Výsledky vyhledávání - "Julie A Vendrell"

Akademický článek

Comparative Methods to Improve the Detection of BRAF V600 Mutations in Highly Pigmented Melanoma Specimens.

Autor: Eric Frouin, Thierry Maudelonde, Romain Senal, Marion Larrieux, Valérie Costes, Sylvain Godreuil, Julie A Vendrell, Jérôme Solassol

Publikováno v: PLoS ONE, Vol 11, Iss 7, p e0158698 (2016)

Genotyping BRAF in melanoma samples is often challenging. The presence of melanin greatly interferes with thermostable DNA polymerases and/or nucleic acids in traditional polymerase chain reaction (PCR)-based methods. In the present work, we evaluate

Externí odkaz: https://doaj.org/article/58b4574270db4489a39780360ccaf88f

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Akademický článek

A Bioinformatics Toolkit for Next-Generation Sequencing in Clinical Oncology

Autor: Simon Cabello-Aguilar, Julie A. Vendrell, Jérôme Solassol

Publikováno v: Current Issues in Molecular Biology, Vol 45, Iss 12, Pp 9737-9752 (2023)

Next-generation sequencing (NGS) has taken on major importance in clinical oncology practice. With the advent of targeted therapies capable of effectively targeting specific genomic alterations in cancer patients, the development of bioinformatics pr

Externí odkaz: https://doaj.org/article/6f620beb82b34454a4853126c4c23f45

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Akademický článek

Characterizing PALB2 intragenic duplication breakpoints in a triple-negative breast cancer case using long-read sequencing

Autor: Iulian O. Ban, Alice Chabert, Thomas Guignard, Jacques Puechberty, Simon Cabello-Aguilar, Pascal Pujol, Julie A. Vendrell, Jérôme Solassol

Publikováno v: Frontiers in Oncology, Vol 14 (2024)

IntroductionAccurate identification and characterization of Large Genomic Rearrangements (LGR), especially duplications, are crucial for precise diagnosis and risk assessment. In this report, we characterized an intragenic duplication breakpoint of P

Externí odkaz: https://doaj.org/article/476bc9d5b9164fcab4492b6136f55df5

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Akademický článek

ifCNV: A novel isolation-forest-based package to detect copy-number variations from various targeted NGS datasets

Autor: Simon Cabello-Aguilar, Julie A. Vendrell, Charles Van Goethem, Mehdi Brousse, Catherine Gozé, Laurent Frantz, Jérôme Solassol

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 30, Iss , Pp 174-183 (2022)

Copy-number variations (CNVs) are an essential component of genetic variation distributed across large parts of the human genome. CNV detection from next-generation sequencing data and artificial intelligence algorithms have progressed in recent year

Externí odkaz: https://doaj.org/article/d38e06b160a4414382a8f7062ccdc4db

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Akademický článek

Case report: Liquid biopsy, the sooner the better?

Autor: Quentin Dominique Thomas, Julien Colard-Thomas, Delphine Delansay, Fanny Leenhardt, Jerome Solassol, Julie A. Vendrell, Xavier Quantin

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

The detection of circulating tumor DNA (ctDNA) by liquid biopsy is taking an increasing role in thoracic oncology management due to its predictive and prognostic value. For non-small cell lung cancer, it allows the detection of molecular mutations th

Externí odkaz: https://doaj.org/article/c4256822ac1d4b32936effa6be87ef77

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Akademický článek

Combination of tissue and liquid biopsy molecular profiling to detect transformation to small cell lung carcinoma during osimertinib treatment

Autor: Julie A. Vendrell, Xavier Quantin, Isabelle Serre, Jérôme Solassol

Publikováno v: Therapeutic Advances in Medical Oncology, Vol 12 (2020)

Background: Histological transformation of advanced non-small cell lung cancer (NSCLC) to small cell lung cancer (SCLC) is one of the mechanisms of resistance to third-generation tyrosine kinase inhibitors (TKIs), such as osimertinib. This acquired T

Externí odkaz: https://doaj.org/article/8cc493f73bd94b3497491fbd3dc9ae09

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