Supplemental Figure 1 from Association of HO-1 and BRCA1 Is Critical for the Maintenance of Cellular Homeostasis in Prostate Cancer

Autor: Adriana De Siervi, Elba Vazquez, Nora Navone, Florencia Zalazar, Jimena Giudice, Juliana Porretti, Cintia Massillo, Cristian P. Moiola, Alejandra Paez, Geraldine Gueron, Paola De Luca, Estefanía Labanca

S1A. Cross-cancer alteration summary for BRCA1, HMOX1, NFE2L2 (9 studies / 3 genes). S1B. mRNA co-expression of gene pairs BRCA1/NRF2 and HO-1/NRF2 in 109 samples (Broad/Cornell, Nature Genetics 2012) and 56 samples (Broad/Cornell, Cell 2013), respec

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https://doi.org/10.1158/1541-7786.22514071.v1

CLCA2 epigenetic regulation by CTBP1, HDACs, ZEB1, EP300 and miR-196b-5p impacts prostate cancer cell adhesion and EMT in metabolic syndrome disease

Autor: Paola De Luca, Ana M. Cabanillas, Randolph C. Elble, Guillermo Nicolás Dalton, Kevin Gardner, Juliana Porretti, Paula Accialini, Georgina Daniela Scalise, Cintia Massillo, Esther Noemi Gerez, Adriana De Siervi, Paula Lucía Farré

Publikováno v: International Journal of Cancer. 143:897-906

Prostate cancer (PCa) is the most common cancer among men. Metabolic syndrome (MeS) is associated with increased PCa aggressiveness and recurrence. Previously, we proposed C-terminal binding protein 1 (CTBP1), a transcriptional co-repressor, as a mol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3fba42c235ec0c406aa96fc70442f19a
https://doi.org/10.1002/ijc.31379

CTBP1 depletion on prostate tumors deregulates miRNA/mRNA expression and impairs cancer progression in metabolic syndrome mice

Autor: Juliana Porretti, Alejandra Paez, Geraldine Gueron, Guillermo Nicolás Dalton, Kevin Gardner, Georgina Daniela Scalise, Paula Lucía Farré, Adriana De Siervi, Rocío Belén Duca, Cintia Massillo, Paola De Luca

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Cell Death and Disease, Vol 10, Iss 4, Pp 1-12 (2019)
Cell Death & Disease

About 20% of prostate cancer (PCa) patients progress to metastatic disease. Metabolic syndrome (MeS) is a pathophysiological disorder that increases PCa risk and aggressiveness. C-terminal binding protein (CTBP1) is a transcriptional corepressor that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ea4aeb5e5eccf1945d6f43146e5b4c4

CTBP1/CYP19A1/estradiol axis together with adipose tissue impacts over prostate cancer growth associated to metabolic syndrome

Autor: Cintia, Massillo, Guillermo Nicolás, Dalton, Juliana, Porretti, Georgina Daniela, Scalise, Paula Lucía, Farré, Flavia, Piccioni, Florencia, Secchiari, Natalia, Pascuali, Colin, Clyne, Kevin, Gardner, Paola, De Luca, Adriana, De Siervi

Publikováno v: International journal of cancer. 144(5)

Metabolic syndrome (MeS) increases prostate cancer (PCa) risk and aggressiveness. C-terminal binding protein 1 (CTBP1) is a transcriptional co-repressor of tumor suppressor genes that is activated by low NAD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0098d1cb98c4d9f719a68da0b2b867d3
https://pubmed.ncbi.nlm.nih.gov/30152543

Association of HO-1 and BRCA1 is critical for the maintenance of cellular homeostasis in prostate cancer

Autor: Nora M. Navone, Florencia Zalazar, Estefania Labanca, Paola De Luca, Alejandra Paez, Cintia Massillo, Juliana Porretti, Elba Vazquez, Adriana De Siervi, Jimena Giudice, Geraldine Gueron, Cristian Pablo Moiola

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Prostate cancer is the second leading cause of cancer-related death in men worldwide. Many factors that participate in the development of prostate cancer promote imbalance in the redox state of the cell. Accumulation of reactive oxygen species causes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ff29d7b92a37da27b743796460b7e07
http://mcr.aacrjournals.org/content/13/11/1455.long