Insights into cardiovascular effects of proline-rich oligopeptide (Bj-PRO-10c) revealed by structure-activity analyses: dissociation of antihypertensive and bradycardic effects

Autor: Carlos Henrique Xavier, Danielle Ianzer, Robson A.S. Santos, Juliana F. B. Paschoal, Antonio C.M. Camargo, Robson L. Melo, Juliana Yamaguchi, Gustavo P.B. Carretero, Shirley Schreier, José Rodolfo R. Miranda

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

We have previously reported that the proline-rich decapeptide from Bothrops jararaca (Bj-PRO-10c) causes potent and sustained antihypertensive and bradycardic effects in SHR. These activities are independent of ACE inhibition. In the present study, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::021d9675e84f12599f7a6f716ef9ab5b
https://pubmed.ncbi.nlm.nih.gov/24337901