Zobrazeno 1 - 10 of 14 pro vyhledávání: '"Julie A. Campain"'
1
Characterization of gene expression changes associated with MNNG, arsenic, or metal mixture treatment in human keratinocytes: application of cDNA microarray technology
Autor: Dong-Soon Bae, Raymond S. H. Yang, William H Hanneman, Julie A. Campain
Publikováno v: Environmental Health Perspectives
The identification of molecular markers related to critical biological processes during carcinogenesis may aid in the evaluation of carcinogenic potentials of chemicals and chemical mixtures. Work from our laboratory demonstrated that a single treatm
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c813ec2f84ba546d2a59e7801ad9357e
https://doi.org/10.1289/ehp.02110s6931
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2
BioMOL: a computer-assisted biological modeling tool for complex chemical mixtures and biological processes at the molecular level
Autor: Gang Hou, Julie A. Campain, Richard J Quann, Linda J. Broadbelt, Michael T. Klein, Monica A. Mazurek, Raymond S. H. Yang, Kai H. Liao, Wei Wei
Publikováno v: Environmental Health Perspectives
A chemical engineering approach for the rigorous construction, solution, and optimization of detailed kinetic models for biological processes is described. This modeling capability addresses the required technical components of detailed kinetic model
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::616532ec39ec7c728eeac8abc72b7661
https://doi.org/10.1289/ehp.02110s61025
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3
Statistical analysis of interactive cytotoxicity in human epidermal keratinocytes following exposure to a mixture of four metals
Autor: Julie A. Campain, Raymond S. H. Yang, Chris Gennings, Dong-Soon Bae, Walter H. Carter
Publikováno v: Journal of Agricultural, Biological, and Environmental Statistics. 7:58-73
Exposure to mixtures of chemicals is an important and relevant environmental issue. Of particular interest is the detection and characterization of departure of biological effects from additivity. Methodology based on the assumption of additivity is
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::51e0c57c911143437160d6c765a2dbee
https://doi.org/10.1198/108571102317475062
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4
Application of biologically based computer modeling to simple or complex mixtures
Autor: Melvin E. Andersen, Julie A. Campain, Michael T. Klein, Brad Reisfeld, Kai H. Liao, Wei Wei, Kenneth F. Reardon, James E. Dennison, Richard J. Quann, Raymond S. H. Yang, Ivan D. Dobrev
Publikováno v: Environmental Health Perspectives
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Scopus-Elsevier
The complexity and the astronomic number of possible chemical mixtures preclude any systematic experimental assessment of toxicology of all potentially troublesome chemical mixtures. Thus, the use of computer modeling and mechanistic toxicology for t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::295ad4dc08358a2b971ce32fae882012
http://europepmc.org/articles/PMC1241278
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5
Toxicological Interactions among Arsenic, Cadmium, Chromium, and Lead in Human Keratinocytes
Autor: Walter H. Carter, Chris Gennings, Julie A. Campain, Raymond S. H. Yang, Dong-Soon Bae
Publikováno v: Toxicological Sciences. 63:132-142
To evaluate health effects of chemical mixtures, such as multiple heavy metals in drinking water, we have been developing efficient and accurate hazard identification strategies. Thus, in this study, we determine the cytotoxicity of arsenic, cadmium,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a197556771484d4a623d4090e62f9377
https://doi.org/10.1093/toxsci/63.1.132
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6
Approaches to developing alternative and predictive toxicology based on PBPK/PD and QSAR modeling
Autor: Henk J. M. Verhaar, Russell S. Thomas, Daniel L. Gustafson, Moiz Mumtaz, Stephen A. Benjamin, Julie A. Campain, Raymond S. H. Yang
Publikováno v: Environmental Health Perspectives
Systematic toxicity testing, using conventional toxicology methodologies, of single chemicals and chemical mixtures is highly impractical because of the immense numbers of chemicals and chemical mixtures involved and the limited scientific resources.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0816dd5c634a16b2bc20268f2bf9b7a2
https://doi.org/10.1289/ehp.98106s61385
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7
Characterization of an unusual mutant of human melanoma cells resistant to anticancer drugs that inhibit topoisomerase II
Autor: Jaulang Hwang, Ira Pastan, Michael M. Gottesman, Raji Padmanabhan, Julie A. Campain
Publikováno v: Journal of Cellular Physiology. 155:414-425
The topoisomerase II inhibitor, VP-16 (etoposide), is an important component in many chemotherapeutic regimens. To cahracterize resistance to this drug, the human melanoma cell line, FEM-X, was selected in multiple steps with VP-16. To prevent the de
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b029e175090b0fe0aff2a9aa30d7fbaa
https://doi.org/10.1002/jcp.1041550224
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10
Chemical mixture toxicology: from descriptive to mechanistic, and going on to in silico toxicology
Autor: Ivan D. Dobrev, Kai H. Liao, Melvin E. Andersen, Dong-Soon Bae, James E. Dennison, Russell S. Thomas, Brad Reisfeld, Hisham A. El-Masri, Moiz Mumtaz, Raymond S. H. Yang, Julie A. Campain
Publikováno v: Environmental toxicology and pharmacology. 18(2)
Because of the pioneering vision of certain leaders in the biomedical field, the last two decades witnessed rapid advances in the area of chemical mixture toxicology. Earlier studies utilized conventional toxicology protocol and methods, and they wer
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc790d92a08003b4300a33c26c935143
https://pubmed.ncbi.nlm.nih.gov/21782736
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