Unaltered hepatic wound healing response in male rats with ancestral liver injury

Autor: Johanna Beil, Juliane Perner, Lena Pfaller, Marie-Apolline Gérard, Alessandro Piaia, Arno Doelemeyer, Adi Wasserkrug Naor, Lori Martin, Aline Piequet, Valérie Dubost, Salah-Dine Chibout, Jonathan Moggs, Rémi Terranova

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)

Abstract The possibility that ancestral environmental exposure could result in adaptive inherited effects in mammals has been long debated. Numerous rodent models of transgenerational responses to various environmental factors have been published but

Externí odkaz: https://doaj.org/article/6e362dba6d34488f8bd47f36ce0464c8

Patient-specific cancer genes contribute to recurrently perturbed pathways and establish therapeutic vulnerabilities in esophageal adenocarcinoma

Autor: Thanos P. Mourikis, Lorena Benedetti, Elizabeth Foxall, Damjan Temelkovski, Joel Nulsen, Juliane Perner, Matteo Cereda, Jesper Lagergren, Michael Howell, Christopher Yau, Rebecca C. Fitzgerald, Paola Scaffidi, The Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium, Francesca D. Ciccarelli

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)

Identifying driver genes in unstable, heterogenous tumour types can be challenging. Here, Mourikis, Benedetti, Foxall and colleagues present a machine learning algorithm to tackle this problem in esophageal adenocarcinoma.

Externí odkaz: https://doaj.org/article/6525c04e989d4f92801eb2e25637bf6b

Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics

Autor: Xiaodun Li, Hayley E. Francies, Maria Secrier, Juliane Perner, Ahmad Miremadi, Núria Galeano-Dalmau, William J. Barendt, Laura Letchford, Genevieve M. Leyden, Emma K. Goffin, Andrew Barthorpe, Howard Lightfoot, Elisabeth Chen, James Gilbert, Ayesha Noorani, Ginny Devonshire, Lawrence Bower, Amber Grantham, Shona MacRae, Nicola Grehan, David C. Wedge, Rebecca C. Fitzgerald, Mathew J. Garnett

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)

Esophageal adenocarcinoma (EAC) has a poor 5-year survival rate and lacks robust preclinical models for use in research. Here, the authors show that newly derived organoids recapitulate the transcriptomic, genetic, and morphological landscape of the

Externí odkaz: https://doaj.org/article/aa2121583c394435847f94d0542851c4

Impact of mutations in Toll-like receptor pathway genes on esophageal carcinogenesis.

Autor: Daffolyn Rachael Fels Elliott, Juliane Perner, Xiaodun Li, Martyn F Symmons, Brett Verstak, Matthew Eldridge, Lawrence Bower, Maria O'Donovan, Nick J Gay, OCCAMS Consortium, Rebecca C Fitzgerald

Publikováno v: PLoS Genetics, Vol 13, Iss 5, p e1006808 (2017)

Esophageal adenocarcinoma (EAC) develops in an inflammatory microenvironment with reduced microbial diversity, but mechanisms for these influences remain poorly characterized. We hypothesized that mutations targeting the Toll-like receptor (TLR) path

Externí odkaz: https://doaj.org/article/795eeb65e0a5409c98148b4a71db3485

Endoscopic tumour morphology impacts survival in adenocarcinoma of the oesophagus

Autor: Simon L. Parsons, Monika Tripathi, Vijayendran Sujendran, E. Fidziukiewicz, Jim Davies, Ula Mahadeva, Annalise Katz-Summercorn, Neil A. Shepherd, A. Northrop, Simon Tavaré, James A. Gossage, Richard Berrisford, S Lishman, Michael F. Scott, Shaun R. Preston, W. Fickling, Andrew Hindmarsh, Jesper Lagergren, Juliane Perner, Peter Safranek, Hugh Barr, Grant Sanders, Francesca D. Ciccarelli, Xiaodun Li, D. Khoo, Paw Edwards, Helen G. Coleman, Timothy J. Underwood, Christopher J. Peters, D. Loureda, Ayesha Noorani, Laszlo Igali, Maria Secrier, Bhaskar Kumar, Ahmad Miremadi, Irshad Soomro, Wais Habib, Andrew Davies, George B. Hanna, Izhar Bagwan, Matthew D. Eldridge, Andy G. Lynch, S Suortamo, Rehan Haidry, Fuju Chang, Ginny Devonshire, John H. Saunders, Nick Carroll, Michael P. Lewis, Sonia Puig, Stephen J. Hayes, Charles Crichton, Olga Tucker, Sharmila Sothi, Christopher C.W. Hughes, Andrew D Beggs, R. de la Rue, J Zylstra, J. R. O'Neill, Vicki Save, Yeng Ang, Robert C. Walker, E Cheong, Krishna Moorthy, Laurence Lovat, Vicky Goh, Richard J E Skipworth, Richard C. Turkington, S Oakes, Gianmarco Contino, Sriganesh Jammula, R Bott, M O'Donovan, O Old, B Grace, Ricardo McEwen, C Harden, Barbara Nutzinger, Philippe Taniere, Rebecca C. Fitzgerald, Ben E. Byrne, Shalini Malhotra, Nicola Grehan, Damian T. McManus, Anna M. Grabowska, Andrew D. Sharrocks, Sujath Abbas, William R. C. Knight, Shona MacRae, Philip Kaye, Ted R. Hupp

Publikováno v: European Journal of Surgical Oncology. 46:2257-2261

Prognostication in oesophageal cancer on the basis of preoperative variables is challenging. Many of the accepted predictors of survival are only derived after surgical treatment and may be influenced by neoadjuvant therapy. This study aims to explor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::777069ab22a8ac8baa5c4506d8ef9ddb
https://doi.org/10.1016/j.ejso.2020.07.003