Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Julianna E. Debrah"'
Autor:
Kirk P. Conrad, Jonathan T. McGuane, Maria B. Grant, J. Peter Rubin, Jacqueline Novak, Yagna P. R. Jarajapu, Julianna E. Debrah, Mark S. Segal, Laura Sautina
Publikováno v:
Endocrinology. 152:2786-2796
The peptide hormone relaxin is a potent vasodilator with therapeutic potential in diseases complicated by vasoconstriction, including heart failure. However, the molecular mediators and magnitude of vasodilation may vary according to duration of expo
Autor:
Kirk P. Conrad, Jonathan T. McGuane, Michael S. Sacks, Sanjeev G. Shroff, Jamie Haney, Dan O. Debrah, Julianna E. Debrah
Publikováno v:
Journal of applied physiology (Bethesda, Md. : 1985). 111(1)
Administration of recombinant human relaxin (rhRLX) to conscious rats increases global arterial compliance, and small renal arteries (SRA) isolated from these rats demonstrate increased passive compliance. Here we characterize relaxin-induced vascula
Autor:
Jacqueline Novak, J. Peter Rubin, Kirk P. Conrad, Leslie A. Danielson, Jonathan T. McGuane, Julianna E. Debrah
Publikováno v:
Hypertension (Dallas, Tex. : 1979). 57(6)
Relaxin is emerging as an important vasodilator of pregnancy and is being tested for afterload reduction in acute heart failure. However, the mechanisms underlying relaxin-induced vasodilation are incompletely understood. The aims of this study were
Autor:
Julianna E. Debrah, Dan O. Debrah, Kirk P. Conrad, Sanjeev G. Shroff, J. Peter Rubin, Jonathan T. McGuane, Mark S. Segal
Publikováno v:
Annals of the New York Academy of Sciences. 1160
In this paper, the hemodynamic changes of normal pregnancy are reviewed and the underlying hormonal and molecular mechanisms are discussed. Among other findings related to these phenomena, our previous work has demonstrated the importance of relaxin