Zobrazeno 1 - 10
of 312
pro vyhledávání: '"Julie A Blendy"'
Autor:
Gregory J. Salimando, Sébastien Tremblay, Blake A. Kimmey, Jia Li, Sophie A. Rogers, Jessica A. Wojick, Nora M. McCall, Lisa M. Wooldridge, Amrith Rodrigues, Tito Borner, Kristin L. Gardiner, Selwyn S. Jayakar, Ilyas Singeç, Clifford J. Woolf, Matthew R. Hayes, Bart C. De Jonghe, F. Christian Bennett, Mariko L. Bennett, Julie A. Blendy, Michael L. Platt, Kate Townsend Creasy, William R. Renthal, Charu Ramakrishnan, Karl Deisseroth, Gregory Corder
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-24 (2023)
Abstract With concurrent global epidemics of chronic pain and opioid use disorders, there is a critical need to identify, target and manipulate specific cell populations expressing the mu-opioid receptor (MOR). However, available tools and transgenic
Externí odkaz:
https://doaj.org/article/a8640e5f569f44e78d30da18c1b04162
Autor:
Darrell Eacret, Elisabetta Manduchi, Julia Noreck, Emma Tyner, Polina Fenik, Amelia D. Dunn, Jonathan Schug, Sigrid C. Veasey, Julie A. Blendy
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Disrupted sleep is a symptom of many psychiatric disorders, including substance use disorders. Most drugs of abuse, including opioids, disrupt sleep. However, the extent and consequence of opioid-induced sleep disturbance, especially during
Externí odkaz:
https://doaj.org/article/46e6f3cd581c4b7d935a19695d273593
Autor:
Amelia D. Dunn, Shivon A. Robinson, Chiso Nwokafor, Molly Estill, Julia Ferrante, Li Shen, Crystal O. Lemchi, Jordi Creus-Muncunill, Angie Ramirez, Juliet Mengaziol, Julia K. Brynildsen, Mark Leggas, Jamie Horn, Michelle E. Ehrlich, Julie A. Blendy
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 17 (2023)
IntroductionInfants exposed to opioids in utero are at high risk of exhibiting Neonatal Opioid Withdrawal Syndrome (NOWS), a combination of somatic withdrawal symptoms including high pitched crying, sleeplessness, irritability, gastrointestinal distr
Externí odkaz:
https://doaj.org/article/5c02e79f5cd44978b1bd5dd7551f72ee
Autor:
Kaori Kawakami, Tomomitsu Miyasaka, Yutaka Nakamura, Hirohito Metoki, Satoshi Miyata, Miki Sato, Ichiro Sora, Kohei Yamauchi, Kazuyoshi Kawakami, Julie A. Blendy, Tasuku Kawano, Hiroaki Shimokawa, Motoaki Takayanagi, Isao Ohno, Tomoko Takahashi
Publikováno v:
Allergology International, Vol 71, Iss 1, Pp 55-65 (2022)
Background: Although population studies have implicated emotional burden in asthma severity, the underlying genetic risk factors are not completely understood. We aimed to evaluate the genetic influence of a functional single-nucleotide polymorphism
Externí odkaz:
https://doaj.org/article/50b5c152571a44338ba2914601cc70e4
Autor:
Deborah Y. Kwon, Bing Xu, Peng Hu, Ying-Tao Zhao, Jonathan A. Beagan, Jonathan H. Nofziger, Yue Cui, Jennifer E. Phillips-Cremins, Julie A. Blendy, Hao Wu, Zhaolan Zhou
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
The mechanisms underlying the chronic stress-induced increased risk for major depressive disorder and anxiety are unclear. Here, the authors show the transcriptional changes occurring in neocortical neurons and identify YY1 as a regulator of chronic
Externí odkaz:
https://doaj.org/article/a4ebaaa7bd0e4a8ca9b257ee066c81e7
Autor:
Darrell Eacret, Crystal Lemchi, Jasmine I. Caulfield, Sonia A. Cavigelli, Sigrid C. Veasey, Julie A. Blendy
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
The opioid epidemic remains a significant healthcare problem and is attributable to over 100,000 deaths per year. Poor sleep increases sensitivity to pain, impulsivity, inattention, and negative affect, all of which might perpetuate drug use. Opioid
Externí odkaz:
https://doaj.org/article/ac641bf2dd074a5ea14d0e2acbdf9a74
Autor:
Juliet Mengaziol, Amelia D Dunn, Gregory Salimando, Lisa Wooldridge, Jordi Crues-Muncunill, Darrell Eacret, Chongguang Chen, Kathryn Bland, Lee-Yuan Liu-Chen, Michelle E Ehrlich, Gregory Corder, Julie A Blendy
Publikováno v:
PLoS ONE, Vol 17, Iss 12, p e0270317 (2022)
Key targets of both the therapeutic and abused properties of opioids are μ-opioid receptors (MORs). Despite years of research investigating the biochemistry and signal transduction pathways associated with MOR activation, we do not fully understand
Externí odkaz:
https://doaj.org/article/466f545ecc3444c2ab07f20e19c44050
Autor:
Lynette A. Desouza, Madhurima Benekareddy, Sashaina E. Fanibunda, Farhan Mohammad, Balaganesh Janakiraman, Utkarsha Ghai, Tamar Gur, Julie A. Blendy, Vidita A. Vaidya
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Psychedelic compounds that target the 5-HT2A receptor are reported to evoke psychoplastogenic effects, including enhanced dendritic arborization and synaptogenesis. Transcriptional regulation of neuronal plasticity-associated genes is implicated in t
Externí odkaz:
https://doaj.org/article/d8b628bfb60b400eb9db314691858edb
Deficits in working memory (WM) are observable in a wide range of those psychiatric disorders associated with decreased activation of the prefrontal cortex. Given that WM is a crucial process supporting various cognitive functions, deficits interfere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad37110ee64f5ff6f64773b382f3c2a7
https://doi.org/10.21203/rs.3.rs-2894479/v1
https://doi.org/10.21203/rs.3.rs-2894479/v1
Autor:
Carmen Weidler, Ute Habel, Philippa Hüpen, Dilsa Akkoc, Frank Schneider, Julie A. Blendy, Lisa Wagels
Publikováno v:
Frontiers in Psychiatry, Vol 10 (2019)
As many paths lead to aggression, understanding which situations and which person-specific traits facilitate or impede aggressive behavior is crucial. Provocation is among one of the most frequently reported predictors of aggressive behavior. However
Externí odkaz:
https://doaj.org/article/7649dfac6fbc46e6832635da8528e1fe