemia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0da64287d43e2de90fbb17df16c0dfed
https://doi.org/10.1158/0008-5472.22370489.v1
https://doi.org/10.1158/0008-5472.22370489.v1
Primer details and DHPLC conditions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22d1bce4470404cbd9881010945de8cf
https://doi.org/10.1158/0008-5472.22368686.v1
https://doi.org/10.1158/0008-5472.22368686.v1
Autor:
Julie A.E. Irving, Andrew G. Hall, Josef Vormoor, Simon Bailey, Nick Bown, Christine J. Harrison, Rosline Hassan, Lynne Minto, Elizabeth Matheson, Marian Case
Supplementary Table 1 from Mutation of Genes Affecting the RAS Pathway Is Common in Childhood Acute Lymphoblastic Leukemia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28cbe7ea71ab8a1c5deeecce7b523d4b
https://doi.org/10.1158/0008-5472.22370492.v1
https://doi.org/10.1158/0008-5472.22370492.v1