Pasteurized Akkermansia muciniphila improves irritable bowel syndrome-like symptoms and related behavioral disorders in mice

Autor: Maëva Meynier, Valentine Daugey, Geoffroy Mallaret, Sandie Gervason, Mathieu Meleine, Julie Barbier, Youssef Aissouni, Stéphane Lolignier, Mathilde Bonnet, Denis Ardid, Willem M. De Vos, Matthias Van Hul, Peter Suenaert, Amandine Brochot, Patrice D. Cani, Frédéric A. Carvalho

Publikováno v: Gut Microbes, Vol 16, Iss 1 (2024)

ABSTRACTGut – brain communications disorders in irritable bowel syndrome (IBS) are associated with intestinal microbiota composition, increased gut permeability, and psychosocial disturbances. Symptoms of IBS are difficult to medicate, and hence mu

Externí odkaz: https://doaj.org/article/cb9803d64116443f855c9388193c7f9a

Single Subcutaneous Injection of Lysophosphatidyl-Choline Evokes ASIC3-Dependent Increases of Spinal Dorsal Horn Neuron Activity

Autor: Ludivine Pidoux, Kevin Delanoe, Julie Barbier, Fabien Marchand, Eric Lingueglia, Emmanuel Deval

Publikováno v: Frontiers in Molecular Neuroscience, Vol 15 (2022)

Lysophosphatidyl-choline (LPC), a member of the phospholipid family, is an emerging player in pain. It is known to modulate different pain-related ion channels, including Acid-Sensing Ion Channel 3 (ASIC3), a cationic channel mainly expressed in peri

Externí odkaz: https://doaj.org/article/b32653ae1ec44d44b20eb133327cc45a

The Class I HDAC Inhibitor, MS-275, Prevents Oxaliplatin-Induced Chronic Neuropathy and Potentiates Its Antiproliferative Activity in Mice

Autor: Sylvain Lamoine, Mélissa Cumenal, David A. Barriere, Vanessa Pereira, Mathilde Fereyrolles, Laëtitia Prival, Julie Barbier, Ludivine Boudieu, Emilie Brasset, Benjamin Bertin, Yoan Renaud, Elisabeth Miot-Noirault, Marie-Ange Civiale, David Balayssac, Youssef Aissouni, Alain Eschalier, Jérôme Busserolles

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 98, p 98 (2022)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, 2022, 23 (1), pp.98. ⟨10.3390/ijms23010098⟩
International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 98

Oxaliplatin, the first-line chemotherapeutic agent against colorectal cancer (CRC), induces peripheral neuropathies, which can lead to dose limitation and treatment discontinuation. Downregulation of potassium channels, which involves histone deacety

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbcca31e4a77d7756eac1dfe75d3d8f8
https://www.mdpi.com/1422-0067/23/1/98

Toll-like receptor 5 knock-out mice exhibit a specific low level of anxiety

Autor: Mathieu Meleine, Denis Ardid, S. Roumeau, Ludivine Boudieu, Youssef Aissouni, Frederic A. Carvalho, Amandine Lashermes, Andrew T. Gewirtz, Fabien Marchand, Al Mahdy Hamieh, Julie Barbier, G. Mallaret

Publikováno v: Brain, Behavior, and Immunity
Brain, Behavior, and Immunity, Elsevier, 2021, 93, pp.226-237. ⟨10.1016/j.bbi.2021.01.020⟩
Brain, Behavior, and Immunity, 2021, 93, pp.226-237. ⟨10.1016/j.bbi.2021.01.020⟩

While toll-like receptors (TLRs), which mediate innate immunity, are known to play an important role in host defense, recent work suggest their involvement in some integrated behaviors, including anxiety, depressive and cognitive functions. Here, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::511c26bf1257f1f9900176faacc2573c
https://doi.org/10.1016/j.bbi.2021.01.020

c-Jun/p38MAPK/ASIC3 pathways specifically activated by nerve growth factor through TrkA are crucial for mechanical allodynia development

Autor: Tanguy Chaumette, Mathieu Meleine, Aziz Moqrich, Amandine Lashermes, Frederic A. Carvalho, Alain Eschalier, Ludivine Boudieu, Fabien Marchand, Wassim Legha, Youssef Aissouni, Lauriane Delay, Sophie Antraigue, Julie Barbier, Denis Ardid

Publikováno v: Pain. 161:1109-1123

Mechanical allodynia is a cardinal sign of several inflammatory pain disorders where nerve growth factor, a prototypic neurotrophin, plays a crucial role by binding to TrkA receptors. Here, we took the advantage of our generated knock-in mouse model

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95391a0ee909a2e155b6218276182697
https://doi.org/10.1097/j.pain.0000000000001808