Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Julianne N. P. Smith"'
Autor:
Courtney L. Finch, Thomas H. King, Kendra J. Alfson, Katie A. Albanese, Julianne N. P. Smith, Paul Smock, Jocelyn Jakubik, Yenny Goez-Gazi, Michal Gazi, John W. Dutton, Elizabeth A. Clemmons, Marc E. Mattix, Ricardo Carrion, Thomas Rudge, Alex Ridenour, Sovann F. Woodin, Ruth Hunegnaw, Nancy J. Sullivan, Rong Xu
Publikováno v:
Vaccines, Vol 10, Iss 11, p 1935 (2022)
Marburg virus (MARV) is a virus of high human consequence with a case fatality rate of 24–88%. The global health and national security risks posed by Marburg virus disease (MVD) underscore the compelling need for a prophylactic vaccine, but no cand
Externí odkaz:
https://doaj.org/article/e79916c895fc4bc1a38bf77fcd628996
Autor:
Alan B. Dogan, Nathan A. Rohner, Julianne N. P. Smith, Jessica A. Kilgore, Noelle S. Williams, Sanford D. Markowitz, Horst A. von Recum, Amar B. Desai
Publikováno v:
Pharmaceutics, Vol 14, Iss 1, p 85 (2021)
As the prevalence of age-related fibrotic diseases continues to increase, novel antifibrotic therapies are emerging to address clinical needs. However, many novel therapeutics for managing chronic fibrosis are small-molecule drugs that require freque
Externí odkaz:
https://doaj.org/article/bc298c0bb9c04d99956ae53500cc67f7
Autor:
Won Jin Ho, Julianne N P Smith, Young Soo Park, Matthew Hadiono, Kelsey Christo, Alvin Jogasuria, Yongyou Zhang, Alyssia V Broncano, Lakshmi Kasturi, Dawn M Dawson, Stanton L Gerson, Sanford D Markowitz, Amar B Desai
Publikováno v:
PLoS ONE, Vol 17, Iss 5, p e0268787 (2022)
Emerging evidence implicates the eicosanoid molecule prostaglandin E2 (PGE2) in conferring a regenerative phenotype to multiple organ systems following tissue injury. As aging is in part characterized by loss of tissue stem cells' regenerative capaci
Externí odkaz:
https://doaj.org/article/1d5311542b3a499489eef5c722b323e2
Autor:
Julianne N P Smith, Yubin Zhang, Jing Jing Li, Amanda McCabe, Hui Jin Jo, Jackson Maloney, Katherine C MacNamara
Publikováno v:
PLoS Pathogens, Vol 14, Iss 8, p e1007234 (2018)
Type I interferons (IFNα/β) regulate diverse aspects of host defense, but their impact on hematopoietic stem and progenitor cells (HSC/HSPCs) during infection remains unclear. Hematologic impairment can occur in severe infections, thus we sought to
Externí odkaz:
https://doaj.org/article/fc207cba318f4c0181fb004bb2192238
Publikováno v:
Stem Cell Reports
Summary Severe infection can dramatically alter blood production, but the mechanisms driving hematopoietic stem and progenitor cell (HSC/HSPC) loss have not been clearly defined. Using Ixodes ovatus Ehrlichia (IOE), a tick-borne pathogen that causes
Autor:
Julianne N. P. Smith, Jackson Maloney, Angelica Costello, Amanda McCabe, Divya S. Katikaneni, Katherine C. MacNamara
Publikováno v:
Haematologica
Severe aplastic anemia (SAA) results from profound hematopoietic stem cell loss. T cells and interferon gamma (IFNγ) have long been associated with SAA, yet the underlying mechanisms driving hematopoietic stem cell loss remain unknown. Using a mouse
Autor:
Jane L. Liesveld, Laura M. Calvi, Allison J. Li, Mark W. LaMere, Andrew McDavid, Amanda McCabe, Jason R. Myers, Katherine C. MacNamara, James Palis, Michael W. Becker, Benjamin J. Frisch, Archibald S. Perkins, Jerry Saunders, John M. Ashton, Vyacheslav A. Korshunov, Sarah E. Latchney, Kathleen E. McGrath, Fátima Rivera-Escalera, Corey M. Hoffman, Michael R. Elliott, Julianne N. P. Smith
Publikováno v:
JCI Insight. 4
The bone marrow microenvironment (BMME) contributes to the regulation of hematopoietic stem cell (HSC) function, though its role in age-associated lineage skewing is poorly understood. Here we show that dysfunction of aged marrow macrophages (Mφs) d
Publikováno v:
Frontiers in Immunology, Vol 7 (2016)
Frontiers in Immunology
Frontiers in Immunology
Aplastic anemia (AA) occurs when the bone marrow fails to support production of all three lineages of blood cells, which are necessary for tissue oxygenation, infection control, and hemostasis. The etiology of acquired AA is elusive in the vast major
Autor:
Yumie Rhee, Jonathan M. Weber, Miles J. Basil, Julianne N. P. Smith, Olga Bromberg, Laura M. Calvi, Benjamin J. Frisch, Teresita Bellido
Publikováno v:
Blood. 119:2489-2499
Microenvironmental expansion of hematopoietic stem cells (HSCs) is induced by treatment with parathyroid hormone (PTH) or activation of the PTH receptor (PTH1R) in osteoblastic cells; however, the osteoblastic subset mediating this action of PTH is u
Autor:
James Palis, Michael Rusty Elliott, Laura M. Calvi, Rakhil Rubinova, Jason R. Myers, Michael W. Becker, Allison J. Li, Jane L. Liesveld, Corey M. Hoffman, Sarah E Latchney, Archibald S. Perkins, Frank Akwaa, Mark LaMere, Katherine C. MacNamara, Julianne N. P. Smith, Benjamin J. Frisch, Amanda McCabe, John M. Ashton
Publikováno v:
Blood. 130:95-95
While hematopoietic stem cells (HSCs)-intrinsic effects of aging have been explored, less is known about how HSC support is altered by the aged bone marrow microenvironment (BMME). To assess the role of the BMME in HSC aging, we compared the BMME in