Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Julie A. Farley"'
Autor:
Benjamin R. Cassidy, Sreemathi Logan, Julie A. Farley, Daniel B. Owen, William E. Sonntag, Douglas A. Drevets
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundNeuro-cognitive impairment is a deleterious complication of bacterial infections that is difficult to treat or prevent. Listeria monocytogenes (Lm) is a neuroinvasive bacterial pathogen and commonly used model organism for studying immune r
Externí odkaz:
https://doaj.org/article/3fe99d3a64dc419babc6d095e10b4edc
Autor:
Eileen E. Parks, Sreemathi Logan, Alexander Yeganeh, Julie A. Farley, Daniel B. Owen, William E. Sonntag
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 10, Pp 1308-1319 (2020)
Cognitive decline with age is a harmful process that can reduce quality of life. Multiple factors have been established to contribute to cognitive decline, but the overall etiology remains unknown. Here, we hypothesized that cognitive dysfunction is
Externí odkaz:
https://doaj.org/article/e5df94427c3140f2a9e8270d27dd22ab
Autor:
Sreemathi Logan, Gavin A. Pharaoh, M. Caleb Marlin, Dustin R. Masser, Satoshi Matsuzaki, Benjamin Wronowski, Alexander Yeganeh, Eileen E. Parks, Pavithra Premkumar, Julie A. Farley, Daniel B. Owen, Kenneth M. Humphries, Michael Kinter, Willard M. Freeman, Luke I. Szweda, Holly Van Remmen, William E. Sonntag
Publikováno v:
Molecular Metabolism, Vol 9, Iss , Pp 141-155 (2018)
Objective: A decline in mitochondrial function and biogenesis as well as increased reactive oxygen species (ROS) are important determinants of aging. With advancing age, there is a concomitant reduction in circulating levels of insulin-like growth fa
Externí odkaz:
https://doaj.org/article/32814f5809cb49c2965d978f0cb0172f
Autor:
Heather D. VanGuilder, Julie A. Farley, Han Yan, Colleen A. Van Kirk, Matthew Mitschelen, William E. Sonntag, Willard M. Freeman
Publikováno v:
Neurobiology of Disease, Vol 43, Iss 1, Pp 201-212 (2011)
Age-related cognitive decline occurs without frank neurodegeneration and is the most common cause of memory impairment in aging individuals. With increasing longevity, cognitive deficits, especially in hippocampus-dependent memory processes, are incr
Externí odkaz:
https://doaj.org/article/1167c0ebb88a4dd7b5bb1f5723e095d0
Autor:
William E. Sonntag, Eileen E. Parks, Daniel Owen, Sreemathi Logan, Julie A. Farley, Alexander Yeganeh
Publikováno v:
Journal of Lipid Research
Journal of Lipid Research, Vol 61, Iss 10, Pp 1308-1319 (2020)
Journal of Lipid Research, Vol 61, Iss 10, Pp 1308-1319 (2020)
Cognitive decline with age is a harmful process that can reduce quality of life. Multiple factors have been established to contribute to cognitive decline, but the overall etiology remains unknown. Here, we hypothesized that cognitive dysfunction is
Autor:
Sathyaseelan S. Deepa, Daniel Owen, Gordon H. Royce, Michelle Ranjo-Bishop, Sreemathi Logan, William E. Sonntag, Julie A. Farley
Publikováno v:
GeroScience. 41:591-607
Mice deficient in the antioxidant enzyme Cu/Zn-superoxide dismutase (Sod1KO mice) have a significant reduction in lifespan, exhibit many phenotypes of accelerated aging, and have high levels of oxidative stress in various tissues. Age-associated cogn
Autor:
Daniel B Owens, Nicole M. Ashpole, Jessica P. Marshall, William E. Sonntag, Julie A. Farley, Erik L. Hodges, Sreemathi Logan, Cellas A. Hayes
Reductions in insulin-like growth factor-1 (IGF-1) are associated with cognitive impairment and increased risk of neurodegenerative disease in advanced age. In mouse models, reduced IGF-1 early-in-life leads to memory impairments and synaptic dysfunc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fcb3a61a40311929f26d180da3da3311
https://doi.org/10.1101/2021.08.08.455596
https://doi.org/10.1101/2021.08.08.455596
Autor:
Bastijn Koopmans, Anna Csiszar, Amanda L. Sharpe, Julie A. Farley, Arlan Richardson, Maarten Loos, Wei-Jen Chen, Sreemathi Logan, Sixia Chen, William E. Sonntag, Daniel Owen, Zoltan Ungvari
Publikováno v:
GeroScience. 40:123-137
Cognitive function declines substantially with age in both humans and animal models. In humans, this decline is associated with decreases in independence and quality of life. Although the methodology for analysis of cognitive function in human models
Autor:
Holly Van Remmen, Alexander Yeganeh, Luke I. Szweda, Gavin Pharaoh, Daniel Owen, Satoshi Matsuzaki, Pavithra Premkumar, Eileen E. Parks, Michael Kinter, Benjamin Wronowski, Kenneth M. Humphries, M. Caleb Marlin, Sreemathi Logan, Willard M. Freeman, William E. Sonntag, Dustin R. Masser, Julie A. Farley
Publikováno v:
Molecular Metabolism, Vol 9, Iss, Pp 141-155 (2018)
Molecular Metabolism
Molecular Metabolism
Objective A decline in mitochondrial function and biogenesis as well as increased reactive oxygen species (ROS) are important determinants of aging. With advancing age, there is a concomitant reduction in circulating levels of insulin-like growth fac
Autor:
Matthew Mitschelen, William E. Sonntag, Yuji Ikeno, Julie A. Farley, Han Yan, Jacquelyn C Herron, Erik L. Hodges, Nicole M. Ashpole, Anna Csiszar, Mary Beth Humphrey, Sreemathi Logan, Zoltan Ungvari
Publikováno v:
Journal of Bone and Mineral Research. 31:443-454
Advanced aging is associated with increased risk of bone fracture, especially within the vertebrae, which exhibit significant reductions in trabecular bone structure. Aging is also associated with a reduction in circulating levels of insulin-like gro