Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Julie, Chan"'
Autor:
Piers Patten, Paul Buckley, Julie Chan, Laura Jouvin, Cynthia Bishop, Katrina Todd, Elizabeth H. Phillips, Alessia Bottos
Publikováno v:
HemaSphere, Vol 7, p e7107091 (2023)
Externí odkaz:
https://doaj.org/article/0292080d8b3041f593ecae455c8a98e3
Autor:
Robert M. Cox, Josef D. Wolf, Carolin M. Lieber, Julien Sourimant, Michelle J. Lin, Darius Babusis, Venice DuPont, Julie Chan, Kim T. Barrett, Diane Lye, Rao Kalla, Kwon Chun, Richard L. Mackman, Chengjin Ye, Tomas Cihlar, Luis Martinez-Sobrido, Alexander L. Greninger, John P. Bilello, Richard K. Plemper
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Remdesivir is an approved antiviral treatment for COVID-19, but it needs to be administered intravenously. Here, Cox et al. show that GS-621763, a prodrug of remdesivir parent nucleoside GS-441524 has good oral bioavailability and inhibits SARS-CoV-2
Externí odkaz:
https://doaj.org/article/480b9bcf109e47b7bd2093b34d9f4683
Publikováno v:
Revue de Chirurgie Orthopédique et Traumatologique. 109:522-528
Autor:
Matthias Thepaut, Hassene Affes, Sylvain Brochard, Christelle Pons, Julie Chan-Waï-Nam, Camille Printemps, Antoine Josse
Publikováno v:
Revue de Chirurgie Orthopédique et Traumatologique. 109:443-449
Resume Introduction Le transfert du muscle droit femoral (DF) a longtemps ete la reference dans le traitement de la marche en genou raide ou stiff knee gait (SKG). Son efficacite a ete remise en cause au profit de la tenotomie distale du DF. Notre ob
Autor:
Joy Y. Feng, Venice Du Pont, Darius Babusis, Calvin J. Gordon, Egor P. Tchesnokov, Jason K. Perry, Vincent Duong, Arya Vijjapurapu, Xiaofeng Zhao, Julie Chan, Cal Cohen, Kavita Juneja, Tomas Cihlar, Matthias Götte, John P. Bilello
Publikováno v:
Molecules, Vol 27, Iss 13, p 4212 (2022)
The urgent response to the COVID-19 pandemic required accelerated evaluation of many approved drugs as potential antiviral agents against the causative pathogen, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Using cell-based, biochemi
Externí odkaz:
https://doaj.org/article/8efa8d1cc25f4a15b4af0c4caa0f1353
Autor:
Matthew T. Burger, Jocelyn Holash, Richard Zang, J. Alex Aycinena, Cornelia Bellamacina, Mika Lindvall, Gisele Nishiguchi, Jiong Lan, Wooseok Han, Christopher Wilson, Joerg Trappe, Peter Drueckes, Estelle Pfister, Audrey Kauffmann, Christine Fritsch, Tiffany Tsang, Jamie Narberes, Robert Warne, Paul Feucht, Michael Doyle, Jianjun Yu, Julie Chan, Stephen Basham, Xiao-Hong Niu, Jing Lu, Yumin Dai, Tatiana Zavorotinskaya, Marjorie Ison, Christie Fanton, Joseph Castillo, Min Chen, Yingyun Wang, John L. Langowski, Pablo D. Garcia
Purpose: PIM kinases have been shown to act as oncogenes in mice, with each family member being able to drive progression of hematologic cancers. Consistent with this, we found that PIMs are highly expressed in human hematologic cancers and show that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b7a0911566c282b44322df88773977
https://doi.org/10.1158/1078-0432.c.6522398
https://doi.org/10.1158/1078-0432.c.6522398
Autor:
Matthew T. Burger, Jocelyn Holash, Richard Zang, J. Alex Aycinena, Cornelia Bellamacina, Mika Lindvall, Gisele Nishiguchi, Jiong Lan, Wooseok Han, Christopher Wilson, Joerg Trappe, Peter Drueckes, Estelle Pfister, Audrey Kauffmann, Christine Fritsch, Tiffany Tsang, Jamie Narberes, Robert Warne, Paul Feucht, Michael Doyle, Jianjun Yu, Julie Chan, Stephen Basham, Xiao-Hong Niu, Jing Lu, Yumin Dai, Tatiana Zavorotinskaya, Marjorie Ison, Christie Fanton, Joseph Castillo, Min Chen, Yingyun Wang, John L. Langowski, Pablo D. Garcia
PDF file - 346KB, Supplementary Figure 1. Normal vs. Tumor expression of PIM kinases mRNA across 17 tissue types. Supplementary Figure 2. Comparison of LGB321 on-target activity vs. Previously described pan-PIM inhibitor. Supplementary Figure 3. KINO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4cf370c3ede2546f0f7aab800bf1d63
https://doi.org/10.1158/1078-0432.22452158.v1
https://doi.org/10.1158/1078-0432.22452158.v1
Autor:
John P. Bilello, Darius Babusis, Michelle J. Lin, Venice DuPont, Carolin M. Lieber, Kwon Soo Chun, Kim T. Barrett, Chengjin Ye, Robert M. Cox, Rao Kalla, Tomas Cihlar, Diane Lye, Alexander L. Greninger, Josef D. Wolf, Richard L. Mackman, Richard K. Plemper, Julien Sourimant, Luis Martinez-Sobrido, Julie Chan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications
Nature Communications
Remdesivir is an antiviral approved for COVID-19 treatment, but its wider use is limited by intravenous delivery. An orally bioavailable remdesivir analog may boost therapeutic benefit by facilitating early administration to non-hospitalized patients
Autor:
Julie Chan-Waï-Nam, Sylvain Brochard, Christelle Pons, Camille Printemps, Matthias Thepaut, Antoine Josse, Hassene Affes
Publikováno v:
Orthopaedics & Traumatology: Surgery & Research. 109:103022
Introduction Rectus femoris (RF) transfer was long the gold-standard treatment for stiff knee gait (SKG), but efficacy now seems less than that of distal RF release. The aim of the present study was to compare efficacy between the two. The study hypo
Autor:
Michel Perron, Xiaofeng Zhao, Richard L. Mackman, Robert Jordan, Daniel Byun, Raju Subramanian, Tomas Cihlar, Kwon Soo Chun, Diane Lye, Christopher A. Palmiotti, Darius Babusis, Hui Hon Chung, Scott Simonovich, Bin Ma, Sarah Wortman, Lijun Zhang, Gary Lee, Julie Chan, Maria M. Toteva, Eisuke Murakami, Kirsten M. Stray, Xianghan Lu, Jared Pitts, Dustin Siegel, John P. Bilello, Kimberly T. Barrett, Bindu Goyal, Cynthia Kim, Arya Vijjapurapu, Venice Du Pont, Adelle Vandersteen
Publikováno v:
Journal of Medicinal Chemistry. 64:5001-5017
A discovery program targeting respiratory syncytial virus (RSV) identified C-nucleoside 4 (RSV A2 EC50 = 530 nM) as a phenotypic screening lead targeting the RSV RNA-dependent RNA polymerase (RdRp). Prodrug exploration resulted in the discovery of re