Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Juliana Ruiz-Caro"'
Autor:
Julian Tirado-Rives, Raymond T. Chung, William L. Jorgensen, Todd J. Sullivan, Ebrahim Mohamed, Christopher M. Bailey, Pinar Iyidogan, Juliana Ruiz-Caro, Roger Hunter, Karen S. Anderson
Publikováno v:
Journal of Medicinal Chemistry. 56:3959-3968
Human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) is a major target for currently approved anti-HIV drugs. These drugs are divided into two classes: nucleoside and non-nucleoside reverse transcriptase inhibitors (NRTIs and NNRTIs).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b67274493c5213e17c488bd2ecb72d5
https://doi.org/10.1021/jm400160s
https://doi.org/10.1021/jm400160s
Autor:
José Marco-Contelles, Juliana Ruiz-Caro, Emily Mainetti, Max Malacria, Louis Fensterbank, Priscille Devin
Publikováno v:
Tetrahedron. 58:1147-1158
The intramolecular Pauson–Khand (PK) reaction of 4-bromomethyldimethylsilyloxy-4-ethynyl-6,6-dimethyloct-1-en-7-yne ( 1 ), the differently functionalized 4-ethynyl-octa-1,7-dienes ( 2–6 ), and 5-ethynyl-5-hydroxy-2,4,4-trimethyl-nona-1,8-diene (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::712641aa7071899fe50c49bd7075fa31
https://doi.org/10.1016/s0040-4020(01)01209-1
https://doi.org/10.1016/s0040-4020(01)01209-1
Publikováno v:
Tetrahedron Letters. 42:1515-1517
The unexpected reduction of the acetal moiety at the glycosidic C1O-exo bond in the bis-heteroannulated-pyranosides 3 and 9 is a simple and new method for the synthesis of chiral and highly functionalized cyclopentanes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc4e29e18a2990f7e31e761f6bf5f77c
https://doi.org/10.1016/s0040-4039(00)02320-0
https://doi.org/10.1016/s0040-4039(00)02320-0
Publikováno v:
ChemInform. 31
The Pauson−Khand reaction on suitable 4-oxa-hept-1-en-6-ynes (1, 17) obtained from 3,4,6-tri-O-acetyl-d-glucal gives the cyclopentane-annulated pyranosides (2, 18) that can be efficiently and stere...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41ff626f9de88c678e96286ecbc4fb4a
https://doi.org/10.1002/chin.200009193
https://doi.org/10.1002/chin.200009193
Publikováno v:
ChemInform. 32
The unexpected reduction of the acetal moiety at the glycosidic C1O-exo bond in the bis-heteroannulated-pyranosides 3 and 9 is a simple and new method for the synthesis of chiral and highly functionalized cyclopentanes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ab8cb9bf3ae4730aa80e3799b519fc5
https://doi.org/10.1002/chin.200121182
https://doi.org/10.1002/chin.200121182
Publikováno v:
ChemInform. 33
The reaction of DIBALH with bis(heteroannulated)-pyranosides containing the perhydrofuro[2,3-b]pyran moiety is described. The hydride attack at the anomeric carbon (C-9a) resulted in the exclusive tetrahydrofuran ring opening. The selectivity of this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10e9ecbbbfc8d4bcf9a7af1d343f940e
https://doi.org/10.1002/chin.200206227
https://doi.org/10.1002/chin.200206227
Publikováno v:
ChemInform. 33
The synthesis and transformations of new annulated pyranosides are described. These adducts were prepared by Pauson–Khand reaction on differently functionalized prop-2-ynyl-2,3-dideoxy-α- d -erythro-hex-2-enopyranosides (1–8). Compound 1 with a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4996a6b2ea9570c073d5cab32a98daad
https://doi.org/10.1002/chin.200208217
https://doi.org/10.1002/chin.200208217
Autor:
William L. Jorgensen, Andrew D. Hamilton, Aravind Basavapathruni, Juliana Ruiz-Caro, Julian Tirado-Rives, Karen S. Anderson
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(3)
Design principles are delineated for non-nucleoside inhibitors for HIV-1 reverse transcriptase (NNRTIs). Simultaneous optimization of binding affinity for wild-type RT, tolerance for viral mutations, and physical properties is pursued. Automated lead
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67965741fd040dc99080d94783ae9c57
https://pubmed.ncbi.nlm.nih.gov/16263277
https://pubmed.ncbi.nlm.nih.gov/16263277
Autor:
Andrew D. Hamilton, Juliana Ruiz-Caro, Christopher M. Bailey, Karen S. Anderson, Ligong Wang, Aravind Basavapathruni, Joseph T. Kim, William L. Jorgensen
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(3)
Following computational analyses, potential non-nucleoside inhibitors of HIV-1 reverse transcriptase have been pursued through synthesis and assaying for anti-viral activity. The general class Het–NH–Ph–U has been considered, where Het is an ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28d4a19ef2f6851387bf9bccfa3ba5fa
https://pubmed.ncbi.nlm.nih.gov/16298131
https://pubmed.ncbi.nlm.nih.gov/16298131
Publikováno v:
ChemInform. 35
The previously unknown stereostructure of glucolipsin A (1), a complex glycolipid endowed with glucokinase-activating properties, was unambiguously elucidated as (2R,2'R,3S,3'S) by comparison of its spectroscopic and analytical data with those of all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::138085b6695455e6847136e8fcff5605
https://doi.org/10.1002/chin.200422217
https://doi.org/10.1002/chin.200422217