Enhancing [177Lu]Lu-DOTA-TATE therapeutic efficacy in vitro by combining it with metronomic chemotherapeutics

Autor: Jordan Cheng, Joke Zink, Edward O’Neill, Bart Cornelissen, Julie Nonnekens, Lefteris Livieratos, Samantha Y. A. Terry

Publikováno v: EJNMMI Research, Vol 14, Iss 1, Pp 1-11 (2024)

Abstract Background Peptide receptor radionuclide therapy (PRRT) uses [177Lu]Lu-[DOTA0-Tyr3]octreotate ([177Lu]Lu-DOTA-TATE) to treat patients with neuroendocrine tumours (NETs) overexpressing the somatostatin receptor 2A (SSTR2A). It has shown signi

Externí odkaz: https://doaj.org/article/c2dfe895678c431e9e12583837aa8980

Radiolabeling and quality control of therapeutic radiopharmaceuticals: optimization, clinical implementation and comparison of radio-TLC/HPLC analysis, demonstrated by [177Lu]Lu-PSMA

Autor: Eline L. Hooijman, Carolline M. Ntihabose, Thom G. A. Reuvers, Julie Nonnekens, Else A. Aalbersberg, Jordy R. J. P. van de Merbel, Judith E. Huijmans, Stijn L. W. Koolen, Jeroen J. M. A. Hendrikx, Erik de Blois

Publikováno v: EJNMMI Radiopharmacy and Chemistry, Vol 7, Iss 1, Pp 1-13 (2022)

Abstract Background Radiopharmaceuticals are considered as regular medicinal products and therefore the same regulations as for non-radioactive medicinal products apply. However, specific aspects should be considered due to the radiochemical properti

Externí odkaz: https://doaj.org/article/8919aeb2fb114174a30cb978b48e3a49

Cellular dosimetry of [177Lu]Lu-DOTA-[Tyr3]octreotate radionuclide therapy: the impact of modeling assumptions on the correlation with in vitro cytotoxicity

Autor: Giulia Tamborino, Marijke De Saint-Hubert, Lara Struelens, Dayana C. Seoane, Eline A. M. Ruigrok, An Aerts, Wiggert A. van Cappellen, Marion de Jong, Mark W. Konijnenberg, Julie Nonnekens

Publikováno v: EJNMMI Physics, Vol 7, Iss 1, Pp 1-19 (2020)

Abstract Background Survival and linear-quadratic model fitting parameters implemented in treatment planning for targeted radionuclide therapy depend on accurate cellular dosimetry. Therefore, we have built a refined cellular dosimetry model for [177

Externí odkaz: https://doaj.org/article/3f518fc5abf94785bb169b9564a1b55f

In vitro dose effect relationships of actinium-225- and lutetium-177-labeled PSMA-I&T

Autor: Eline A. M. Ruigrok, Giulia Tamborino, Erik de Blois, Stefan J. Roobol, Nicole Verkaik, Marijke De Saint-Hubert, Mark W. Konijnenberg, Wytske M. van Weerden, Marion de Jong, Julie Nonnekens

Publikováno v: European Journal of Nuclear Medicine and Molecular Imaging, 49(11), 3627-3638. Springer-Verlag

Purpose Targeting the prostate-specific membrane antigen (PSMA) using lutetium-177-labeled PSMA-specific tracers has become a very promising novel therapy option for prostate cancer (PCa). The efficacy of this therapy might be further improved by rep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f6aab3e97e18b25009e210e17a20b66
http://www.scopus.com/inward/record.url?scp=85129823500&partnerID=8YFLogxK

Dosimetric Evaluation of the Effect of Receptor Heterogeneity on the Therapeutic Efficacy of Peptide Receptor Radionuclide Therapy

Autor: Mark Konijnenberg, Giulia Tamborino, Marijke De Saint-Hubert, Marion de Jong, Julie Nonnekens, Lara Struelens, Danny Feijtel

Publikováno v: Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 63(1), 100-107. Society of Nuclear Medicine and Molecular Imaging

Our rationale was to build a refined dosimetry model for 177Lu- DOTATATE in vivo experiments enabling the correlation of absorbed dose with double-strand break (DSB) induction and cell death. Methods: Somatostatin receptor type 2 expression of NCI-H6

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bc925e98ab54e9c60d6a2e216e51c28
https://doi.org/10.2967/jnumed.121.262122