Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Juliana Lott Carvalho"'
Autor:
Amandda Évelin Silva-Carvalho, Elizabete Cristina Iseke Bispo, Ingrid Gracielle Martins da Silva, José Raimundo Correa, Juliana Lott Carvalho, Guilherme Martins Gelfuso, Felipe Saldanha-Araujo
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Ibrutinib (IB) is a tyrosine kinase inhibitor (TKI) that has immunomodulatory action and can be used as second-line therapy for steroid-refractory or steroid-resistant chronic Graft versus Host Disease (cGVHD). Mesenchymal stromal cells (MSC
Externí odkaz:
https://doaj.org/article/5f9d2e0d3db4484b947ab3deb0834acc
Autor:
Lucas F. F. Albuquerque, Maria Victoria Souto, Felipe Saldanha-Araujo, Juliana Lott Carvalho, Tais Gratieri, Marcilio Cunha-Filho, Guilherme M. Gelfuso
Publikováno v:
Chemistry, Vol 6, Iss 2, Pp 272-282 (2024)
Ibrutinib (IBR) is a tyrosine kinase inhibitor investigated for treating solid and non-solid tumors. Considering the advantages that a topical application of IBR could generate in terms of dose reduction and side effects in skin cancer treatment, thi
Externí odkaz:
https://doaj.org/article/401779a63ef64831b15ea74756506a39
Autor:
Luma Dayane de Carvalho Filiú-Braga, Amanda Évelin Silva-Carvalho, Marielly Reis Resende Sousa, Juliana Lott Carvalho, Felipe Saldanha-Araujo
Publikováno v:
Heliyon, Vol 10, Iss 5, Pp e27085- (2024)
In recent years, histone methyltransferases (HMTs) have emerged as important therapeutic targets in cancer due to their oncogenic role. Herein, we used the GLP/G9a inhibitor UNC0646 to assess whether the inhibition of such HMTs could induce cell deat
Externí odkaz:
https://doaj.org/article/d2318d0547354d83a6f8c672525136aa
Autor:
Thuany Alencar-Silva, Rubén D Díaz-Martín, Mickelly Sousa dos Santos, Rivaldo Varejão Pasqual Saraiva, Michel Lopes Leite, Maria Tereza de Oliveira Rodrigues, Robert Pogue, Rosângela Andrade, Fabrício Falconi Costa, Nicolau Brito, Simoni Campos Dias, Juliana Lott Carvalho
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 6851 (2024)
Skin wound healing is coordinated by a delicate balance between proinflammatory and anti-inflammatory responses, which can be affected by opportunistic pathogens and metabolic or vascular diseases. Several antimicrobial peptides (AMPs) possess immuno
Externí odkaz:
https://doaj.org/article/77ece58efe8547f892f86a8335e6e11b
Autor:
Fernanda Vitelli Lins, Elizabete Cristina Iseke Bispo, Naomí Souza Rodrigues, Maria Victória Souto Silva, Juliana Lott Carvalho, Guilherme Martins Gelfuso, Felipe Saldanha-Araujo
Publikováno v:
Biomedicines, Vol 12, Iss 5, p 1012 (2024)
Ibrutinib, a tyrosine kinase inhibitor with a broad spectrum of action, has been successfully explored to treat hematological and solid cancers. Herein, we investigated the anti-cancer effect of Ibrutinib on melanoma cell lines. Cytotoxicity was eval
Externí odkaz:
https://doaj.org/article/311532a666b0483a8d0c21ce7d91752a
Autor:
Thuany Alencar-Silva, Stefhani Martins de Barcelos, Amandda Silva-Carvalho, Mauricio Gonçalves da Costa Sousa, Taia Maria Berto Rezende, Robert Pogue, Felipe Saldanha-Araújo, Octávio Luiz Franco, Mariana Boroni, Alessandra Zonari, Juliana Lott Carvalho
Publikováno v:
Cells, Vol 13, Iss 10, p 813 (2024)
Inflammation contributes to the onset and exacerbation of numerous age-related diseases, often manifesting as a chronic condition during aging. Given that cellular senescence fosters local and systemic inflammation, senotherapeutic interventions coul
Externí odkaz:
https://doaj.org/article/8952a063afe24cd49a56c8394c1f283d
Autor:
Maira Souza Oliveira Barreto, Juliana Lott Carvalho, Marcos Barrouin Melo, Ana Flávia Ribeiro Machado Michel, Marina Guimarães Ferreira, Ruthnéa Aparecida Lázaro Muzzi, Alfredo Miranda de Goes, Marilia Martins Melo
Publikováno v:
Brazilian Journal of Pharmaceutical Sciences, Vol 59 (2023)
Abstract Doxorubicin (Dox) is a medication used in the treatment of cancerous tumors and hematologic malignancies with potentially serious side effects, including the risk of cardiotoxicity. Flavonoids are plant metabolites with antioxidant propertie
Externí odkaz:
https://doaj.org/article/3eb29ef466974df19f6924ba9ccf711b
Autor:
Bruna Caroline de Carvalho, Tamires Vital, Jaqueline Osiro, Ciro Martins Gomes, Elza Noronha, Bruno Dallago, Ana de Cássia Rosa, Juliana Lott Carvalho, Luciana Hagström, Mariana Hecht, Nadjar Nitz
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Tegumentary leishmaniasis is a tropical disease caused by protozoa of the genus Leishmania. Clinically, the disease presents a broad spectrum of symptoms, the mechanisms underlying the development of lesions remaining to be fully elucidated. In the p
Externí odkaz:
https://doaj.org/article/7dcdef1fb4f84e568a4031e8278cdc73
Autor:
Thuany Alencar-Silva, Rubén D. Díaz-Martín, Alessandra Zonari, Daniel Foyt, Mylieneth Guiang, Robert Pogue, Felipe Saldanha-Araujo, Simoni Campos Dias, Octavio Luiz Franco, Juliana Lott Carvalho
Publikováno v:
Biomolecules, Vol 13, Iss 5, p 804 (2023)
In skin lesions, the development of microbial infection affects the healing process, increasing morbidity and mortality rates in patients with severe burns, diabetic foot, and other types of skin injuries. Synoeca-MP is an antimicrobial peptide (AMP)
Externí odkaz:
https://doaj.org/article/0ac65d7b0ed146ebafcd1c3ad553561e
Autor:
Ana Clara N. Brathwaite, Thuany Alencar-Silva, Larissa A. C. Carvalho, Maryana S. F. Branquinho, Ricardo Ferreira-Nunes, Marcilio Cunha-Filho, Guilherme M. Gelfuso, Silvya S. Maria-Engler, Juliana Lott Carvalho, Joyce K. R. Silva, Tais Gratieri
Publikováno v:
Molecules, Vol 27, Iss 18, p 5982 (2022)
Here, we verify the depigmenting action of Pouteria macrophylla fruit extract (EXT), incorporate it into a safe topical microemulsion and assess its effectiveness in a 3D pigmented skin model. Melanocytes-B16F10- were used to assess the EXT effects o
Externí odkaz:
https://doaj.org/article/68f7f0ef9b454bf6b082a5cda09cbb84