Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Juliana C. Small"'
Autor:
Juliana C. Small, Shannon M. Zintner, Malte Selch Larsen, Bo Wiinberg, Mattias Häger, Paris Margaritis, K. M. Lövgren, Maj Petersen, Mads Kjelgaard-Hansen
Publikováno v:
J Thromb Haemost
Background Prophylactic replacement therapy in hemophilia A (HA) patients does not adequately prevent bleeds and arthropathic complications. A more refined understanding of the relationship between coagulation factor VIII (FVIII) levels and bleeding
Autor:
Eric C. Peterson, Michael D. Hambuchen, William E. Fantegrossi, Laura E. Ewing, Chris Bolden, Juliana C. Small, S. Michael Owens, Shannon M. Zintner, Charles E. Hay, Paris Margaritis
Publikováno v:
J Pharmacol Exp Ther
Methamphetamine (METH) continues to be among the most addictive and abused drugs in the United States. Unfortunately, there are currently no Food and Drug Administration–approved pharmacological treatments for METH-use disorder. We have previously
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f9ec0f295f976f25a681a4752579cf3
https://europepmc.org/articles/PMC7289050/
https://europepmc.org/articles/PMC7289050/
Publikováno v:
Blood. 138:1025-1025
The development of neutralizing antibodies (inhibitors) to factor VIII (FVIII) remains the most challenging complication of protein-based replacement therapy in hemophilia A (HA). Elevated levels of the B cell survival cytokine B cell activating fact
Autor:
Chris Bolden, S. Michael Owens, Michael D. Hambuchen, Paris Margaritis, Laura E. Ewing, William E. Fantegrossi, Shannon M. Zintner, Eric C. Peterson, Charles E. Hay, Juliana C. Small
Methamphetamine (METH) continues to be amongst the most addictive and abused drugs in the US. Unfortunately, there are currently no FDA approved pharmacological treatments for METH substance abuse disorder. As an alternative approach, we have previou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ccbb65f823838cd30a8342555b0ba2b
https://doi.org/10.1101/687129
https://doi.org/10.1101/687129
Autor:
Bo Wiinberg, Shannon M. Zintner, Lynn E Dankner, Phyllis A. Gimotty, Juliana C. Small, Paris Margaritis, Mads Kjelgaard-Hansen, Oscar A. Marcos-Contreras, Giulia Pavani
Publikováno v:
Blood advances. 3(3)
A sizable proportion of hemophilia inhibitor patients fails immune tolerance induction and requires bypass agents for long-term bleed management. Recombinant human-activated coagulation Factor VII (rhFVIIa) is an on-demand bypass hemostatic agent for
Publikováno v:
Blood. 134:3629-3629
The endothelial protein C receptor (EPCR) has been demonstrated to bind activated FVII (FVIIa) through the Gla domain with equal affinity to Protein C (PC). Mouse studies suggest that EPCR is involved in the extravasation of infused human FVIIa, lead
Publikováno v:
Blood. 132:2455-2455
Activated FVII (FVIIa) has been shown to interact with EPCR resulting in long-term extravascular tissue presence in mice, well beyond its short circulating half-life. In addition, data in hemophilia patients on short term FVIIa prophylaxis indicate t
Autor:
B. Manson, Marcio O. Lasaro, E. J. Wherry, Juliana C. Small, S. Kannan, Hildegund C. J. Ertl, L. J. DiMenna, E. M. Parzych, B. P. Latimer
Publikováno v:
BioMed Research International
BioMed Research International, Vol 2013 (2013)
BioMed Research International, Vol 2013 (2013)
Influenza viruses cause severe illnesses and death, mainly in the aged population. Protection afforded by licensed vaccines through subtype-specific neutralizing antibodies is incomplete, especially when the vaccine antigens fail to closely match tho
Autor:
Giulia Pavani, Shannon M. Zintner, Katherine A. Stafford, J. H. Szeto, Paris Margaritis, Lacramioara Ivanciu, Juliana C. Small
Publikováno v:
Journal of thrombosis and haemostasis : JTH. 15(3)
Essentials The lack of factor (F) VIIa-endothelial protein C receptor (EPCR) binding in mice is unresolved. A single substitution of Leu4 to Phe in mouse FVIIa (mFVIIa) enables its interaction with EPCR. mFVIIa with a Phe4 shows EPCR binding-dependen
Autor:
Juliana C. Small, Hildegund C.J. Ertl
Publikováno v:
Current Opinion in Virology. 1:241-245
Vaccination is mankind's greatest public health success story. By now vaccines to many of the viruses that once caused fatal childhood diseases are routinely used throughout the world. Traditional methods of vaccine development through inactivation o