Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Juliane Weller"'
Autor:
Young Shik Shin, Nadezda Fomina, Christopher Johnson, Thomas Rocznik, Habib Ahmad, Rachel Patricia-Andrea Staley, Juliane Weller, Christoph Lang
Publikováno v:
Analytical Chemistry. 94:13171-13180
An electrochemical platform for generating and controlling a localized pH microenvironment on demand is proposed by employing a closed-loop control algorithm based on an iridium oxide pH sensor input. We use a combination of solution-borne quinones a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecd461a18650834b2a182941abe7616d
https://doi.org/10.1021/acs.analchem.2c02686
https://doi.org/10.1021/acs.analchem.2c02686
Autor:
Ananth Pallaseni, Elin Madli Peets, Jonas Koeppel, Juliane Weller, Thomas Vanderstichele, Uyen Linh Ho, Luca Crepaldi, Jolanda van Leeuwen, Felicity Allen, Leopold Parts
Publikováno v:
Nucleic acids research, vol. 50, no. 6, pp. 3551-3564
CRISPR/Cas base editors promise nucleotide-level control over DNA sequences, but the determinants of their activity remain incompletely understood. We measured base editing frequencies in two human cell lines for two cytosine and two adenine base edi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::448acd85457e7d5eddf6c599dc15c9f5
https://doi.org/10.1093/nar/gkac161
https://doi.org/10.1093/nar/gkac161
Autor:
Hayden C. Metsky, Nicole L. Welch, Priya P. Pillai, Nicholas J. Haradhvala, Laurie Rumker, Sreekar Mantena, Yibin B. Zhang, David K. Yang, Cheri M. Ackerman, Juliane Weller, Paul C. Blainey, Cameron Myhrvold, Michael Mitzenmacher, Pardis C. Sabeti
Publikováno v:
Nature Biotechnology. 40:1123-1131
Design of nucleic acid-based viral diagnostics typically follows heuristic rules and, to contend with viral variation, focuses on a genome’s conserved regions. A design process could, instead, directly optimize diagnostic effectiveness using a lear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef19118a82a6b27fbb5d6404195ec928
https://doi.org/10.1038/s41587-022-01213-5
https://doi.org/10.1038/s41587-022-01213-5
Autor:
Nicole L. Welch, Meilin Zhu, Catherine Hua, Juliane Weller, Marzieh Ezzaty Mirhashemi, Tien G. Nguyen, Sreekar Mantena, Matthew R. Bauer, Bennett M. Shaw, Cheri M. Ackerman, Sri Gowtham Thakku, Megan W. Tse, Jared Kehe, Marie-Martine Uwera, Jacqueline S. Eversley, Derek A. Bielwaski, Graham McGrath, Joseph Braidt, Jeremy Johnson, Felecia Cerrato, Gage K. Moreno, Lydia A. Krasilnikova, Brittany A. Petros, Gabrielle L. Gionet, Ewa King, Richard C. Huard, Samantha K. Jalbert, Michael L. Cleary, Nicholas A. Fitzgerald, Stacey B. Gabriel, Glen R. Gallagher, Sandra C. Smole, Lawrence C. Madoff, Catherine M. Brown, Matthew W. Keller, Malania M. Wilson, Marie K. Kirby, John R. Barnes, Daniel J. Park, Katherine J. Siddle, Christian T. Happi, Deborah T. Hung, Michael Springer, Bronwyn L. MacInnis, Jacob E. Lemieux, Eric Rosenberg, John A. Branda, Paul C. Blainey, Pardis C. Sabeti, Cameron Myhrvold
Publikováno v:
Nature Medicine. 28:1083-1094
The coronavirus disease 2019 (COVID-19) pandemic has demonstrated a clear need for high-throughput, multiplexed and sensitive assays for detecting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other respiratory viruses and their em
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f3ea8d1b520b0550568fd82b8c53484
https://doi.org/10.1038/s41591-022-01734-1
https://doi.org/10.1038/s41591-022-01734-1
Autor:
Jonas Koeppel, Juliane Weller, Elin Madli Peets, Ananth Pallaseni, Ivan Kuzmin, Uku Raudvere, Hedi Peterson, Fabio Giuseppe Liberante, Leopold Parts
Publikováno v:
Nature Biotechnology.
Most short sequences can be precisely written into a selected genomic target using prime editing; however, it remains unclear what factors govern insertion. We design a library of 3,604 sequences of various lengths and measure the frequency of their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c713398ca7bcb093a7bd3ecbfe465931
https://doi.org/10.1038/s41587-023-01678-y
https://doi.org/10.1038/s41587-023-01678-y
Publikováno v:
Annals of the New York Academy of Sciences. 1496:82-96
Antibiotic resistance is a worldwide and growing clinical problem. With limited drug development in the antibacterial space, combination therapy has emerged as a promising strategy to combat multidrug-resistant bacteria. Antibacterial combinations ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c1774f395a287e5b8186c44a8442188
https://doi.org/10.1111/nyas.14649
https://doi.org/10.1111/nyas.14649
Autor:
Ananth Pallaseni, Fabio Giuseppe Liberante, Elin Madli Peets, Jonas Koeppel, Leopold Parts, Juliane Weller
SUMMARYShort sequences can be precisely written into a selected genomic target using prime editing. This ability facilitates protein tagging, correction of pathogenic deletions, and many other exciting applications. However, it remains unclear what t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89034d65ff747e099f5b079f1314765a
https://doi.org/10.1101/2021.11.10.468024
https://doi.org/10.1101/2021.11.10.468024
Autor:
Felicity Allen, Ananth Pallaseni, Juliane Weller, Jonas Koeppel, Elin Madli Peets, Leopold Parts, Luca Crepaldi
Nucleotide-level control over DNA sequences is poised to power functional genomics studies and lead to new therapeutics. CRISPR/Cas base editors promise to achieve this ability, but the determinants of their activity remain incompletely understood. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::860249a369f3bbdddf7cc2d13272228e
https://doi.org/10.1101/2021.09.16.460622
https://doi.org/10.1101/2021.09.16.460622
Autor:
David K. Yang, Pardis C. Sabeti, Michael Mitzenmacher, Hayden C. Metsky, Laurie Rumker, Nicole L. Welch, Priya P. Pillai, Cheri M. Ackerman, Sreekar Mantena, Paul C. Blainey, Yibin B. Zhang, Nicholas J. Haradhvala, Cameron Myhrvold, Juliane Weller
Diagnostics, particularly for rapidly evolving viruses, stand to benefit from a principled, measurement-driven design that harnesses machine learning and vast genomic data—yet the capability for such design has not been previously built. Here, we d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2e10972233f5c9175f0ad457a26dd36
https://doi.org/10.1101/2020.11.28.401877
https://doi.org/10.1101/2020.11.28.401877