Výsledky vyhledávání - "Julianna L. Sun"

Akademický článek

Novel Prion Strain as Cause of Chronic Wasting Disease in a Moose, Finland

Autor: Julianna L. Sun, Sehun Kim, Jenna Crowell, Bailey K. Webster, Emma K. Raisley, Diana C. Lowe, Jifeng Bian, Sirkka-Liisa Korpenfelt, Sylvie L. Benestad, Glenn C. Telling

Publikováno v: Emerging Infectious Diseases, Vol 29, Iss 2, Pp 323-332 (2023)

Our previous studies using gene-targeted mouse models of chronic wasting disease (CWD) demonstrated that Norway and North America cervids are infected with distinct prion strains that respond differently to naturally occurring amino acid variation at

Externí odkaz: https://doaj.org/article/831123ef9c134d55b29112bf630a78f7

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Akademický článek

Adaptive selection of a prion strain conformer corresponding to established North American CWD during propagation of novel emergent Norwegian strains in mice expressing elk or deer prion protein.

Publikováno v: PLoS Pathogens, Vol 17, Iss 7, p e1009748 (2021)

Prions are infectious proteins causing fatal, transmissible neurodegenerative diseases of animals and humans. Replication involves template-directed refolding of host encoded prion protein, PrPC, by its infectious conformation, PrPSc. Following its d

Externí odkaz: https://doaj.org/article/bea6273ddd5944c1a6d5966be71ea6e1

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Akademický článek

HIV induces synaptic hyperexcitation via cGMP-dependent protein kinase II activation in the FIV infection model.

Autor: Keira Sztukowski, Kaila Nip, Paige N Ostwald, Matheus F Sathler, Julianna L Sun, Jiayi Shou, Emily T Jorgensen, Travis E Brown, John H Elder, Craig Miller, Franz Hofmann, Sue VandeWoude, Seonil Kim

Publikováno v: PLoS Biology, Vol 16, Iss 7, p e2005315 (2018)

Over half of individuals infected with human immunodeficiency virus (HIV) suffer from HIV-associated neurocognitive disorders (HANDs), yet the molecular mechanisms leading to neuronal dysfunction are poorly understood. Feline immunodeficiency virus (

Externí odkaz: https://doaj.org/article/cb3edb7603b74952a7c44e6713461289

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A novel prion strain is responsible for the first case of chronic wasting disease in Finnish moose

Autor: Julianna L. Sun, Jifeng Bian, Sehun Kim, Jenna Crowell, Bailey K. Webster, Emma K. Raisley, Sirkka-Liisa Korpenfelt, Sylvie L. Benestad, Glenn C. Telling

Concern is mounting over the global emergence, expanding host range, and uncertain zoonotic potential of chronic wasting disease (CWD), a fatal, infectious disease of cervids caused by prions. Our previous studies using genetically modified CWD-susce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c691bda089a3ccbff930c0e240f59e09
https://doi.org/10.1101/2022.07.11.499602

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Co-activation of selective nicotinic acetylcholine receptors is required to reverse beta amyloid–induced Ca2+ hyperexcitation

Autor: Kaila A. Nip, Kaitlyn Ko, Susan Tsunoda, Sarah A. Stokoe, Jiayi Shou, Seonil Kim, Jessica P. Roberts, Matheus F. Sathler, Julianna L. Sun

Publikováno v: Neurobiology of Aging. 84:166-177

Beta-amyloid (Aβ) peptide accumulation has long been implicated in the pathogenesis of Alzheimer's disease (AD). Hippocampal network hyperexcitability in the early stages of the disease leads to increased epileptiform activity and eventually cogniti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b804cbca388b168ca2e0e261ecf6bceb
https://doi.org/10.1016/j.neurobiolaging.2019.09.005

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Co-activation of selective nicotinic acetylcholine receptors is required to reverse beta amyloid-induced Ca

Autor: Julianna L, Sun, Sarah A, Stokoe, Jessica P, Roberts, Matheus F, Sathler, Kaila A, Nip, Jiayi, Shou, Kaitlyn, Ko, Susan, Tsunoda, Seonil, Kim

Publikováno v: Neurobiol Aging

Beta-amyloid (Aβ) peptide accumulation has long been implicated in the pathogenesis of Alzheimer’s disease (AD). Hippocampal network hyperexcitability in the early stages of the disease leads to increased epileptiform activity and eventually cogni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::65d4a3a64adc5dccedaba3e9769c9ae2
https://pubmed.ncbi.nlm.nih.gov/31629115

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HIV induces synaptic hyperexcitation via cGMP-dependent protein kinase II activation in the FIV infection model

Autor: Paige N. Ostwald, Julianna L. Sun, Seonil Kim, Matheus F. Sathler, Franz Hofmann, Jiayi Shou, Emily T. Jorgensen, Sue VandeWoude, Travis E. Brown, Kaila A. Nip, Keira Sztukowski, John H. Elder, Craig Miller

Publikováno v: PLoS Biology
PLoS Biology, Vol 16, Iss 7, p e2005315 (2018)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f9a92ddd406ba5c2e302281350d573a
https://pubmed.ncbi.nlm.nih.gov/30052626

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Lack of TRPM5-Expressing Microvillous Cells in Mouse Main Olfactory Epithelium Leads to Impaired Odor-Evoked Responses and Olfactory-Guided Behavior in a Challenging Chemical Environment

Autor: Tatsuya Ogura, Hiroyuki Arakawa, Weihong Lin, Ichiro Matsumoto, Kayla Lemons, Julianna L. Sun, Imad Aoudé, Justin Chang, Zi-Ying Fu, Kenechukwu Mbonu

Publikováno v: eNeuro

Visual Abstract
The mammalian main olfactory epithelium (MOE) modifies its activities in response to changes in the chemical environment. This process is essential for maintaining the functions of the olfactory system and the upper airway. Howev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::276cb8a7d646b3178290e16c79bb6590
http://europepmc.org/articles/PMC5467397

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