Zobrazeno 1 - 10 of 13 pro vyhledávání: '"Julianne D. Halley"'
1
Akademický článek
A conceptual and computational framework for modelling and understanding the non-equilibrium gene regulatory networks of mouse embryonic stem cells.
Autor: Richard B Greaves, Sabine Dietmann, Austin Smith, Susan Stepney, Julianne D Halley
Publikováno v: PLoS Computational Biology, Vol 13, Iss 9, p e1005713 (2017)
The capacity of pluripotent embryonic stem cells to differentiate into any cell type in the body makes them invaluable in the field of regenerative medicine. However, because of the complexity of both the core pluripotency network and the process of
Externí odkaz: https://doaj.org/article/4e7092c5c9ce42feaa143d9ccc1a5031
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2
Akademický článek
A general model for binary cell fate decision gene circuits with degeneracy: indeterminacy and switch behavior in the absence of cooperativity.
Autor: Mircea Andrecut, Julianne D Halley, David A Winkler, Sui Huang
Publikováno v: PLoS ONE, Vol 6, Iss 5, p e19358 (2011)
BACKGROUND: The gene regulatory circuit motif in which two opposing fate-determining transcription factors inhibit each other but activate themselves has been used in mathematical models of binary cell fate decisions in multipotent stem or progenitor
Externí odkaz: https://doaj.org/article/1b93eff8553740aaaa30ed93d38b9dcf
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3
Self-organizing circuitry and emergent computation in mouse embryonic stem cells
Autor: David A. Winkler, Tuezer Kalkan, Kate Smith-Miles, Julianne D. Halley, Sui Huang, Austin Smith
Publikováno v: Stem Cell Research
Stem Cell Research; Vol 8
Pluripotency is a cellular state of multiple options. Here, we highlight the potential for self-organization to contribute to stem cell fate computation. A new way of considering regulatory circuitry is presented that describes the expression of each
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::286561ecb5f0bdd6286e6bc581f7de7a
https://doi.org/10.1016/j.scr.2011.11.001
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5
Toward a Rosetta stone for the stem cell genome: Stochastic gene expression, network architecture, and external influences
Autor: Frank R. Burden, David A. Winkler, Julianne D. Halley
Publikováno v: Stem Cell Research. 1(3):157-168
We review literature relating to three types of factors known to influence stem cell behavior. These factors are stochastic gene expression, regulatory network architecture, and the influence of external signals, such as those emanating from the nich
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5619de9dca050a8ba487057250c096f
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7
Critical-like self-organization and natural selection: two facets of a single evolutionary process?
Autor: David A. Winkler, Julianne D. Halley
Publikováno v: Bio Systems. 92(2)
We argue that critical-like dynamics self-organize relatively easily in non-equilibrium systems, and that in biological systems such dynamics serve as templates upon which natural selection builds further elaborations. These critical-like states can
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3355c8c96d17a5ef31ff9167f5c3c08b
https://pubmed.ncbi.nlm.nih.gov/18353531
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8
Classification of Self-Organization and Emergence in Chemical and Biological Systems
Autor: David A. Winkler, Julianne D. Halley
Publikováno v: ChemInform. 38
Most chemical and biological systems are complex, but the application of complex systems science to these fields is relatively new compared to the traditional reductionist approaches. Complexity can provide a new paradigm for understanding the behavi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a78838e71af88691279276be07bc7949
https://doi.org/10.1002/chin.200718269
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10
Rapid self-organized criticality: Fractal evolution in extreme environments
Autor: Suzanne Sadedin, Julianne D. Halley, Wentian Li, Andrew C. Warden
Publikováno v: Physical Review E. 70
We introduce the phenomenon of rapid self-organized criticality (RSOC) and show that, like some models of self-organized criticality (SOC), RSOC generates scale-invariant event distributions and 1/f noise. Unlike SOC, however, RSOC persists despite m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dfbd0d0d200a4ebddeba24412db6a51
https://doi.org/10.1103/physreve.70.036118
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