Inhibition of G protein-coupled receptor kinase 2 promotes unbiased downregulation of IGF-1 receptor and restrains malignant cell growth

Autor: Caitrin Crudden, Julianna Serly, Ada Girnita, Daniela Nedelcu, George A. Calin, Dawei Song, Sonia Cismas, Takashi Shibano, Enrique Fuentes-Mattei, Mihnea P. Dragomir, Andrei Adrian Tica, Leonard Girnita

Publikováno v: Cancer Research, 81(2), 501-515. American Association for Cancer Research Inc.
Crudden, C, Shibano, T, Song, D, Dragomir, M P, Cismas, S, Serly, J, Nedelcu, D, Fuentes-Mattei, E, Tica, A, Calin, G A, Girnita, A & Girnita, L 2021, ' Inhibition of G Protein–Coupled Receptor Kinase 2 Promotes Unbiased Downregulation of IGF1 Receptor and Restrains Malignant Cell Growth ', Cancer Research, vol. 81, no. 2, pp. 501-515 . https://doi.org/10.1158/0008-5472.CAN-20-1662
Crudden, C, Shibano, T, Song, D, Dragomir, M P, Cismas, S, Serly, J, Nedelcu, D, Fuentes-Mattei, E, Tica, A, Calin, G A, Girnita, A & Girnita, L 2021, ' Inhibition of G protein-coupled receptor kinase 2 promotes unbiased downregulation of IGF-1 receptor and restrains malignant cell growth ', Cancer Research, vol. 81, no. 2, pp. 501-515 . https://doi.org/10.1158/0008-5472.CAN-20-1662

The ability of a receptor to preferentially activate only a subset of available downstream signal cascades is termed biased signaling. Although comprehensively recognized for the G protein–coupled receptors (GPCR), this process is scarcely explored

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e21c7e9c4286ac0504758d5103d6ab87
https://doi.org/10.1158/0008-5472.can-20-1662

Dimeric 3,5-bis(benzylidene)-4-piperidones: A novel cluster of tumour-selective cytotoxins possessing multidrug-resistant properties

Autor: Shoko Iwamoto, Tomohiko Matsuta, Umashankar Das, Dennis K.J. Gorecki, Swagatika Das, Jonathan R. Dimmock, Julianna Serly, Naoki Umemura, Masami Kawase, Hiroshi Sakagami, Joseph Molnár

Publikováno v: European Journal of Medicinal Chemistry. 51:193-199

A series of bis[3,5-bis(benzylidene)-4-oxo-1-piperidinyl]amides 1 display potent cytotoxic properties towards a wide range of tumours. A number of the CC 50 and IC 50 values are in the range of 10 −8 M. Specifically, these compounds have the follow

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::001d18f4f4bbeafe1b6d7fc2454dd350
https://doi.org/10.1016/j.ejmech.2012.02.042

Synthesis and Comparison of the Antitumor Activities of Steroids on ABCB1-transfected Mouse Lymphoma and Human Ovary Carcinoma

Autor: László Hodoniczki, József Molnár, Julianna Serly, Csaba Somlai, Irén Vincze

Publikováno v: Letters in Drug Design & Discovery. 8:138-147

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::acf4ca8af23817a8491376ac73352327
https://doi.org/10.2174/157018011794183833

Molecular Docking Analysis of Steroid-based Copper Transporter 1 Inhibitors

Autor: Onat, Kadioglu, Julianna, Serly, Ean-Jeong, Seo, Irén, Vincze, Csaba, Somlai, Mohamed E M, Saeed, József, Molnár, Thomas, Efferth

Publikováno v: Anticancer research. 35(12)

Copper transporter 1 (CTR1) represents an important determinant of cisplatin resistance. A series of 35 semi-substituted steroids were recently investigated on cisplatin-resistant CTR1-expressing A2780cis ovarian carcinoma cells as well as their pare

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9200203c5875e6388cbc8b5b5ad05767
https://pubmed.ncbi.nlm.nih.gov/26637863

Rapid discrimination between Candida albicans and Candida dubliniensis by using real-time polymerase chain reaction

Autor: Julianna Serly, Ferenc Somogyvári, Elizabeth Nagy, Suhail Ahmad, Ilona Dóczi

Publikováno v: Diagnostic Microbiology and Infectious Disease. 58:367-369

Several phenotypic methods have been used for the differentiation of Candida albicans and Candida dubliniensis, but molecular investigations are considered most reliable in their diagnostic value. Here, we suggest a rapid real-time polymerase chain r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b5839b724b4bd65cf329a3def3ada2
https://doi.org/10.1016/j.diagmicrobio.2007.01.015