Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Julianne N. P. Smith"'
Autor:
Courtney L. Finch, Thomas H. King, Kendra J. Alfson, Katie A. Albanese, Julianne N. P. Smith, Paul Smock, Jocelyn Jakubik, Yenny Goez-Gazi, Michal Gazi, John W. Dutton, Elizabeth A. Clemmons, Marc E. Mattix, Ricardo Carrion, Thomas Rudge, Alex Ridenour, Sovann F. Woodin, Ruth Hunegnaw, Nancy J. Sullivan, Rong Xu
Publikováno v:
Vaccines, Vol 10, Iss 11, p 1935 (2022)
Marburg virus (MARV) is a virus of high human consequence with a case fatality rate of 24–88%. The global health and national security risks posed by Marburg virus disease (MVD) underscore the compelling need for a prophylactic vaccine, but no cand
Externí odkaz:
https://doaj.org/article/e79916c895fc4bc1a38bf77fcd628996
Autor:
Alan B. Dogan, Nathan A. Rohner, Julianne N. P. Smith, Jessica A. Kilgore, Noelle S. Williams, Sanford D. Markowitz, Horst A. von Recum, Amar B. Desai
Publikováno v:
Pharmaceutics, Vol 14, Iss 1, p 85 (2021)
As the prevalence of age-related fibrotic diseases continues to increase, novel antifibrotic therapies are emerging to address clinical needs. However, many novel therapeutics for managing chronic fibrosis are small-molecule drugs that require freque
Externí odkaz:
https://doaj.org/article/bc298c0bb9c04d99956ae53500cc67f7
Publikováno v:
Stem Cell Reports
Summary Severe infection can dramatically alter blood production, but the mechanisms driving hematopoietic stem and progenitor cell (HSC/HSPC) loss have not been clearly defined. Using Ixodes ovatus Ehrlichia (IOE), a tick-borne pathogen that causes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a290777ec66b5d993d5ccd089e1f072b
https://pubmed.ncbi.nlm.nih.gov/34798063
https://pubmed.ncbi.nlm.nih.gov/34798063
Autor:
Won Jin Ho, Julianne N. P. Smith, Young Soo Park, Matthew Hadiono, Kelsey Christo, Alvin Jogasuria, Yongyou Zhang, Alyssia V. Broncano, Lakshmi Kasturi, Dawn M. Dawson, Stanton L. Gerson, Sanford D. Markowitz, Amar B. Desai
Publikováno v:
PLOS ONE. 17:e0268787
Emerging evidence implicates the eicosanoid molecule prostaglandin E2 (PGE2) in conferring a regenerative phenotype to multiple organ systems following tissue injury. As aging is in part characterized by loss of tissue stem cells’ regenerative capa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50d2029ea7cc7c45c0c49a8f07ff7f4d
https://doi.org/10.1371/journal.pone.0268787
https://doi.org/10.1371/journal.pone.0268787
Autor:
Julianne N. P. Smith, Jackson Maloney, Angelica Costello, Amanda McCabe, Divya S. Katikaneni, Katherine C. MacNamara
Publikováno v:
Haematologica
Severe aplastic anemia (SAA) results from profound hematopoietic stem cell loss. T cells and interferon gamma (IFNγ) have long been associated with SAA, yet the underlying mechanisms driving hematopoietic stem cell loss remain unknown. Using a mouse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eb1ecfede862e36b7969115228a9321
https://doi.org/10.3324/haematol.2018.189449
https://doi.org/10.3324/haematol.2018.189449
Autor:
Jane L. Liesveld, Laura M. Calvi, Allison J. Li, Mark W. LaMere, Andrew McDavid, Amanda McCabe, Jason R. Myers, Katherine C. MacNamara, James Palis, Michael W. Becker, Benjamin J. Frisch, Archibald S. Perkins, Jerry Saunders, John M. Ashton, Vyacheslav A. Korshunov, Sarah E. Latchney, Kathleen E. McGrath, Fátima Rivera-Escalera, Corey M. Hoffman, Michael R. Elliott, Julianne N. P. Smith
Publikováno v:
JCI Insight. 4
The bone marrow microenvironment (BMME) contributes to the regulation of hematopoietic stem cell (HSC) function, though its role in age-associated lineage skewing is poorly understood. Here we show that dysfunction of aged marrow macrophages (Mφs) d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15e80cb18df52b11b02cb86e9bf3b2fe
https://doi.org/10.1172/jci.insight.124213
https://doi.org/10.1172/jci.insight.124213
Autor:
Julianne N. P. Smith, Yubin Zhang, Katherine C. MacNamara, Hui Jin Jo, Jackson Maloney, Jing Jing Li, Amanda McCabe
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 14, Iss 8, p e1007234 (2018)
PLoS Pathogens, Vol 14, Iss 8, p e1007234 (2018)
Type I interferons (IFNα/β) regulate diverse aspects of host defense, but their impact on hematopoietic stem and progenitor cells (HSC/HSPCs) during infection remains unclear. Hematologic impairment can occur in severe infections, thus we sought to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4871518d41634c273aa6b28f7a778ad6
http://europepmc.org/articles/PMC6095620
http://europepmc.org/articles/PMC6095620
Publikováno v:
Frontiers in Immunology, Vol 7 (2016)
Frontiers in Immunology
Frontiers in Immunology
Aplastic anemia (AA) occurs when the bone marrow fails to support production of all three lineages of blood cells, which are necessary for tissue oxygenation, infection control, and hemostasis. The etiology of acquired AA is elusive in the vast major
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6c9698d2687a65e8a517c0326f9569b
Autor:
Yumie Rhee, Jonathan M. Weber, Miles J. Basil, Julianne N. P. Smith, Olga Bromberg, Laura M. Calvi, Benjamin J. Frisch, Teresita Bellido
Publikováno v:
Blood. 119:2489-2499
Microenvironmental expansion of hematopoietic stem cells (HSCs) is induced by treatment with parathyroid hormone (PTH) or activation of the PTH receptor (PTH1R) in osteoblastic cells; however, the osteoblastic subset mediating this action of PTH is u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7bf3a60c806c905c1e1fe64bb9a6d5a
https://doi.org/10.1182/blood-2011-06-360933
https://doi.org/10.1182/blood-2011-06-360933
Autor:
James Palis, Michael Rusty Elliott, Laura M. Calvi, Rakhil Rubinova, Jason R. Myers, Michael W. Becker, Allison J. Li, Jane L. Liesveld, Corey M. Hoffman, Sarah E Latchney, Archibald S. Perkins, Frank Akwaa, Mark LaMere, Katherine C. MacNamara, Julianne N. P. Smith, Benjamin J. Frisch, Amanda McCabe, John M. Ashton
Publikováno v:
Blood. 130:95-95
While hematopoietic stem cells (HSCs)-intrinsic effects of aging have been explored, less is known about how HSC support is altered by the aged bone marrow microenvironment (BMME). To assess the role of the BMME in HSC aging, we compared the BMME in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8b6ef70330e61941bcf91cb2c05026d
https://doi.org/10.1182/blood.v130.suppl_1.95.95
https://doi.org/10.1182/blood.v130.suppl_1.95.95