Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Juliano, Ndoj"'
Autor:
David S. Rogawski, Jing Deng, Hao Li, Hongzhi Miao, Dmitry Borkin, Trupta Purohit, Jiho Song, Jennifer Chase, Shuangjiang Li, Juliano Ndoj, Szymon Klossowski, EunGi Kim, Fengbiao Mao, Bo Zhou, James Ropa, Marta Z. Krotoska, Zhuang Jin, Patricia Ernst, Xiaomin Feng, Gang Huang, Kenichi Nishioka, Samantha Kelly, Miao He, Bo Wen, Duxin Sun, Andrew Muntean, Yali Dou, Ivan Maillard, Tomasz Cierpicki, Jolanta Grembecka
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
The histone methyltransferase ASH1L plays a role in various diseases, including cancer, and has been validated as a therapeutic target; however, no inhibitors of ASH1L have been reported. Here the authors present small molecule inhibitors of ASH1L an
Externí odkaz:
https://doaj.org/article/a51c519c90294569ac5da97219844f37
Autor:
Trupta Purohit, EunGi Kim, Mariusz Jaremko, Joshua M Ray, Hyo Je Cho, Shihan He, Hongzhi Miao, Felicia Gray, Caroline Nikolaidis, Łukasz Jaremko, Tomasz Cierpicki, Qingjie Zhao, Weijiang Ying, Jolanta Grembecka, Xiaotian Zhang, Monica L. Guzman, Shirish Shukla, Alyssa Winkler, Yao Yiwu, Jingya Wang, Russell J.H. Ryan, Paula González-Alonso, Juliano Ndoj, George Lund, Miranda L. Simes
Publikováno v:
Nature chemical biology
Polycomb repressive complex 1 (PRC1) is an essential chromatin-modifying complex that monoubiquitinates histone H2A and is involved in maintaining the repressed chromatin state. Emerging evidence suggests PRC1 activity in various cancers, rationalizi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be29ba28e75787c38128d3654fcd1836
https://doi.org/10.1038/s41589-021-00815-5
https://doi.org/10.1038/s41589-021-00815-5
Autor:
Sergei Zari, Juliano Ndoj, Jolanta Grembecka, Paula González-Alonso, Katarzyna Kempińska, Mykhaylo A. Potopnyk, Tomasz Cierpicki, Hongzhi Miao, Caroline Nikolaidis, Andrew D. Henderson, Huang Huang, Trupta Purohit, David S. Rogawski, Shirish Shukla, Christina A. Howard, Adolfo A. Ferrando, Hyo Je Cho, Joshua Abbott, Anna K. Mapp, Maria Luisa Sulis, Hao Li
Publikováno v:
Nature Chemical Biology. 16:1403-1410
The nuclear receptor-binding SET domain (NSD) family of histone methyltransferases is associated with various malignancies, including aggressive acute leukemia with NUP98-NSD1 translocation. While NSD proteins represent attractive drug targets, their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b50ddaa9b49c0f149319c06274c09039
https://doi.org/10.1038/s41589-020-0626-6
https://doi.org/10.1038/s41589-020-0626-6
Autor:
Shirish, Shukla, Weijiang, Ying, Felicia, Gray, Yiwu, Yao, Miranda L, Simes, Qingjie, Zhao, Hongzhi, Miao, Hyo Je, Cho, Paula, González-Alonso, Alyssa, Winkler, George, Lund, Trupta, Purohit, EunGi, Kim, Xiaotian, Zhang, Joshua M, Ray, Shihan, He, Caroline, Nikolaidis, Juliano, Ndoj, Jingya, Wang, Łukasz, Jaremko, Mariusz, Jaremko, Russell J H, Ryan, Monica L, Guzman, Jolanta, Grembecka, Tomasz, Cierpicki
Publikováno v:
Nature chemical biology. 17(7)
Polycomb repressive complex 1 (PRC1) is an essential chromatin-modifying complex that monoubiquitinates histone H2A and is involved in maintaining the repressed chromatin state. Emerging evidence suggests PRC1 activity in various cancers, rationalizi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5a253d998755f3560046fc8e6a7b49a1
https://pubmed.ncbi.nlm.nih.gov/34155403
https://pubmed.ncbi.nlm.nih.gov/34155403
Autor:
EunGi Kim, Brian M. Linhares, Tomasz Cierpicki, Hao Li, Hyo Je Cho, Hongzhi Miao, Jolanta Grembecka, Juliano Ndoj
Publikováno v:
ACS Chemical Biology. 13:2739-2746
GAS41 is a chromatin-associated protein that belongs to the YEATS family and is involved in the recognition of acetyl-lysine in histone proteins. A unique feature of GAS41 is the presence of a C-terminal coiled-coil domain, which is responsible for p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c88ef052e41d3cc8cfa938710380cb9d
https://doi.org/10.1021/acschembio.8b00674
https://doi.org/10.1021/acschembio.8b00674
Two Loops Undergoing Concerted Dynamics Regulate the Activity of the ASH1L Histone Methyltransferase
Autor:
Ivan Maillard, Jolanta Grembecka, Juliano Ndoj, David S. Rogawski, Hyo Je Cho, Tomasz Cierpicki
Publikováno v:
Biochemistry. 54:5401-5413
ASH1L (absent, small, or homeotic-like 1) is a histone methyltransferase (HMTase) involved in gene activation that is overexpressed in multiple forms of cancer. Previous studies of ASH1L's catalytic SET domain identified an autoinhibitory loop that b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ad5906d6b3cd28454c2c03f3a5300d0
https://doi.org/10.1021/acs.biochem.5b00697
https://doi.org/10.1021/acs.biochem.5b00697
Autor:
Rogawski, David S., Juliano Ndoj, Hyo Je Cho, Maillard, Ivan, Grembecka, Jolanta, Cierpicki, Tomasz
Publikováno v:
Biochemistry; 9/8/2015, Vol. 54 Issue 35, p5401-5413, 13p