Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Julian Taylor Parker"'
Autor:
Yoshihiko Maehara, Masaki Mori, Julian Taylor Parker, Eiji Oki, Zhao Grace, Thomas J. Diefenbach, Ravi Salgia, Michael Voisine, Sho Nishimura, Jing Yang, Ramesh K. Ramanathan, Tomoyuki Irino, Shin Yin Lee, Ryota Nakanishi, Ben Tran, Ajit Bharti, Masanori Terashima, Hiroshi Yasui, Peter Gibbs, Matthew H. Kulke, Kevan L. Hartshorn, Al Ozonoff, Koji Ando
Publikováno v:
Clinical colorectal cancer. 20(2)
Purpose The camptothecin (CPT) analogs topotecan and irinotecan specifically target topoisomerase I (topoI) and are used to treat colorectal, gastric, and pancreatic cancer. Response rate for this class of drug varies from 10% to 30%, and there is no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::262dc02994a9c813185dd9deb11c7d6c
https://pubmed.ncbi.nlm.nih.gov/33731288
https://pubmed.ncbi.nlm.nih.gov/33731288
Autor:
Koji Ando, Yevgeniya Harrington, Ajit Bharti, Mohan Brahmandam, Ankur K. Shah, Julian Taylor-Parker, Yara Hamade Tohme, Adithi Srinivasiah, Eiji Oki
Publikováno v:
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 66(8)
Phosphorylation is the most extensively studied posttranslational modification of proteins. There are approximately 500 kinases known in the human genome. The kinase-activated pathways regulate almost every aspect of cell function and a deregulated k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e10b5f32aba5f944d19c13846659726
https://pubmed.ncbi.nlm.nih.gov/29587004
https://pubmed.ncbi.nlm.nih.gov/29587004
Autor:
Julian Taylor-Parker, Jeffrey D. Parvin, Al Ozonoff, Forest M. White, Ajit Bharti, Vibhu Sachdev, J. Keith Joung, Ravi Salgia, Koji Ando, Ankur K. Shah, Moira M. Welch, Yiheng Hu, Benjamin P. Kleinstiver, Lucia E. Rameh
Publikováno v:
Oncotarget
Impact Journals
Impact Journals
Proteasomal degradation of topoisomerase I (topoI) is one of the most remarkable cellular phenomena observed in response to camptothecin (CPT). Importantly, the rate of topoI degradation is linked to CPT resistance. Formation of the topoI-DNA-CPT cle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb2107d094ce59c25b35f5ee105be6b6
https://pubmed.ncbi.nlm.nih.gov/28415827
https://pubmed.ncbi.nlm.nih.gov/28415827
Autor:
Julian Taylor-Parker, Ajit Bharti, Deborah T. Hung, John R. Murphy, Alfred Tamayo, Louise H. Slater, Robert H. Harrison
Publikováno v:
Molecular Microbiology. 81:1390-1401
Summary Anthrax toxin is an A/B bacterial protein toxin which is composed of the enzymatically active Lethal Factor (LF) and/or Oedema Factor (EF) bound to Protective Antigen 63 (PA63) which functions as both the receptor binding and transmembrane do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be40a86857fb6e7f969d991497468779
https://doi.org/10.1111/j.1365-2958.2011.07770.x
https://doi.org/10.1111/j.1365-2958.2011.07770.x
Publikováno v:
Molecular Microbiology. 76:1010-1019
The translocation of the diphtheria toxin catalytic domain from the lumen of early endosomes into the cytosol of eukaryotic cells is an essential step in the intoxication process. We have previously shown that the in vitro translocation of the cataly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::262ab814d5a39faf43ac46a47025461d
https://doi.org/10.1111/j.1365-2958.2010.07159.x
https://doi.org/10.1111/j.1365-2958.2010.07159.x
Publikováno v:
Journal of Clinical Oncology. 34:548-548
548 Background: For gastro-intestinal cancers, irinotecan is used as first or second line, either as single agent or in combination therapy. The patient response rate is low and drug resistance mechanism is not understood. Irinotecan like other topoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4dbb86eda0033867c74873d7f8bd026
https://doi.org/10.1200/jco.2016.34.4_suppl.548
https://doi.org/10.1200/jco.2016.34.4_suppl.548
Autor:
Jeffrey D. Parvin, Julian Taylor Parker, Ajit Bharti, Vibhu Sachdev, Yiheng Hu, Yara Hamade Tohme, Ankur K. Shah, Yevnegyia Malinkovich
Publikováno v:
Cancer Research. 73:4653-4653
Abstract: The age-adjusted mortality rate for cancer is about the same in the 21st century as it was 50 years ago. In the past decade, our understanding of oncogenesis at molecular level has increased greatly. This has resulted in the development of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3112354e5965088ad95ce1195d51382d
https://doi.org/10.1158/1538-7445.am2013-4653
https://doi.org/10.1158/1538-7445.am2013-4653
Autor:
Ben Tran, Peter Gibbs, Yevgeniya Malinkovich, Umit Tapan, Julian Taylor-Parker, Ajit Bharti, Jeffrey D. Parvin, Forest M. White, Ravi Salgia, Ankur K. Shah, Yara Hamade Tohme, Vibhu Sachdew
Publikováno v:
Journal of Clinical Oncology. 33:606-606
606 Background: Topoisomerase I (topo-I) degradation by ubiquitin proteasomal pathway (UPP), in response to camptothecins (CPTs) is linked to the CPT response. But the mechanism is not understood. Methods: Improvised GST pull down experiments were pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39db27f5be79c9c63651dea90bd2387c
https://doi.org/10.1200/jco.2015.33.3_suppl.606
https://doi.org/10.1200/jco.2015.33.3_suppl.606
Autor:
Ando, Koji, Tohme, Yara Hamade, Srinivasiah, Adithi, Taylor-Parker, Julian, Harrington, Yevgeniya, Shah, Ankur K., Oki, Eiji, Brahmandam, Mohan, Bharti, Ajit K.
Publikováno v:
Journal of Histochemistry & Cytochemistry; Aug2018, Vol. 66 Issue 8, p549-561, 13p