Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Juliane Lokau"'
Autor:
Ilyas Ahmad, Juliane Lokau, Birte Kespohl, Naveed Altaf Malik, Shahid Mahmood Baig, Roland Hartig, Daniel Behme, Roland Schwab, Janine Altmüller, Muhammad Jameel, Sören Mucha, Holger Thiele, Muhammad Tariq, Peter Nürnberg, Jeanette Erdmann, Christoph Garbers
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Craniosynostosis is characterized by the premature fusion and ossification of one or more of the sutures of the calvaria, often resulting in abnormal features of the face and the skull. In cases in which growth of the brain supersedes availa
Externí odkaz:
https://doaj.org/article/37abbe8ef1aa4c21a5485f639564dcf7
Publikováno v:
Genes and Diseases, Vol 10, Iss 2, Pp 373-376 (2023)
Externí odkaz:
https://doaj.org/article/4ec702fe34c847c3bb7d897919d7e45c
Autor:
Dominik M. Schulte, Georg H. Waetzig, Harald Schuett, Marlies Marx, Berenice Schulte, Christoph Garbers, Juliane Lokau, Ann-Kathrin Vlacil, Juliane Schulz, Anna K. Seoudy, Bernhard Schieffer, Philip Rosenstiel, Marcus Seeger, Matthias Laudes, Stefan Rose-John, Ulf Lützen, Karsten Grote, Stefan Schreiber
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Inflammation is a strong driver of atherosclerotic cardiovascular disease (ASCVD). There is a large unmet need for therapies that prevent or reduce excessive inflammation while avoiding systemic immunosuppression. We showed previously that selective
Externí odkaz:
https://doaj.org/article/d984510475674274bd6408ba7e87d06a
Autor:
Charlotte M. Flynn, Yvonne Garbers, Stefan Düsterhöft, Rielana Wichert, Juliane Lokau, Christian H. K. Lehmann, Diana Dudziak, Bernd Schröder, Christoph Becker-Pauly, Stefan Rose-John, Samadhi Aparicio-Siegmund, Christoph Garbers
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract The cytokine interleukin-6 (IL-6) fulfills its pleiotropic functions via different modes of signaling. Regenerative and anti-inflammatory activities are mediated via classic signaling, in which IL-6 binds to the membrane-bound IL-6 receptor
Externí odkaz:
https://doaj.org/article/5fcbad4a86ec408db5a8eceac4164627
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103309- (2021)
Summary: Blocking the activity of cytokines is an efficient strategy to combat inflammatory diseases. Interleukin-6 (IL-6) fulfills its pro-inflammatory properties via its soluble receptor (IL-6 trans-signaling). The selective trans-signaling inhibit
Externí odkaz:
https://doaj.org/article/b3dee9db303a4a72ae6b113f86f759f1
Autor:
Antonin Gellrich, Franka Scharfenberg, Florian Peters, Martin Sammel, Ole Helm, Fred Armbrust, Frederike Schmidt, Juliane Lokau, Christoph Garbers, Susanne Sebens, Philipp Arnold, Christoph Becker-Pauly
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Meprin β is a metalloprotease associated with neurodegeneration, inflammation, extracellular matrix homeostasis, transendothelial cell migration, and cancer. In this study, we investigated two melanoma-associated variants of meprin β, both exhibiti
Externí odkaz:
https://doaj.org/article/c636de579977474cbd0a52a9602e4edc
Autor:
Juliane Lokau, Florian Kleinegger, Yvonne Garbers, Georg H Waetzig, Joachim Grötzinger, Stefan Rose-John, Johannes Haybaeck, Christoph Garbers
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0232612 (2020)
Tocilizumab is a humanized monoclonal antibody that is approved for the treatment of different human inflammatory diseases, including rheumatoid arthritis and cytokine release syndrome. Tocilizumab binds to the interleukin-6 receptor (IL-6R) and ther
Externí odkaz:
https://doaj.org/article/5db749b22fd241da932fe66822a64c9f
Autor:
Jonathan Martinez-Fabregas, Stephan Wilmes, Luopin Wang, Maximillian Hafer, Elizabeth Pohler, Juliane Lokau, Christoph Garbers, Adeline Cozzani, Paul K Fyfe, Jacob Piehler, Majid Kazemian, Suman Mitra, Ignacio Moraga
Publikováno v:
eLife, Vol 8 (2019)
Cytokines activate signaling via assembly of cell surface receptors, but it is unclear whether modulation of cytokine-receptor binding parameters can modify biological outcomes. We have engineered IL-6 variants with different affinities to gp130 to i
Externí odkaz:
https://doaj.org/article/1b051ad15afd4701b89407a5956a40df
Autor:
Niloufar Monhasery, Jens Moll, Carly Cuman, Manuel Franke, Larissa Lamertz, Rebecca Nitz, Boris Görg, Dieter Häussinger, Juliane Lokau, Doreen M. Floss, Roland Piekorz, Eva Dimitriadis, Christoph Garbers, Jürgen Scheller
Publikováno v:
Cell Reports, Vol 16, Iss 4, Pp 1067-1081 (2016)
Interleukin (IL)-11 signaling is involved in various processes, including epithelial intestinal cell regeneration and embryo implantation. IL-11 signaling is initiated upon binding of IL-11 to IL-11R1 or IL-11R2, two IL-11α-receptor splice variants,
Externí odkaz:
https://doaj.org/article/5b4bef001d7b44ef9b5292a02f4bbbdc
Autor:
Philipp Arnold, Wiebke Lückstädt, Wenjia Li, Inga Boll, Juliane Lokau, Christoph Garbers, Ralph Lucius, Stefan Rose-John, Christoph Becker-Pauly
Publikováno v:
Cells, Vol 9, Iss 5, p 1307 (2020)
Interleukin-6 (IL-6) signaling is a crucial regulatory event important for many biological functions, such as inflammation and tissue regeneration. Accordingly, several pathological conditions are associated with dysregulated IL-6 activity, making it
Externí odkaz:
https://doaj.org/article/465f66a6720449e6a6f8f8fa03786b68