Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Juliana L. Asgian"'
Autor:
Heather Twin, Chau Mak, Francoise Pierard, Juan-Miguel Jimenez, Jeremy J. Clemens, Sam Sperry, John Studley, Andrew Miller, Dean Stamos, Andreas Termin, Philip N. Collier, Guy Brenchley, Juliana L. Asgian, Brett B. Busch, Jeffrey Abt, Sandra Lechner, Roger Heim, Tina B. Flores, Ray Gross, Dao Tran, Vadims Dvornikovs, Peggy Chiang, Timothy Coon, Sarah Hudson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:3398-3402
Extensive phase II metabolism of an advanced PKCε inhibitor resulted in sub-optimal pharmacokinetics in rat marked by elevated clearance. Synthesis of the O-glucuronide metabolite as a standard was followed by three distinct strategies to specifical
Exploring the S4 and S1 Prime Subsite Specificities in Caspase-3 with Aza-Peptide Epoxide Inhibitors
Autor:
Stjepan Jelakovic, Juliana L. Asgian, Markus G. Grütter, Rajkumar Ganesan, Zhao Zhao Li, Amy J. Campbell, James C. Powers
Publikováno v:
Biochemistry. 45:9059-9067
Caspase-3 is a prototypic executioner caspase that plays a central role in apoptosis. Aza-peptide epoxides are a novel class of irreversible inhibitors that are highly specific for clan CD cysteine proteases. The five crystal structures of caspase-3-
Autor:
Timothy Neubert, Timothy Coon, Brett B. Busch, Justin T. Ernst, Paul Krenitsky, Leonard Kaljevic, Edwin Schweiger, Andreas Termin, Jeremy J. Clemens, Dean Stamos, Juliana L. Asgian
Publikováno v:
The Journal of organic chemistry. 78(2)
Efforts to substitute the cyclopropane ring in a series of aryl cyclopropylnitriles led to the discovery of an operationally simple one-pot method for Knoevenagel condensation and subsequent Corey-Chaykovsky cyclopropanation giving diastereomerically
Autor:
Wendy Carter, Zhao Zhao Li, Jowita Mikolajczyk, Alan J. Barrett, James C. Powers, Juliana L. Asgian, Guy S. Salvesen, Karen Ellis James
Publikováno v:
Journal of Medicinal Chemistry. 45:4958-4960
Aza-peptide epoxides, a new class of irreversible protease inhibitors, are specific for the clan CD cysteine proteases. The inhibitors have second-order rate constants up to 10(5) M(-1) s(-1), with the most potent epoxides having the S,S stereochemis
Autor:
Juliana L Asgian, Markus G. Grütter, Amy J. Campbell, Özlem Doğan Ekici, Jowita Mikolajczyk, Karen Ellis James, James C Powers, Zhao Zhao Li, Guy S. Salvesen, Stjepan Jelakovic, Rajkumar Ganesan
Publikováno v:
Journal of medicinal chemistry. 49(19)
Aza-peptide Michael acceptors are a novel class of inhibitors that are potent and specific for caspases-2, -3, -6, -7, -8, -9, and -10. The second-order rate constants are in the order of 10(6) M(-1) s(-1). The aza-peptide Michael acceptor inhibitor
Autor:
Karen Ellis James, Jowita Mikolajczyk, Juliana L Asgian, Zhao Zhao Li, Guy S. Salvesen, John R Rubin, Özlem Doğan Ekici, James C Powers
Publikováno v:
Journal of medicinal chemistry. 47(6)
Aza-peptide epoxides, a novel class of irreversible protease inhibitors, are specific for the clan CD cysteine proteases. Aza-peptide epoxides with an aza-Asp residue at P1 are excellent irreversible inhibitors of caspases-1, -3, -6, and -8 with seco
Autor:
James C Powers, E. Hansell, Brian J Rukamp, Karen Ellis James, Guy S. Salvesen, Jan Potempa, Zhao Zhao Li, Jowita Mikolajczyk, James H. McKerrow, Jan Dvorák, James Travis, Juliana L Asgian, Özlem Doğan Ekici, Conor R. Caffrey, Marion G. Götz
Aza-peptide Michael acceptors are a new class of irreversible inhibitors that are highly potent and specific for clan CD cysteine proteases. The aza-Asp derivatives were specific for caspases, while aza-Asn derivatives were effective legumain inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f99ce2cbcfdba8d5a8690c4e1db94b29
https://ruj.uj.edu.pl/xmlui/handle/item/68517
https://ruj.uj.edu.pl/xmlui/handle/item/68517
Publikováno v:
Chemical reviews. 102(12)