Two essential Thioredoxins mediate apicoplast biogenesis, protein import, and gene expression in Toxoplasma gondii.

Autor: Marco Biddau, Anne Bouchut, Jack Major, Tracy Saveria, Julie Tottey, Ojore Oka, Marcel van-Lith, Katherine Elizabeth Jennings, Jana Ovciarikova, Amy DeRocher, Boris Striepen, Ross Frederick Waller, Marilyn Parsons, Lilach Sheiner

Publikováno v: PLoS Pathogens, Vol 14, Iss 2, p e1006836 (2018)

Apicomplexan parasites are global killers, being the causative agents of diseases like toxoplasmosis and malaria. These parasites are known to be hypersensitive to redox imbalance, yet little is understood about the cellular roles of their various re

Externí odkaz: https://doaj.org/article/971e47a9d0744ad6bcce81deef63eef6

In silico screen identifies a new Toxoplasma gondii mitochondrial ribosomal protein essential for mitochondrial translation

Autor: Jana Ovciarikova, Julie Tottey, Andrew E Maclean, Alice Lacombe, Lilach Sheiner

SummaryApicomplexan parasites cause diseases such as malaria and toxoplasmosis. The apicomplexan mitochondrion shows striking differences from common model organisms, including in fundamental processes such as mitochondrial translation. Despite evide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c2593bdb6b13c586fdbf910e8796129
https://doi.org/10.1101/543520

Metal-captured inhibition of pre-mRNA processing activity by CPSF3 controls Cryptosporidium infection

Autor: Alexandre Bougdour, Christopher Swale, Andrés Palencia, Audrey Gnahoui-David, Fabrice Laurent, Mohamed-Ali Hakimi, Sonia Georgeault, Julie Tottey

Publikováno v: Science Translational Medicine
Science Translational Medicine, American Association for the Advancement of Science, 2019, 11 (517), ⟨10.1126/scitranslmed.aax7161⟩
Sci Transl Med
Sci Transl Med, 2019, 11 (517), 11 p. ⟨10.1126/scitranslmed.aax7161⟩
Sci Transl Med, 2019, 11 (517), pii: eaax7161. ⟨10.1126/scitranslmed.aax7161⟩

International audience; Cryptosporidium is an intestinal pathogen that causes severe but self-limiting diarrhea in healthy humans, yet it can turn into a life-threatening, unrelenting infection in immunocompromised patients and young children. Severe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab80f80f69f4419468c411515a8dbbc0
https://hal.archives-ouvertes.fr/hal-02437596

Identification of the Toxoplasma gondii mitochondrial ribosome, and characterisation of a protein essential for mitochondrial translation

Autor: Lilach Sheiner, Jana Ovciarikova, Andrew E Maclean, Alice Lacombe, Paula Fernandes, Alexander Mühleip, Julie Tottey

Publikováno v: Molecular Microbiology
Molecular Microbiology, Wiley, 2019, 112 (4), pp.1235-1252. ⟨10.1111/mmi.14357⟩
Molecular Microbiology, . (2019)

Summary Apicomplexan parasites cause diseases such as malaria and toxoplasmosis. The apicomplexan mitochondrion shows striking differences from common model organisms, including fundamental processes such as mitochondrial translation. Despite evidenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b98600318d6691ebd077ddd862be960
https://hal.inrae.fr/hal-02622440

Current knowledge and toward new promising therapies to control cryptosporidiosis

Autor: Fabrice Laurent, Gergo Motan, Moodie, Lindon W. K., Caroline Theresine, Tiffany Pézier, Julie TOTTEY, Sonia Lacroix-Lamandé, Céline Barc, Christian Hedberg

Publikováno v: HAL
13. European Multi¬colloquium of Parasitology (EMOP 2021)
13. European Multi¬colloquium of Parasitology (EMOP 2021), the Serbian Society for Parasitology and the European Federation of Parasitologists (EFP), Oct 2021, Belgrade, Serbia

International audience; Background: Cryptosporidiosis consists in acute gastrointestinal infections in young children and is one of the two main leading causes of diarrhea in newborn calves in France and England resulting in substantial financial los

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::33edee2a7b0bc865cf3b648090424e40
https://hal.archives-ouvertes.fr/hal-03470811