Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Juliana D.B. Rocha"'
Autor:
Stephen E. Girardin, Tapas Mukherjee, Dana J. Philpott, Juliana D.B. Rocha, Liliane Cabral-Fernandes, Elisabeth G. Foerster
Publikováno v:
Autophagy
Macroautophagy/autophagy is a cellular catabolic process that results in lysosome-mediated recycling of organelles and protein aggregates, as well as the destruction of intracellular pathogens. Its role in the maintenance of the intestinal epithelium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a13b935ca31386175e6c0477d495e24
https://doi.org/10.1080/15548627.2021.1909406
https://doi.org/10.1080/15548627.2021.1909406
Autor:
Quinton Hake-Volling, Michaela Lunn, Claudine Beauchamp, Michael G. Schlossmacher, Julianna J. Tomlinson, Juliana D.B. Rocha, David S. Park, John D. Rioux, Bojan Shutinoski, Dana J. Philpott, Nathalie A. Lengacher, Angela Nguyen, Jasmine M. Khan, Irene E. Harmsen, John Woulfe, Kevin M. Coombs, Daniel N. El-Kodsi, Subash Sad, Jay Majithia, Paul C. Marcogliese, Earl G. Brown, Juan Li, Azadeh Alikashani, Yi Yuan Zhou, Mansoureh Hakimi, Derya R. Shimshek, Shawn Hayley
Publikováno v:
Science Translational Medicine. 11
Variants in the leucine-rich repeat kinase-2 (LRRK2) gene are associated with Parkinson's disease, leprosy, and Crohn's disease, three disorders with inflammation as an important component. Because of its high expression in granulocytes and CD68-posi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f34843f16cc16a0d7c783cd2b47594aa
https://doi.org/10.1126/scitranslmed.aas9292
https://doi.org/10.1126/scitranslmed.aas9292
BACKGROUND: Variants of the leucine-rich repeat kinase 2 (LRRK2) are associated with an increased susceptibility to Parkinson disease but also Crohn’s disease (CD). Studies using a murine colitis model have pointed to the involvement of LRRK2 in re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c657233b105fa4dec35e6382d102c0e6
https://europepmc.org/articles/PMC6507657/
https://europepmc.org/articles/PMC6507657/
Publikováno v:
Nature immunology. 16(9)
Paneth cell dysfunction has been linked to Crohn's disease. Nod2 and LRRK2, two genetic susceptibility factors for this disease, are now shown to have a role in regulating the sorting of lysozyme in Paneth cells and its secretion into the crypt space
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0683ef9237b4d991d360feb96c5a9e73
https://pubmed.ncbi.nlm.nih.gov/26237551
https://pubmed.ncbi.nlm.nih.gov/26237551