Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Julie A K, McDonald"'
Autor:
Jack W. Rutter, Linda Dekker, Chania Clare, Zoe F. Slendebroek, Kimberley A. Owen, Julie A. K. McDonald, Sean P. Nair, Alex J. H. Fedorec, Chris P. Barnes
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Bacteriocins are antimicrobial peptides that are naturally produced by many bacteria. They hold great potential in the fight against antibiotic resistant bacteria, including ESKAPE pathogens. Engineered live biotherapeutic products (eLBPs) t
Externí odkaz:
https://doaj.org/article/8ca6366764d747bfa545638bbe0e2cfe
Autor:
Alexander Y. G. Yip, Olivia G. King, Oleksii Omelchenko, Sanjana Kurkimat, Victoria Horrocks, Phoebe Mostyn, Nathan Danckert, Rohma Ghani, Giovanni Satta, Elita Jauneikaite, Frances J. Davies, Thomas B. Clarke, Benjamin H. Mullish, Julian R. Marchesi, Julie A. K. McDonald
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract The intestine is the primary colonisation site for carbapenem-resistant Enterobacteriaceae (CRE) and serves as a reservoir of CRE that cause invasive infections (e.g. bloodstream infections). Broad-spectrum antibiotics disrupt colonisation r
Externí odkaz:
https://doaj.org/article/dfbcc9d5a51c4088979906aa338bfd0e
Autor:
James L. Alexander, Joram M. Posma, Alasdair Scott, Liam Poynter, Sam E. Mason, M. Luisa Doria, Lili Herendi, Lauren Roberts, Julie A. K. McDonald, Simon Cameron, David J. Hughes, Vaclav Liska, Simona Susova, Pavel Soucek, Verena Horneffer-van der Sluis, Maria Gomez-Romero, Matthew R. Lewis, Lesley Hoyles, Andrew Woolston, David Cunningham, Ara Darzi, Marco Gerlinger, Robert Goldin, Zoltan Takats, Julian R. Marchesi, Julian Teare, James Kinross
Publikováno v:
Microbiome, Vol 11, Iss 1, Pp 1-14 (2023)
Abstract Background and aims The gut microbiota is implicated in the pathogenesis of colorectal cancer (CRC). We aimed to map the CRC mucosal microbiota and metabolome and define the influence of the tumoral microbiota on oncological outcomes. Method
Externí odkaz:
https://doaj.org/article/12e07005f08c4eff961ce1c2bc1eb63e
Autor:
Sam T. R. Powles, Kate I. Gallagher, Leo W. L. Chong, James L. Alexander, Benjamin H. Mullish, Lucy C. Hicks, Julie A. K. McDonald, Julian R. Marchesi, Horace R. T. Williams, Timothy R. Orchard
Publikováno v:
BMC Gastroenterology, Vol 22, Iss 1, Pp 1-9 (2022)
Abstract Background Urinary and faecal metabolic profiling have been extensively studied in gastrointestinal diseases as potential diagnostic markers, and to enhance our understanding of the intestinal microbiome in the pathogenesis these conditions.
Externí odkaz:
https://doaj.org/article/bd479af395644bdb902270d2ec762c46
Autor:
Pamela Pruski, Gonçalo D. S. Correia, Holly V. Lewis, Katia Capuccini, Paolo Inglese, Denise Chan, Richard G. Brown, Lindsay Kindinger, Yun S. Lee, Ann Smith, Julian Marchesi, Julie A. K. McDonald, Simon Cameron, Kate Alexander-Hardiman, Anna L. David, Sarah J. Stock, Jane E. Norman, Vasso Terzidou, T. G. Teoh, Lynne Sykes, Phillip R. Bennett, Zoltan Takats, David A. MacIntyre
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Here, the authors apply DESI-MS, a sample preparation-free, direct on-swab mass spectrometry analytical tool, to profile the cervicovaginal metabolome of two independent cohorts of pregnant women and, combined with matched metataxonomic and immuno-pr
Externí odkaz:
https://doaj.org/article/679b2cee8c274823b08f0652136477bc
Autor:
Thomas S. Webberley, Giulia Masetti, Ryan J. Bevan, Joshua Kerry-Smith, Alison A. Jack, Daryn R. Michael, Sophie Thomas, Maria Glymenaki, Jia Li, Julie A. K. McDonald, Daniel John, James E. Morgan, Julian R. Marchesi, Mark A. Good, Sue F. Plummer, Timothy R. Hughes
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Brain degenerative disorders such as Alzheimer’s disease (AD) can be exacerbated by aberrant metabolism. Supplementation with probiotic bacteria is emerging as a promising preventative strategy for both neurodegeneration and metabolic syndrome. In
Externí odkaz:
https://doaj.org/article/77eda7a758794348b5e35fc83931f5f5
Autor:
Natalie S. Shenker, Alvaro Perdones-Montero, Adam Burke, Sarah Stickland, Julie A. K. McDonald, Simon J. S. Cameron
Publikováno v:
Metabolites, Vol 12, Iss 11, p 1069 (2022)
Given the long-term advantages of exclusive breastfeeding to infants and their mothers, there is both an individual and public health benefit to its promotion and support. Data on the composition of human milk over the course of a full period of lact
Externí odkaz:
https://doaj.org/article/9423c738c1b547bbb78646dcd8daafd1
Autor:
Andrew J. Innes, Benjamin H. Mullish, Rohma Ghani, Richard M. Szydlo, Jane F. Apperley, Eduardo Olavarria, Renuka Palanicawandar, Edward J. Kanfer, Dragana Milojkovic, Julie A. K. McDonald, Eimear T. Brannigan, Mark R. Thursz, Horace R. T. Williams, Frances J. Davies, Julian R. Marchesi, Jiří Pavlů
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
The gut microbiome can be adversely affected by chemotherapy and antibiotics prior to hematopoietic cell transplantation (HCT). This affects graft success and increases susceptibility to multidrug-resistant organism (MDRO) colonization and infection.
Externí odkaz:
https://doaj.org/article/4dcfa51077a541a48d2953a33496bb14
Autor:
Zhigang Liu, Isabelle Coales, Nicholas Penney, Julie A. K. McDonald, Jutarop Phetcharaburanin, Florian Seyfried, Jia V. Li
Publikováno v:
mSystems, Vol 5, Iss 6 (2020)
ABSTRACT Roux-en-Y gastric bypass (RYGB) is an effective weight loss surgery, resulting in a characteristic increase of fecal Gammaproteobacteria. The contribution of this compositional change to metabolic benefits of RYGB is currently debatable. The
Externí odkaz:
https://doaj.org/article/02c1e006a9a04f28bff0656a1aa7b9c5
Autor:
Laura Martinez-Gili, Julie a K McDonald, Zhigang Liu, Dina Kao, Jessica R Allegretti, Tanya M Monaghan, Grace F Barker, Jesús Miguéns Blanco, Horace R T Williams, Elaine Holmes, Mark R Thursz, Julian R Marchesi, Benjamin H Mullish
Publikováno v:
Gut Microbes, Vol 12, Iss 1 (2020)
Fecal microbiota transplant (FMT) is a highly-effective therapy for recurrent Clostridioides difficile infection (rCDI), and shows promise for certain non-CDI indications. However, at present, its mechanisms of efficacy have remained poorly understoo
Externí odkaz:
https://doaj.org/article/3f6ec94a2aec4415a86b8766d126f15a