Výsledky vyhledávání - "Julie, Depuydt"

Decreased DNA double‑strand break repair and enhanced chromosomal radiosensitivity in irradiated non‑tumorigenic human breast epithelial cells with a partial BRCA1 or BRCA2 knockdown

Autor: Jeroen Vierstraete, Mattias Van Heetvelde, Julie Depuydt, Maria Federica Palermo, Jan Philippé, Gianpaolo Perletti, Annelot Baert, Bram Verstraete, Anne Vral, Anna Sablina, Kathleen Claes

Publikováno v: WORLD ACADEMY OF SCIENCES JOURNAL

It has previously been demonstrated that peripheral blood lymphocytes of healthy women carrying BRCA1 or BRCA2 mutations exhibit increased chromosomal radiosensitivity, which is characterized by an enhanced formation of micronuclei. These results sug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::004e9ba324fa3578472ecc33bdc6dc6c
https://doi.org/10.3892/wasj.2020.35

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A semi-automated FISH-based micronucleus-centromere assay for biomonitoring of hospital workers exposed to low doses of ionizing radiation

Autor: Veerle Decorte, Julie Depuydt, André Wambersie, Anne Vral, Hubert Thierens

Publikováno v: Molecular Medicine Reports
MOLECULAR MEDICINE REPORTS
Molecular Medicine Reports, Vol. 14, no.1, p. 103-110 (2016)

The aim of the present study was to perform cytogenetic analysis by means of a semi-automated micro-nucleus-centromere assay in lymphocytes from medical radiation workers. Two groups of workers receiving the highest occupational doses were selected:

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bf6fe3385bfc050bc106702694692a1
http://europepmc.org/articles/PMC4918626

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DNA double strand breaks induced by low dose mammography X‑rays in breast tissue: A pilot study

Autor: Tanguy Viaene, Anne Vral, Hubert Thierens, Phillip Blondeel, Julie Depuydt, Nathalie Roche, Rudy Van den Broecke

Publikováno v: Oncology Letters.

Breast tissue is very sensitive to ionizing radiation due to the presence of reproductive hormones, including estrogen. In the present pilot study, the efficiency of mammography X-rays to induce DNA double strand breaks (DSB) in mammary epithelial ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::919c52e26bc1f812fd6befc45d22ce90
https://doi.org/10.3892/ol.2018.9024

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Analysis of chromosomal radiosensitivity of healthy BRCA2 mutation carriers and non-carriers in BRCA families with the G2 micronucleus assay

Autor: Fransiska Malfait, Tim Van Damme, Anne Vral, Bruce Poppe, Gianpaolo Perletti, Annelot Baert, Tom Van Maerken, Julie Depuydt, Sylvia De Nobele, Kim De Leeneer, Kathleen Claes

Publikováno v: ONCOLOGY REPORTS
Oncology Reports

Breast cancer risk drastically increases in individuals with a heterozygous germline BRCA1 or BRCA2 mutation, while it is estimated to equal the population risk for relatives without the familial mutation (non-carriers). The aim of the present study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a69090e56b1bc7df18697eaab3ed20f
https://biblio.ugent.be/publication/8507493

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Induction and disappearance of γH2AX foci and formation of micronuclei after exposure of human lymphocytes to60Co γ-rays and p(66)+ Be(40) neutrons

Autor: Julie Depuydt, Anne Vral, Bram Van Bockstaele, Jacobus Slabbert, Philip Beukes, Veerle Vandersickel

Publikováno v: International Journal of Radiation Biology. 90:149-158

Purpose: To investigate both the formation of micronuclei (MN) and the induction and subsequent loss of phosphorylated histone H2AX foci (γH2AX foci) after in vitro exposure of human lymphocytes to either 60Co γ-rays or p(66)+ Be(40) neutrons.Mater

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::76d16d7405af49e2efcd2cef5df620ab
https://doi.org/10.3109/09553002.2014.860252

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Variant Ataxia Telangiectasia: Clinical and Molecular Findings and Evaluation of Radiosensitive Phenotypes in a Patient and Relatives

Autor: Julie Depuydt, A. Malcolm R. Taylor, Kim De Leeneer, Marc D’Hooghe, Peter Schietecatte, Veerle Vandersickel, Kathleen Claes, Bruce Poppe, Anne Vral, Annelot Baert

Publikováno v: NeuroMolecular Medicine. 15:447-457

Variant ataxia telangiectasia (A-T) may be an underdiagnosed entity. We correlate data from radiosensitivity and kinase assays with clinical and molecular data from a patient with variant A-T and relatives. The coding region of ATM was sequenced. To

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39da54e13d56322df0d993df775163ed
https://doi.org/10.1007/s12017-013-8231-4

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Increased chromosomal radiosensitivity in asymptomatic carriers of a heterozygous BRCA1 mutation

Autor: Annelot Baert, Tom Van Maerken, Anne Vral, Fransiska Malfait, Julie Depuydt, Bruce Poppe, Kathleen Claes, Sylvia De Nobele, Katrien Storm, Gianpaolo Perletti, Tim Van Damme, Kim De Leeneer, Jenneke van den Ende

Publikováno v: BREAST CANCER RESEARCH
Breast Cancer Research : BCR
Breast cancer research

Background Breast cancer risk increases drastically in individuals carrying a germline BRCA1 mutation. The exposure to ionizing radiation for diagnostic or therapeutic purposes of BRCA1 mutation carriers is counterintuitive, since BRCA1 is active in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ecbc9d8d0568b5650a409072f36ee95
http://hdl.handle.net/11383/2042342

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O44. The differences in induction and repair of DNA DSB induced by 30 kV X-rays, fast neutrons and γ-rays

Autor: Julie Depuydt, Anne Vral, Veerle Vandersickel, Jacobus Slabbert, Annelot Baert, Hubert Thierens, P. Beukes

Publikováno v: Physica Medica. 32:155-156

Introduction Radiation is known to be an inducer of cancer, however, radiation is also often used in a useful manner in radiotherapy and diagnostic imaging. In this research, we investigated the efficiency of different radiation qualities to induce D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ec6d2b13279acf07d49336661de86ae4
https://doi.org/10.1016/j.ejmp.2016.07.052

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O39. In vitro cellular radiosensitivity assays as predictor of radiotherapy related late toxicity in breast cancer patients

Autor: Charlot Vandevoorde, Anne Vral, Annelot Baert, W. De Neve, S. De Langhe, Jan Philippé, Julie Depuydt, Liv Veldeman, Greet Wieme, Natividad Sebastià, Hubert Thierens

Publikováno v: Physica Medica. 32:153-154

Introduction About 5% of cancer patients receiving radiation therapy (RT) exhibit severe normal tissue reactions. The prediction of late toxicity in cancer patients would enable individualized and optimized radiation dose prescription. In this study,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2871bf01b0697e51dc7637ec67b4c38c
https://doi.org/10.1016/j.ejmp.2016.07.047

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