Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Juliana A. Martinez Fiesco"'
Autor:
Riley D. Metcalfe, Juliana A. Martinez Fiesco, Luis Bonet-Ponce, Jillian H. Kluss, Mark R. Cookson, Ping Zhang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract The human leucine-rich repeat kinases (LRRKs), LRRK1 and LRRK2 are large and unusually complex multi-domain kinases, which regulate fundamental cellular processes and have been implicated in human disease. Structures of LRRK2 have recently b
Externí odkaz:
https://doaj.org/article/7f9154c34282440f9b99657c8f3c4db7
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
RAF kinases are essential for RAS protein signalling but how RAS binding regulates dimerization and activation of RAF has remained unclear. Here, the authors report cryoEM structures that provide mechanistic insights into the RAS-mediated monomer-to-
Externí odkaz:
https://doaj.org/article/34e7836b1f4c4780b3bb919337e7db0b
Autor:
Brice A. P. Wilson, Ning Li, Juliana A. Martinez Fiesco, Masoumeh Dalilian, Dongdong Wang, Emily A. Smith, Antony Wamiru, Rohan Shah, Ekaterina I. Goncharova, John A. Beutler, Tanja Grkovic, Ping Zhang, Barry R. O’Keefe
Publikováno v:
ACS Pharmacology & Translational Science. 6:633-650
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::304996b7e53aa21cbce68dfb3e0ac41b
https://doi.org/10.1021/acsptsci.3c00010
https://doi.org/10.1021/acsptsci.3c00010
Autor:
A. Carl Whittington, Shawn M. Sternisha, Gianluigi Veglia, Malcolm M. McCray, Juliana A. Martinez Fiesco, Brian G. Miller, Carol M. Porter, Timothy M. Logan, Peter J. Steinbach, Cristina Olivieri
Publikováno v:
Biophys J
Human glucokinase (GCK) is the prototypic example of an emerging class of proteins with allosteric-like behavior that originates from intrinsic polypeptide dynamics. High-resolution NMR investigations of GCK have elucidated millisecond-timescale dyna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cc14c6349991669866e103e4d129a87
https://pubmed.ncbi.nlm.nih.gov/32023434
https://pubmed.ncbi.nlm.nih.gov/32023434
Autor:
Sanford M. Simon, Lixin Fan, Baohua Cao, Ping Zhang, Juliana A. Martinez Fiesco, Susan S. Taylor, Tsan-Wen Lu, Michael D. Tomasini
Fibrolamellar hepatocellular carcinoma (FLHCC) is driven by J-PKAcα, a kinase fusion chimera of the J-domain of DnaJB1 with PKAcα, the catalytic subunit of Protein Kinase A (PKA). Here we report the crystal structures of the chimeric fusion RIα2:J
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f7ad2b45a4d94704e7ac58b01742dd1
Autor:
Lixin Fan, Tsan-Wen Lu, Baohua Cao, Juliana A. Martinez Fiesco, Sanford M. Simon, Susan S. Taylor, Michael D. Tomasini, Ping Zhang
Publikováno v:
Structure
Fibrolamellar hepatocellular carcinoma (FLHCC) is driven by J-PKAcα, a kinase fusion chimera of the J-domain of DnaJB1 with PKAcα, the catalytic subunit of Protein Kinase A (PKA). Here we report the crystal structures of the chimeric fusion RIα(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24734e860d682cd2bf86ed23dadca86c
https://pubmed.ncbi.nlm.nih.gov/30905674
https://pubmed.ncbi.nlm.nih.gov/30905674